SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qtz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 7 SER A 226
PHE A 416
VAL A 232
ALA A 411
 None
 1.03A 1fo4B-2qtzA:
undetectable		 1fo4B-2qtzA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		3 / 3 GLN A 634
ILE A 538
HIS A 646
 None
 0.75A 1k74A-2qtzA:
undetectable		 1k74A-2qtzA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A 553
LEU A 556
HIS A 558
GLU A 592
ILE A 601
 None
 1.09A 1kyvC-2qtzA:
undetectable
1kyvD-2qtzA:
undetectable		 1kyvC-2qtzA:
15.57
1kyvD-2qtzA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A 553
LEU A 556
HIS A 558
GLU A 592
ILE A 601
 None
 1.08A 1kyvD-2qtzA:
undetectable
1kyvE-2qtzA:
undetectable		 1kyvD-2qtzA:
15.57
1kyvE-2qtzA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 7 ASP A 586
PHE A 578
SER A 610
ARG A 611
 None
None
NAP  A 701 (-2.7A)
NAP  A 701 (-3.9A)
 1.19A 1rqpB-2qtzA:
3.6		 1rqpB-2qtzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 8 ASP A 586
PHE A 578
SER A 610
ARG A 611
 None
None
NAP  A 701 (-2.7A)
NAP  A 701 (-3.9A)
 1.20A 1rqpC-2qtzA:
3.8		 1rqpC-2qtzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 8 VAL A 417
ASP A 419
PRO A 380
LEU A 385
 None
 1.02A 1z2bB-2qtzA:
4.5		 1z2bB-2qtzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 11 LEU A 328
LEU A 333
ILE A 369
PRO A 361
LEU A 424
 None
 1.19A 2ft9A-2qtzA:
undetectable		 2ft9A-2qtzA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 8 ASP A 586
PHE A 578
SER A 610
ARG A 611
 None
None
NAP  A 701 (-2.7A)
NAP  A 701 (-3.9A)
 1.15A 2v7uA-2qtzA:
3.8		 2v7uA-2qtzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 7 ASP A 586
PHE A 578
SER A 610
ARG A 611
 None
None
NAP  A 701 (-2.7A)
NAP  A 701 (-3.9A)
 1.16A 2v7uB-2qtzA:
2.0		 2v7uB-2qtzA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 548
GLY A 651
ASP A 695
ASP A 586
LEU A 588
 None
None
FAD  A 700 ( 4.5A)
None
None
 1.17A 2zw9B-2qtzA:
4.2		 2zw9B-2qtzA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 12 LEU A 250
LEU A 343
PRO A 380
PRO A 437
PRO A 436
 None
 1.24A 3dcjA-2qtzA:
4.0
3dcjB-2qtzA:
3.7		 3dcjA-2qtzA:
17.48
3dcjB-2qtzA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 12 LEU A 284
LEU A 593
THR A 547
ILE A 549
ALA A 550
 None
None
FAD  A 700 ( 4.6A)
None
FAD  A 700 ( 4.7A)
 0.72A 3mdvB-2qtzA:
undetectable		 3mdvB-2qtzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 546
GLY A 579
VAL A 543
ALA A 550
SER A 610
 NAP  A 701 ( 3.9A)
None
None
FAD  A 700 ( 4.7A)
NAP  A 701 (-2.7A)
 1.13A 3mteA-2qtzA:
4.2		 3mteA-2qtzA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 546
GLY A 579
VAL A 543
ALA A 550
SER A 610
 NAP  A 701 ( 3.9A)
None
None
FAD  A 700 ( 4.7A)
NAP  A 701 (-2.7A)
 1.06A 3p2kD-2qtzA:
4.3		 3p2kD-2qtzA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 8 ALA A 657
VAL A 660
LEU A 664
LEU A 693
 None
 0.75A 3roxA-2qtzA:
4.2		 3roxA-2qtzA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 5 VAL A 469
LEU A 295
LEU A 284
ILE A 553
 None
 0.91A 4a9jA-2qtzA:
undetectable		 4a9jA-2qtzA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		3 / 3 ARG A 611
HIS A 582
SER A 610
 NAP  A 701 (-3.9A)
None
NAP  A 701 (-2.7A)
 0.68A 4mjwA-2qtzA:
4.4
4mjwB-2qtzA:
undetectable		 4mjwA-2qtzA:
21.74
4mjwB-2qtzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		3 / 3 SER A 610
ARG A 611
HIS A 582
 NAP  A 701 (-2.7A)
NAP  A 701 (-3.9A)
None
 0.64A 4mjwA-2qtzA:
4.4
4mjwB-2qtzA:
undetectable		 4mjwA-2qtzA:
21.74
4mjwB-2qtzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		3 / 3 ARG A 451
GLN A 449
GLU A 375
 FAD  A 700 (-3.9A)
None
None
 0.81A 4tvtA-2qtzA:
undetectable		 4tvtA-2qtzA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 579
TYR A 624
LEU A 576
GLY A 548
ILE A 549
 None
NAP  A 701 (-3.7A)
None
None
None
 0.97A 5d4uC-2qtzA:
3.5		 5d4uC-2qtzA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 579
TYR A 624
LEU A 576
GLY A 548
ILE A 549
 None
NAP  A 701 (-3.7A)
None
None
None
 0.95A 5d4uD-2qtzA:
2.7		 5d4uD-2qtzA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 6 LEU A 328
LEU A 425
PHE A 370
LEU A 441
 None
 0.83A 5gs4A-2qtzA:
undetectable		 5gs4A-2qtzA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 6 LEU A 328
LEU A 428
LEU A 425
PHE A 370
LEU A 445
 None
 1.35A 5gs4A-2qtzA:
undetectable		 5gs4A-2qtzA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 5 LEU A 328
LEU A 428
PHE A 370
LEU A 441
 None
 1.05A 5gtrA-2qtzA:
undetectable		 5gtrA-2qtzA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		3 / 3 ASP A 304
ASN A 302
PHE A 523
 None
 0.89A 5jglB-2qtzA:
undetectable		 5jglB-2qtzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		3 / 3 LYS A 606
HIS A 604
HIS A 632
 None
 1.10A 5oexB-2qtzA:
undetectable		 5oexB-2qtzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		3 / 3 LYS A 606
HIS A 604
HIS A 632
 None
 1.09A 5oexC-2qtzA:
undetectable		 5oexC-2qtzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		6 / 9 SER A 454
THR A 547
GLY A 548
ALA A 550
CYH A 650
GLY A 651
 FAD  A 700 (-3.2A)
FAD  A 700 ( 4.6A)
None
FAD  A 700 ( 4.7A)
None
None
 0.61A 5vw4A-2qtzA:
28.3		 5vw4A-2qtzA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 8 SER A 454
GLY A 548
CYH A 650
GLY A 651
 FAD  A 700 (-3.2A)
None
None
None
 0.56A 5vw5A-2qtzA:
28.2		 5vw5A-2qtzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 8 THR A 547
GLY A 548
CYH A 650
GLY A 651
 FAD  A 700 ( 4.6A)
None
None
None
 0.29A 5vw5A-2qtzA:
28.2		 5vw5A-2qtzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		6 / 8 SER A 454
THR A 547
GLY A 548
ALA A 550
CYH A 650
GLY A 651
 FAD  A 700 (-3.2A)
FAD  A 700 ( 4.6A)
None
FAD  A 700 ( 4.7A)
None
None
 0.63A 5vw9A-2qtzA:
28.4		 5vw9A-2qtzA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		4 / 6 LEU A 254
LYS A 341
LEU A 343
LEU A 442
 CSO  A 340 ( 4.8A)
CSO  A 340 ( 3.2A)
None
None
 1.18A 5yvnA-2qtzA:
undetectable		 5yvnA-2qtzA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens) 		5 / 9 LEU A 466
ILE A 522
PHE A 274
VAL A 276
ILE A 300
 None
 1.24A 6ef6A-2qtzA:
undetectable		 6ef6A-2qtzA:
22.22