SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qtk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 123
ASP A 289
GLY A 293
ASN A 292
GLN A 379
 None
 1.33A 2ycjA-2qtkA:
undetectable		 2ycjA-2qtkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 125
ASP A 123
SER A 282
 None
 0.56A 3brfA-2qtkA:
undetectable		 3brfA-2qtkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 297
ASP A 233
GLN A 208
 None
 0.84A 3eeyE-2qtkA:
undetectable		 3eeyE-2qtkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 130
LEU A 166
ASN A 180
LEU A 120
LEU A 202
 None
 1.42A 3fsuA-2qtkA:
undetectable		 3fsuA-2qtkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  16
GLU A 347
ASP A 308
 None
 0.94A 3g2oA-2qtkA:
undetectable		 3g2oA-2qtkA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 378
SER A 368
HIS A 366
ASP A  23
 None
None
C8E  A 393 ( 4.4A)
None
 1.09A 3sg9B-2qtkA:
undetectable		 3sg9B-2qtkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 8 GLY A  96
ALA A  60
ASP A  59
ILE A  42
THR A  11
 None
 1.31A 3so9A-2qtkA:
undetectable		 3so9A-2qtkA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 4 ASP A 245
ASP A 272
GLY A 274
THR A 332
 None
 1.11A 3tl9B-2qtkA:
undetectable		 3tl9B-2qtkA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 311
VAL A 323
TYR A 307
GLY A 321
 None
C8E  A 393 ( 4.4A)
C8E  A 394 ( 3.6A)
C8E  A 393 (-3.7A)
 0.76A 4m48A-2qtkA:
undetectable		 4m48A-2qtkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 8 TRP A 275
SER A 170
TYR A 206
ILE A 244
 None
 1.29A 4ms4A-2qtkA:
undetectable		 4ms4A-2qtkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 126
ASP A 123
ARG A 381
 None
 0.72A 4mx0A-2qtkA:
undetectable		 4mx0A-2qtkA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 145
GLU A 141
VAL A 137
ALA A 149
 None
None
C8E  A 395 ( 4.7A)
C8E  A 395 ( 4.4A)
 0.88A 4nkxA-2qtkA:
undetectable		 4nkxA-2qtkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 161
GLY A  65
GLY A  93
GLY A  62
LEU A 127
 None
None
None
C8E  A 396 ( 4.6A)
None
 1.13A 5c0oE-2qtkA:
undetectable		 5c0oE-2qtkA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 381
ARG A 324
ARG A 363
 None
 0.80A 6bplA-2qtkA:
undetectable
6bplB-2qtkA:
undetectable		 6bplA-2qtkA:
12.26
6bplB-2qtkA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 293
ASN A 294
ASP A 289
SER A 282
 None
 1.02A 6dwdA-2qtkA:
undetectable
6dwdC-2qtkA:
undetectable		 6dwdA-2qtkA:
19.96
6dwdC-2qtkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2qtk PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 289
ARG A 324
GLU A 343
GLU A 347
 None
 1.45A 6mn5D-2qtkA:
undetectable		 6mn5D-2qtkA:
12.02