SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qtv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2qtv SMALL COPII COAT
GTPASE SAR1
(Saccharomyces
cerevisiae) 		4 / 5 ARG B 105
ALA B 109
ASP B  32
GLY B  30
 None
 1.19A 1e7bA-2qtvB:
undetectable		 1e7bA-2qtvB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2qtv SMALL COPII COAT
GTPASE SAR1
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 151
VAL B  98
GLY B 131
LEU B 113
 None
 0.96A 1jlbA-2qtvB:
undetectable		 1jlbA-2qtvB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2qtv SMALL COPII COAT
GTPASE SAR1
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 151
VAL B  98
GLY B 131
LEU B 113
 None
 1.01A 1s1xA-2qtvB:
undetectable		 1s1xA-2qtvB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2qtv SMALL COPII COAT
GTPASE SAR1
PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASN D 915
ASN D 919
ARG B  82
 None
 0.94A 2rlcA-2qtvD:
undetectable		 2rlcA-2qtvD:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2qtv SMALL COPII COAT
GTPASE SAR1
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 122
VAL B 128
ARG B 164
 None
 0.89A 3b0wB-2qtvB:
undetectable		 3b0wB-2qtvB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2qtv SMALL COPII COAT
GTPASE SAR1
(Saccharomyces
cerevisiae) 		4 / 5 ASP B  73
LEU B  74
ILE B  94
PHE B  96
 MG  B 210 ( 4.2A)
None
None
None
 1.15A 3s3vA-2qtvB:
undetectable		 3s3vA-2qtvB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2qtv SMALL COPII COAT
GTPASE SAR1
(Saccharomyces
cerevisiae) 		4 / 5 ASP B  99
ASN B 132
ILE B 134
VAL B 174
 None
GNP  B 200 (-3.6A)
None
GNP  B 200 (-3.9A)
 1.39A 4hytA-2qtvB:
2.8		 4hytA-2qtvB:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2qtv SMALL COPII COAT
GTPASE SAR1
(Saccharomyces
cerevisiae) 		3 / 3 LEU B  83
ASP B  86
TYR B  87
 None
 0.65A 4qc6B-2qtvB:
undetectable		 4qc6B-2qtvB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 2qtv SMALL COPII COAT
GTPASE SAR1
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 114
LEU B 151
GLY B 150
 None
 0.57A 4xmfA-2qtvB:
undetectable		 4xmfA-2qtvB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 2qtv SMALL COPII COAT
GTPASE SAR1
PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU B  74
GLY B  75
SER D 908
TYR B  87
LEU B  27
 None
GNP  B 200 ( 4.0A)
None
None
None
 1.39A 5czyA-2qtvB:
undetectable		 5czyA-2qtvB:
16.63