SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 12 LEU A  15
GLY A  13
MET A 316
ALA A 337
LEU A 336
 None
 0.94A 1gs4A-2qtyA:
undetectable		 1gs4A-2qtyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 12 GLY A  17
LEU A 289
LEU A 285
PRO A 320
VAL A 319
 None
 1.25A 1gseA-2qtyA:
1.4		 1gseA-2qtyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 7 LEU A  74
LEU A  69
TYR A 148
LEU A 146
 None
 0.91A 1kt3A-2qtyA:
undetectable		 1kt3A-2qtyA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 8 PHE A 195
ILE A 265
LEU A 237
GLY A 234
 None
 0.54A 1rtsA-2qtyA:
undetectable		 1rtsA-2qtyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 12 LEU A 285
LEU A 289
ALA A 264
ILE A 309
ALA A 308
 None
 0.90A 2bxcA-2qtyA:
undetectable		 2bxcA-2qtyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 12 THR A 288
GLY A 307
LEU A  11
GLY A 143
ALA A 312
 None
 0.97A 2fk8A-2qtyA:
undetectable		 2fk8A-2qtyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 12 LEU A  15
LEU A  16
GLY A  13
ALA A 337
LEU A 336
 None
 1.18A 2oz7A-2qtyA:
undetectable		 2oz7A-2qtyA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		3 / 3 SER A 168
TYR A 172
HIS A 166
 None
 0.58A 2r2vD-2qtyA:
undetectable		 2r2vD-2qtyA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		3 / 3 GLY A 171
TYR A 172
SER A 168
 None
 0.72A 2xatA-2qtyA:
undetectable		 2xatA-2qtyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 6 ALA A 158
ALA A 162
THR A 165
PHE A  88
 None
 1.09A 2xfhA-2qtyA:
undetectable		 2xfhA-2qtyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 12 ASP A 298
GLU A  25
THR A 301
ASP A  61
GLY A 103
 MG  A 349 (-2.6A)
MG  A 349 (-3.0A)
MG  A 349 (-3.4A)
MG  A 348 (-2.7A)
None
 1.20A 3ce6D-2qtyA:
undetectable		 3ce6D-2qtyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 12 VAL A 261
ALA A 257
VAL A 233
VAL A 141
ILE A 176
 None
 1.12A 3dl9A-2qtyA:
undetectable		 3dl9A-2qtyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 10 LEU A  36
ILE A 278
ARG A 287
PRO A 320
SER A 322
 None
 1.00A 3hcpB-2qtyA:
undetectable		 3hcpB-2qtyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 12 GLY A  13
GLY A   9
ALA A 306
ALA A 303
LEU A 289
 None
 1.04A 3p2kC-2qtyA:
undetectable		 3p2kC-2qtyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 4 LYS A   1
GLN A 187
ILE A 309
LEU A 285
 None
 1.10A 3qt0A-2qtyA:
0.0		 3qt0A-2qtyA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 5 GLY A 143
ARG A 140
GLN A 155
MET A 203
 None
 1.13A 3qx3A-2qtyA:
undetectable		 3qx3A-2qtyA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 9 TYR A 172
ASN A 173
ILE A 176
ARG A 159
GLU A 207
 None
 0.95A 3rukC-2qtyA:
0.0		 3rukC-2qtyA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 6 HIS A 166
GLY A 137
TYR A 133
ALA A 175
 None
 0.88A 4ae1A-2qtyA:
undetectable		 4ae1A-2qtyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 7 LEU A  36
ARG A 287
PRO A 320
SER A 322
 None
 0.76A 4klrA-2qtyA:
undetectable		 4klrA-2qtyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 8 LEU A  36
ARG A 287
PRO A 320
SER A 322
 None
 0.83A 4klrB-2qtyA:
undetectable		 4klrB-2qtyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 5 LEU A  36
ARG A 287
PRO A 320
SER A 322
 None
 0.93A 4kmmB-2qtyA:
undetectable		 4kmmB-2qtyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 6 ASP A 300
ASP A 298
ALA A 257
ASP A  62
 MG  A 349 ( 2.4A)
MG  A 349 (-2.6A)
None
MG  A 348 (-2.9A)
 1.13A 4mdaA-2qtyA:
undetectable		 4mdaA-2qtyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 6 ASP A 300
ASP A 298
ALA A 257
ASP A  62
 MG  A 349 ( 2.4A)
MG  A 349 (-2.6A)
None
MG  A 348 (-2.9A)
 1.16A 4mdbA-2qtyA:
undetectable		 4mdbA-2qtyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		3 / 3 ILE A   4
ASP A 334
ARG A 342
 None
 0.84A 4pstA-2qtyA:
undetectable		 4pstA-2qtyA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 6 PHE A 127
GLY A 134
TYR A 133
ALA A 256
 None
 1.15A 4yshB-2qtyA:
undetectable		 4yshB-2qtyA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 7 LEU A 289
THR A 288
ILE A 309
LEU A 269
 None
 1.05A 5fxtA-2qtyA:
undetectable		 5fxtA-2qtyA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 7 PHE A 195
ILE A 265
LEU A 237
GLY A 234
 None
 0.57A 5h3aB-2qtyA:
undetectable		 5h3aB-2qtyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 12 ASP A 298
LEU A 289
ALA A 303
ASN A 135
GLY A 136
 MG  A 349 (-2.6A)
None
None
None
None
 1.02A 5kb5A-2qtyA:
undetectable		 5kb5A-2qtyA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 6 ASP A 209
ARG A 159
ASN A 173
GLN A 163
 None
 1.06A 5l6eA-2qtyA:
undetectable		 5l6eA-2qtyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 6 LEU A  32
VAL A  30
LEU A 251
GLU A 246
 None
 0.98A 5tudD-2qtyA:
undetectable		 5tudD-2qtyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 8 SER A 132
HIS A 166
MET A  65
THR A 301
 None
None
None
MG  A 349 (-3.4A)
 1.48A 5u6nA-2qtyA:
undetectable		 5u6nA-2qtyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 4 LEU A  69
LEU A  73
SER A 145
ALA A 147
 None
 0.99A 5uunA-2qtyA:
undetectable		 5uunA-2qtyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 7 PHE A 195
ILE A 265
LEU A 237
GLY A 234
 None
 0.51A 5x5qC-2qtyA:
undetectable		 5x5qC-2qtyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 8 PHE A 195
ILE A 265
LEU A 237
GLY A 234
 None
 0.54A 5x5qD-2qtyA:
undetectable		 5x5qD-2qtyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 6 PHE A 195
ILE A 265
LEU A 237
GLY A 234
 None
 0.55A 5x5qE-2qtyA:
undetectable		 5x5qE-2qtyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 8 PHE A 195
ILE A 265
LEU A 237
GLY A 234
 None
 0.54A 5x5qF-2qtyA:
undetectable		 5x5qF-2qtyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		4 / 5 MET A 221
TYR A 133
GLY A 171
GLY A 174
 None
 1.13A 5x7pA-2qtyA:
undetectable		 5x7pA-2qtyA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3
(Mus
musculus) 		5 / 8 GLY A 171
VAL A 141
GLY A 254
SER A 260
ALA A 264
 None
 1.38A 6hu9H-2qtyA:
undetectable
6hu9e-2qtyA:
undetectable		 6hu9H-2qtyA:
12.72
6hu9e-2qtyA:
16.81