SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 8 PHE A  30
ILE A  75
THR A  72
LEU A 102
 None
 0.90A 1hmyA-2qr4A:
undetectable		 1hmyA-2qr4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		5 / 10 LEU A 118
GLU A 158
ARG A 251
ILE A 142
LEU A  51
 None
 1.29A 1pcgA-2qr4A:
undetectable		 1pcgA-2qr4A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 7 HIS A 472
TYR A 522
TYR A 271
LEU A 261
 None
 1.00A 1qzrA-2qr4A:
undetectable		 1qzrA-2qr4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 7 HIS A 472
TYR A 522
TYR A 271
LEU A 261
 None
 0.99A 1qzrB-2qr4A:
undetectable		 1qzrB-2qr4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 7 TYR A 226
ARG A 514
TYR A 520
PHE A 175
 None
 1.17A 2ajvH-2qr4A:
undetectable
2ajvL-2qr4A:
undetectable		 2ajvH-2qr4A:
17.62
2ajvL-2qr4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 7 ALA A 418
MET A 568
TYR A 555
HIS A 398
 None
 1.37A 2pncA-2qr4A:
undetectable		 2pncA-2qr4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 6 ALA A 418
MET A 568
TYR A 555
HIS A 398
 None
 1.41A 2pncB-2qr4A:
undetectable		 2pncB-2qr4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 8 ASP A 384
LEU A 383
HIS A 449
LEU A 429
 None
 1.06A 2q0iA-2qr4A:
undetectable		 2q0iA-2qr4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		6 / 11 GLU A 191
GLY A 190
GLY A 193
ILE A 188
GLU A 189
ALA A 217
 None
 1.39A 3dxyA-2qr4A:
undetectable		 3dxyA-2qr4A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 6 LEU A 486
SER A 489
TYR A 490
LEU A 493
 None
 0.69A 3f33A-2qr4A:
2.2		 3f33A-2qr4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		5 / 10 ILE A  62
GLN A  57
PHE A  58
LEU A  59
ILE A 145
 None
 1.02A 3falC-2qr4A:
undetectable		 3falC-2qr4A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 ASN A 494
ASP A 505
ARG A 294
 None
 0.91A 3k13C-2qr4A:
undetectable		 3k13C-2qr4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		5 / 12 LEU A  51
VAL A  68
ALA A  61
ASN A  60
LEU A  41
 None
 1.08A 3r9cA-2qr4A:
undetectable		 3r9cA-2qr4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 PHE A 454
SER A 535
SER A 532
 None
 0.79A 3ufgB-2qr4A:
undetectable		 3ufgB-2qr4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		5 / 9 GLU A 208
GLY A 204
VAL A 202
GLU A 507
GLY A 221
 None
 1.19A 4fimA-2qr4A:
undetectable		 4fimA-2qr4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 6 PHE A 416
LEU A 274
VAL A 270
VAL A 573
 None
 1.16A 4g3rB-2qr4A:
undetectable		 4g3rB-2qr4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 PRO A 516
ASN A 179
HIS A 200
 None
 0.95A 4ma3H-2qr4A:
undetectable
4ma3L-2qr4A:
undetectable		 4ma3H-2qr4A:
16.41
4ma3L-2qr4A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 7 TYR A 555
GLN A 461
THR A 462
LEU A 274
 None
 1.01A 4mbsA-2qr4A:
undetectable		 4mbsA-2qr4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 GLU A 268
THR A 473
HIS A 469
 None
 0.84A 4q15A-2qr4A:
undetectable		 4q15A-2qr4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 GLU A 268
THR A 473
HIS A 469
 None
 0.87A 4q15B-2qr4A:
undetectable		 4q15B-2qr4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 GLU A 268
THR A 473
HIS A 469
 None
 0.79A 4ydqB-2qr4A:
undetectable		 4ydqB-2qr4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 ASP A  31
ARG A  98
TYR A  34
 None
 1.04A 5a7mA-2qr4A:
undetectable		 5a7mA-2qr4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 ASP A  31
ARG A  98
TYR A  34
 None
 1.05A 5a7mB-2qr4A:
undetectable		 5a7mB-2qr4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 THR A 423
ALA A 534
ASN A 427
 None
 0.54A 5ersA-2qr4A:
undetectable		 5ersA-2qr4A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		5 / 12 TYR A 555
THR A 423
THR A 424
ALA A 421
SER A 528
 None
 1.15A 5lf7V-2qr4A:
2.7
5lf7b-2qr4A:
undetectable		 5lf7V-2qr4A:
17.61
5lf7b-2qr4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		5 / 12 TYR A 555
THR A 423
THR A 424
ALA A 421
SER A 528
 None
 1.15A 5lf7H-2qr4A:
undetectable
5lf7N-2qr4A:
undetectable		 5lf7H-2qr4A:
17.61
5lf7N-2qr4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		3 / 3 HIS A 472
HIS A 244
HIS A 240
 None
 0.55A 5oexA-2qr4A:
undetectable		 5oexA-2qr4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		5 / 12 LEU A 537
MET A 334
LEU A 549
ILE A 420
LEU A 556
 None
 1.04A 5toaA-2qr4A:
undetectable		 5toaA-2qr4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 7 GLN A 124
ILE A 117
GLN A 144
TRP A 126
 None
 1.10A 5vlmC-2qr4A:
3.2		 5vlmC-2qr4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 5 LEU A 198
VAL A 196
GLU A 191
LEU A 206
 None
 1.12A 5xooB-2qr4A:
undetectable		 5xooB-2qr4A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 5 GLU A 216
PHE A 219
ASP A 505
HIS A 302
 None
 1.19A 6b58A-2qr4A:
4.2		 6b58A-2qr4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_C_ACTC609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F
(Enterococcus
faecium) 		4 / 5 GLU A 216
PHE A 219
ASP A 505
HIS A 302
 None
 1.09A 6b58C-2qr4A:
0.0		 6b58C-2qr4A:
21.76