SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qtn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 11 HIS A  15
GLY A  17
HIS A  18
GLY A 106
ILE A 105
 None
 1.15A 1pg2A-2qtnA:
3.8		 1pg2A-2qtnA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		4 / 8 GLY A   5
VAL A  34
GLU A  33
ILE A 104
 None
 0.92A 1pk7B-2qtnA:
undetectable		 1pk7B-2qtnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ARG A  56
PHE A  36
GLY A   9
ILE A 104
PHE A  70
 None
None
GOL  A 191 ( 4.0A)
None
None
 1.33A 2zznB-2qtnA:
undetectable		 2zznB-2qtnA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		4 / 6 VAL A 147
VAL A 129
ILE A 104
LEU A  20
 None
 0.93A 4l1wB-2qtnA:
undetectable		 4l1wB-2qtnA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		4 / 4 ALA A  22
HIS A  69
PHE A  70
LEU A  31
 None
 1.30A 4lufA-2qtnA:
0.0		 4lufA-2qtnA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		4 / 4 ALA A  22
HIS A  69
PHE A  70
LEU A  31
 None
 1.32A 4luhA-2qtnA:
0.0		 4luhA-2qtnA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 7 ILE A   6
CYH A  73
LEU A  37
GLY A   9
GLY A   8
 None
None
None
GOL  A 191 ( 4.0A)
None
 1.46A 5a06A-2qtnA:
undetectable		 5a06A-2qtnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 7 ILE A   6
CYH A  73
LEU A  37
GLY A   9
GLY A   8
 None
None
None
GOL  A 191 ( 4.0A)
None
 1.47A 5a06C-2qtnA:
3.1		 5a06C-2qtnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 7 ILE A   6
CYH A  73
LEU A  37
GLY A   9
GLY A   8
 None
None
None
GOL  A 191 ( 4.0A)
None
 1.45A 5a06E-2qtnA:
undetectable		 5a06E-2qtnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 7 ILE A   6
CYH A  73
LEU A  37
GLY A   9
GLY A   8
 None
None
None
GOL  A 191 ( 4.0A)
None
 1.44A 5a06F-2qtnA:
3.1		 5a06F-2qtnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A  19
ALA A  63
LEU A  60
ILE A   7
ALA A  22
 None
 1.31A 5nm5B-2qtnA:
undetectable		 5nm5B-2qtnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		3 / 3 GLY A   5
LEU A  31
HIS A 102
 None
 0.71A 5u63A-2qtnA:
undetectable		 5u63A-2qtnA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		3 / 3 GLY A   5
LEU A  31
HIS A 102
 None
 0.68A 5u63B-2qtnA:
undetectable		 5u63B-2qtnA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A  29
VAL A 126
MET A  89
LEU A  92
THR A  93
 None
 1.12A 6b52A-2qtnA:
undetectable		 6b52A-2qtnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		4 / 5 GLY A   8
HIS A  18
SER A 155
SER A 156
 None
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.75A 6jmjA-2qtnA:
14.7		 6jmjA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		4 / 5 GLY A   9
THR A  10
HIS A  18
SER A 156
 GOL  A 191 ( 4.0A)
GOL  A 191 (-3.2A)
None
GOL  A 191 (-4.1A)
 0.86A 6jmjA-2qtnA:
14.7		 6jmjA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		4 / 5 THR A  10
HIS A  18
SER A 155
SER A 156
 GOL  A 191 (-3.2A)
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.77A 6jmjA-2qtnA:
14.7		 6jmjA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 7 GLY A   8
PHE A  11
HIS A  18
SER A 155
SER A 156
 None
None
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.94A 6jnhA-2qtnA:
14.7		 6jnhA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		6 / 7 GLY A   9
THR A  10
PHE A  11
HIS A  18
SER A 155
SER A 156
 GOL  A 191 ( 4.0A)
GOL  A 191 (-3.2A)
None
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.83A 6jnhA-2qtnA:
14.7		 6jnhA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		4 / 6 GLY A   8
HIS A  18
SER A 155
SER A 156
 None
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.80A 6jogA-2qtnA:
14.7		 6jogA-2qtnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE
(Bacillus
anthracis) 		5 / 6 GLY A   9
THR A  10
HIS A  18
SER A 155
SER A 156
 GOL  A 191 ( 4.0A)
GOL  A 191 (-3.2A)
None
GOL  A 191 (-3.8A)
GOL  A 191 (-4.1A)
 0.87A 6jogA-2qtnA:
14.7		 6jogA-2qtnA:
26.32