SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qs9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		5 / 12 ALA A  92
LEU A 181
LEU A 182
ILE A 175
LEU A 153
 None
 1.18A 1errB-2qs9A:
undetectable		 1errB-2qs9A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		4 / 8 SER A  97
GLN A 167
PHE A 166
ASP A 138
 None
 1.35A 1p6kA-2qs9A:
undetectable		 1p6kA-2qs9A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		4 / 8 SER A  97
GLN A 167
PHE A 166
ASP A 138
 None
 1.34A 1zzuA-2qs9A:
undetectable		 1zzuA-2qs9A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		3 / 3 GLY A  16
GLY A  12
GLY A  14
 None
 0.33A 3bogC-2qs9A:
undetectable		 3bogC-2qs9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		5 / 12 SER A 111
TYR A  99
ALA A  50
GLY A  14
GLY A  12
 None
 1.07A 3f8wA-2qs9A:
undetectable		 3f8wA-2qs9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		5 / 12 SER A 111
TYR A  99
ALA A  50
GLY A  14
GLY A  12
 None
 1.08A 3f8wC-2qs9A:
undetectable		 3f8wC-2qs9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		4 / 8 SER A  53
ILE A  54
TRP A  55
GLU A  52
 None
 1.15A 4cx7A-2qs9A:
undetectable
4cx7B-2qs9A:
undetectable		 4cx7A-2qs9A:
19.54
4cx7B-2qs9A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		4 / 8 SER A  53
ILE A  54
TRP A  55
GLU A  52
 None
 1.19A 4cx7C-2qs9A:
undetectable
4cx7D-2qs9A:
undetectable		 4cx7C-2qs9A:
19.54
4cx7D-2qs9A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		4 / 6 ALA A  98
GLN A 146
LEU A  95
LEU A 157
 None
 1.24A 4xp3A-2qs9A:
undetectable		 4xp3A-2qs9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		5 / 12 VAL A  90
ASP A  66
LEU A 174
ALA A  92
PRO A   4
 None
 1.14A 5hnzB-2qs9A:
3.3		 5hnzB-2qs9A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		5 / 10 LEU A 174
ASP A 138
ILE A  72
SER A  75
GLY A  73
 None
 1.25A 6dlzA-2qs9A:
2.5
6dlzD-2qs9A:
5.0		 6dlzA-2qs9A:
13.33
6dlzD-2qs9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		5 / 10 ILE A  72
SER A  75
GLY A  73
LEU A 174
ASP A 138
 None
 1.26A 6dlzB-2qs9A:
5.0
6dlzC-2qs9A:
2.9		 6dlzB-2qs9A:
13.33
6dlzC-2qs9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		5 / 10 LEU A 174
ASP A 138
ILE A  72
SER A  75
GLY A  73
 None
 1.26A 6dm1A-2qs9A:
2.5
6dm1D-2qs9A:
5.0		 6dm1A-2qs9A:
13.33
6dm1D-2qs9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens) 		5 / 10 ILE A  72
SER A  75
GLY A  73
LEU A 174
ASP A 138
 None
 1.27A 6dm1B-2qs9A:
5.0
6dm1C-2qs9A:
3.1		 6dm1B-2qs9A:
13.33
6dm1C-2qs9A:
13.33