SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 4 ALA A 281
VAL A 284
ALA A 283
HIS A 260
 None
 1.21A 1q23F-2qr6A:
undetectable		 1q23F-2qr6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 11 ALA A 197
ILE A 151
LEU A 162
ALA A 160
VAL A 193
 None
 1.07A 1rv7A-2qr6A:
undetectable
1rv7B-2qr6A:
undetectable		 1rv7A-2qr6A:
13.77
1rv7B-2qr6A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A 162
ALA A 140
ASN A  53
VAL A 143
ALA A  79
 None
 1.09A 1sa1A-2qr6A:
undetectable
1sa1B-2qr6A:
undetectable		 1sa1A-2qr6A:
22.06
1sa1B-2qr6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A 162
ALA A 140
ASN A  53
VAL A 143
ALA A  79
 None
 1.11A 1sa1C-2qr6A:
undetectable
1sa1D-2qr6A:
undetectable		 1sa1C-2qr6A:
22.06
1sa1D-2qr6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 6 ILE A 165
VAL A 164
VAL A 273
ILE A 240
ASP A 264
 None
 1.42A 1uwhB-2qr6A:
undetectable		 1uwhB-2qr6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 7 LEU A 363
GLN A 367
PHE A 366
PHE A  51
 None
 0.94A 1v55P-2qr6A:
undetectable
1v55W-2qr6A:
undetectable		 1v55P-2qr6A:
17.81
1v55W-2qr6A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 8 SER A  56
ALA A 297
PHE A  64
ALA A 293
 None
 0.80A 2bxmA-2qr6A:
undetectable		 2bxmA-2qr6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 7 LEU A 363
GLN A 367
PHE A 366
PHE A  51
 None
 0.81A 2dysC-2qr6A:
undetectable
2dysJ-2qr6A:
undetectable		 2dysC-2qr6A:
17.81
2dysJ-2qr6A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 7 LEU A 363
GLN A 367
PHE A 366
PHE A  51
 None
 0.89A 2eijP-2qr6A:
undetectable
2eijW-2qr6A:
undetectable		 2eijP-2qr6A:
17.81
2eijW-2qr6A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 7 LEU A 363
GLN A 367
PHE A 366
PHE A  51
 None
 0.73A 2zxwC-2qr6A:
undetectable
2zxwJ-2qr6A:
undetectable		 2zxwC-2qr6A:
17.81
2zxwJ-2qr6A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 6 LEU A 363
GLN A 367
PHE A 366
PHE A  51
 None
 0.75A 2zxwP-2qr6A:
undetectable
2zxwW-2qr6A:
undetectable		 2zxwP-2qr6A:
17.81
2zxwW-2qr6A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 8 LEU A 363
GLN A 367
PHE A 366
PHE A  51
 None
 0.77A 3asoC-2qr6A:
undetectable
3asoJ-2qr6A:
undetectable		 3asoC-2qr6A:
17.81
3asoJ-2qr6A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		3 / 3 ASP A 252
LEU A 251
GLN A 367
 None
 0.80A 3g4lA-2qr6A:
undetectable		 3g4lA-2qr6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 9 GLY A 220
GLY A 221
VAL A 306
ASN A 224
ILE A 218
 None
 1.31A 3owxA-2qr6A:
undetectable		 3owxA-2qr6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 5 ASP A 272
LEU A  19
ILE A 277
PHE A 366
 None
 1.24A 3s3vA-2qr6A:
undetectable		 3s3vA-2qr6A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 8 THR A 109
TRP A 303
VAL A  96
GLN A 105
 None
 0.86A 4em2A-2qr6A:
undetectable		 4em2A-2qr6A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 8 GLU A 253
ASP A 249
ARG A 248
ARG A 247
 None
 1.22A 4uhxA-2qr6A:
undetectable		 4uhxA-2qr6A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 9 ALA A  99
LEU A 112
LEU A 115
ILE A  93
 None
 0.94A 4xtaA-2qr6A:
undetectable		 4xtaA-2qr6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 10 ILE A  77
GLY A  73
LEU A  74
ALA A 140
ASP A 161
 None
 1.42A 5ajqB-2qr6A:
undetectable		 5ajqB-2qr6A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 8 ILE A 261
ALA A 197
VAL A 200
VAL A 259
 None
 0.85A 5ecnD-2qr6A:
undetectable		 5ecnD-2qr6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 6 ILE A 217
GLY A 265
MET A 236
ILE A 218
 None
 0.97A 5j4nB-2qr6A:
undetectable		 5j4nB-2qr6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE
(Corynebacterium
glutamicum) 		3 / 3 TYR A 250
ARG A 211
THR A 212
 None
 0.96A 5z84J-2qr6A:
undetectable		 5z84J-2qr6A:
9.67