SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qsf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 594
THR A 595
GLU A 575
LEU A 609
 None
 0.99A 1s8fB-2qsfA:
undetectable		 1s8fB-2qsfA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 271
ILE A 162
VAL A 255
LEU A 246
GLN A 267
 None
 1.33A 1udtA-2qsfA:
undetectable		 1udtA-2qsfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 280
VAL A 319
LEU A 183
HIS A 184
 None
 0.91A 2it4A-2qsfA:
undetectable		 2it4A-2qsfA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 402
VAL A 405
PHE A 315
LEU A 225
TYR A 366
 None
 1.46A 3apxA-2qsfA:
undetectable		 3apxA-2qsfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 194
PHE A 323
GLN A 186
PRO A 185
 None
 1.50A 3gclA-2qsfA:
undetectable		 3gclA-2qsfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 280
ARG A 368
LYS A 369
 None
 0.90A 3kp3B-2qsfA:
1.3		 3kp3B-2qsfA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 202
GLU A 208
LEU A 200
LEU A 199
ILE A 328
 None
 1.35A 3kvrB-2qsfA:
undetectable		 3kvrB-2qsfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 584
ALA A 582
VAL A 574
PRO A 568
ILE A 551
 None
 1.37A 4j4vD-2qsfA:
0.5
4j4vE-2qsfA:
undetectable		 4j4vD-2qsfA:
18.69
4j4vE-2qsfA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		5 / 11 PRO A 332
ASP A 331
SER A 285
ASP A 263
ILE A 314
 None
 1.47A 4ktvC-2qsfA:
undetectable
4ktvD-2qsfA:
undetectable		 4ktvC-2qsfA:
22.31
4ktvD-2qsfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 570
SER A 548
ALA A 615
VAL A 614
 None
 1.36A 4x1kC-2qsfA:
undetectable		 4x1kC-2qsfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 344
VAL A 341
TYR A 424
GLN A 381
 None
 1.23A 5kkzK-2qsfA:
undetectable
5kkzQ-2qsfA:
0.0		 5kkzK-2qsfA:
22.18
5kkzQ-2qsfA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 144
LYS A 141
PHE A 291
 None
 1.12A 5klaA-2qsfA:
undetectable		 5klaA-2qsfA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 268
VAL A 333
SER A 168
VAL A 255
LEU A 252
 None
 1.27A 5ubbA-2qsfA:
undetectable		 5ubbA-2qsfA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 281
PHE A 425
ARG A 378
 None
 0.83A 5y9yA-2qsfA:
undetectable		 5y9yA-2qsfA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 319
ALA A 280
LEU A 203
LEU A 182
LEU A 199
 None
 0.97A 6f6nA-2qsfA:
undetectable
6f6nB-2qsfA:
undetectable		 6f6nA-2qsfA:
9.64
6f6nB-2qsfA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 225
ASP A 263
ASP A 261
GLN A 267
 None
 1.39A 6g31D-2qsfA:
undetectable		 6g31D-2qsfA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2qsf DNA REPAIR PROTEIN
RAD4
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 280
VAL A 319
ARG A 281
ASP A 418
 None
 0.91A 6hu9a-2qsfA:
undetectable
6hu9e-2qsfA:
undetectable		 6hu9a-2qsfA:
20.79
6hu9e-2qsfA:
13.03