SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1
(Plasmodium
falciparum) 		5 / 8 PHE A 133
ILE A 171
PHE A 181
PHE A 149
VAL A 175
 None
 1.44A 1fslA-2qu8A:
undetectable		 1fslA-2qu8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1
(Plasmodium
falciparum) 		4 / 7 PHE A 184
SER A 183
ILE A 130
ILE A 116
 None
 0.95A 1sbrB-2qu8A:
undetectable		 1sbrB-2qu8A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1
(Plasmodium
falciparum) 		5 / 9 ILE A 136
GLY A  36
ILE A 115
VAL A 111
ILE A 145
 None
 1.09A 3d1yB-2qu8A:
undetectable		 3d1yB-2qu8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1
(Plasmodium
falciparum) 		5 / 12 ILE A 136
GLY A  36
ILE A 115
VAL A 111
ILE A 145
 None
 1.01A 3tkgB-2qu8A:
undetectable		 3tkgB-2qu8A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1
(Plasmodium
falciparum) 		5 / 9 ILE A 136
GLY A  36
ILE A 115
VAL A 111
ILE A 145
 None
 1.04A 5kr2D-2qu8A:
undetectable		 5kr2D-2qu8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1
(Plasmodium
falciparum) 		3 / 3 SER A  43
LYS A  42
SER A  44
 GDP  A 229 (-2.9A)
GDP  A 229 (-2.6A)
GDP  A 229 (-2.6A)
 0.83A 6az3P-2qu8A:
undetectable		 6az3P-2qu8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1
(Plasmodium
falciparum) 		5 / 12 ILE A 136
GLY A  36
ILE A 115
VAL A 111
ILE A 145
 None
 1.09A 6difA-2qu8A:
undetectable		 6difA-2qu8A:
17.56