SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		5 / 11 LEU A 115
GLU A 239
ALA A 162
GLY A 163
TYR A 159
 None
 1.30A 1l5rA-2qtsA:
undetectable		 1l5rA-2qtsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		4 / 5 TYR A 335
PHE A 153
TYR A 341
PRO A 338
 None
 1.33A 1mclA-2qtsA:
0.0
1mclB-2qtsA:
0.9
1mclP-2qtsA:
undetectable		 1mclA-2qtsA:
17.83
1mclB-2qtsA:
17.83
1mclP-2qtsA:
0.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		5 / 12 ILE A 250
VAL A  91
ASN A 199
CYH A 276
LEU A  86
 None
 1.12A 1wsvB-2qtsA:
undetectable		 1wsvB-2qtsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		5 / 11 ILE A 409
VAL A 248
PHE A  93
VAL A  91
ILE A 246
 None
 1.04A 3rf4A-2qtsA:
undetectable
3rf4C-2qtsA:
undetectable		 3rf4A-2qtsA:
17.19
3rf4C-2qtsA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		5 / 11 ILE A 246
ILE A 409
VAL A 248
PHE A  93
VAL A  91
 None
 1.03A 3rf4B-2qtsA:
undetectable
3rf4C-2qtsA:
undetectable		 3rf4B-2qtsA:
17.19
3rf4C-2qtsA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		3 / 3 GLU A 278
TYR A 371
SER A 252
 None
None
NAG  A   1 ( 4.0A)
 0.91A 4at0A-2qtsA:
undetectable		 4at0A-2qtsA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		4 / 5 GLY A 432
ASP A 433
GLU A 426
VAL A  75
 None
 1.16A 4nkvD-2qtsA:
undetectable		 4nkvD-2qtsA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		4 / 6 GLU A 236
ASP A 238
ASP A 350
GLU A 354
 None
 0.32A 4ntxA-2qtsA:
11.4
4ntxC-2qtsA:
2.2		 4ntxA-2qtsA:
100.00
4ntxC-2qtsA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		5 / 12 ASP A 108
VAL A 104
PHE A 189
PHE A  99
GLY A 163
 None
 1.43A 4pevA-2qtsA:
undetectable		 4pevA-2qtsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		5 / 12 ASP A 108
VAL A 104
PHE A 189
PHE A  99
GLY A 163
 None
 1.39A 4pevB-2qtsA:
undetectable		 4pevB-2qtsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		4 / 4 ASN A 199
SER A 252
ALA A  90
VAL A  91
 None
NAG  A   1 ( 4.0A)
None
None
 1.25A 4x1kC-2qtsA:
undetectable		 4x1kC-2qtsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA612_0
(SERUM ALBUMIN)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		4 / 4 SER A 252
HIS A 251
GLU A 255
PRO A 256
 NAG  A   1 ( 4.0A)
None
None
None
 1.46A 5dbyA-2qtsA:
2.9		 5dbyA-2qtsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		4 / 7 VAL A 266
VAL A 248
PHE A  93
ILE A 221
 None
 0.85A 5yf9B-2qtsA:
undetectable		 5yf9B-2qtsA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2qts ACID-SENSING ION
CHANNEL
(Gallus
gallus) 		4 / 6 LEU A 219
LEU A 223
THR A  92
ARG A 100
 None
 1.00A 6ew0G-2qtsA:
undetectable		 6ew0G-2qtsA:
9.36