SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qrw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2qrw HEMOGLOBIN-LIKE
PROTEIN HBO
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 120
HIS A 121
VAL A 124
 HEM  A 700 (-3.8A)
None
None
 0.44A 1lqtB-2qrwA:
undetectable		 1lqtB-2qrwA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2qrw HEMOGLOBIN-LIKE
PROTEIN HBO
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 120
HIS A 121
VAL A 124
 HEM  A 700 (-3.8A)
None
None
 0.43A 1lquB-2qrwA:
undetectable		 1lquB-2qrwA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2qrw HEMOGLOBIN-LIKE
PROTEIN HBO
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  69
GLU A  64
TYR A  62
 None
None
HEM  A 700 (-4.4A)
 0.81A 2zmbA-2qrwA:
undetectable		 2zmbA-2qrwA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 2qrw HEMOGLOBIN-LIKE
PROTEIN HBO
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  18
PHE A  22
TYR A  23
LEU A  52
ALA A  95
 None
 0.73A 3ozvB-2qrwA:
7.9		 3ozvB-2qrwA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2qrw HEMOGLOBIN-LIKE
PROTEIN HBO
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  96
HIS A 108
VAL A   9
 None
 0.67A 5jmnC-2qrwA:
2.8		 5jmnC-2qrwA:
8.04