SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 LEU A 534
ASP A 532
ASP A 494
GLY A 490
PHE A 525
 None
CA  A 616 ( 2.4A)
None
CA  A 614 ( 4.7A)
None
 1.24A 1d4sA-2quaA:
undetectable		 1d4sA-2quaA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 8 PHE A 565
GLY A 567
LEU A 407
PHE A 549
 None
 1.06A 1gsfA-2quaA:
undetectable		 1gsfA-2quaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 8 PHE A 565
GLY A 567
LEU A 407
PHE A 549
 None
 1.06A 1gsfB-2quaA:
undetectable		 1gsfB-2quaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 8 PHE A 565
GLY A 567
LEU A 407
PHE A 549
 None
 1.06A 1gsfD-2quaA:
undetectable		 1gsfD-2quaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 7 THR A 472
GLY A 432
LEU A 435
TYR A 485
 None
 0.94A 1gtiA-2quaA:
undetectable		 1gtiA-2quaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 8 ARG A 454
ALA A 447
GLY A 392
ILE A 381
ILE A 450
 None
None
CA  A 619 (-4.2A)
None
None
 1.24A 1hshD-2quaA:
undetectable		 1hshD-2quaA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 8 ARG A 454
ALA A 447
GLY A 392
ILE A 416
ILE A 450
 None
None
CA  A 619 (-4.2A)
None
None
 1.32A 1hshD-2quaA:
undetectable		 1hshD-2quaA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		6 / 12 ARG A 454
ALA A 447
ASP A 448
GLY A 392
ILE A 381
ILE A 450
 None
None
None
CA  A 619 (-4.2A)
None
None
 1.22A 1muiB-2quaA:
undetectable		 1muiB-2quaA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 HIS A 206
GLY A 205
GLY A 142
VAL A 202
VAL A 213
 None
 1.24A 1n2xA-2quaA:
2.1		 1n2xA-2quaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 GLY A 198
ILE A 136
ALA A 135
GLN A 230
SER A 231
 None
 1.11A 1ri4A-2quaA:
undetectable		 1ri4A-2quaA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		6 / 12 ARG A 454
ALA A 447
ASP A 448
GLY A 392
ILE A 381
ILE A 450
 None
None
None
CA  A 619 (-4.2A)
None
None
 1.29A 1rl8A-2quaA:
undetectable		 1rl8A-2quaA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		6 / 12 ARG A 454
ALA A 447
ASP A 448
GLY A 392
ILE A 381
ILE A 450
 None
None
None
CA  A 619 (-4.2A)
None
None
 1.25A 1rl8B-2quaA:
undetectable		 1rl8B-2quaA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 GLY A 165
PRO A 239
VAL A 258
ILE A 305
 None
 0.92A 2aoiA-2quaA:
undetectable		 2aoiA-2quaA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		3 / 3 GLY A   2
GLU A  11
ASP A 336
 None
 0.44A 2b25B-2quaA:
undetectable		 2b25B-2quaA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 7 ALA A 409
GLY A 411
GLY A 410
ASN A 415
PHE A 331
 None
CA  A 618 ( 4.2A)
CA  A 618 (-4.6A)
CA  A 618 (-2.8A)
None
 1.34A 2c49B-2quaA:
undetectable		 2c49B-2quaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.43A 2eijG-2quaA:
0.0
2eijN-2quaA:
0.0
2eijO-2quaA:
0.5		 2eijG-2quaA:
9.09
2eijN-2quaA:
21.91
2eijO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.44A 2eikG-2quaA:
0.0
2eikN-2quaA:
0.0
2eikO-2quaA:
0.5		 2eikG-2quaA:
9.09
2eikN-2quaA:
21.91
2eikO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 8 LEU A 588
GLN A 594
PHE A 565
LEU A 563
PHE A 557
 None
 1.47A 2eilP-2quaA:
undetectable
2eilW-2quaA:
undetectable		 2eilP-2quaA:
17.87
2eilW-2quaA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		3 / 3 VAL A  91
TRP A  89
VAL A  84
 None
 0.98A 2izqC-2quaA:
undetectable
2izqD-2quaA:
undetectable		 2izqC-2quaA:
2.55
2izqD-2quaA:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		6 / 12 ARG A 454
ALA A 447
ASP A 448
GLY A 392
ILE A 381
ILE A 450
 None
None
None
CA  A 619 (-4.2A)
None
None
 1.45A 2nmyA-2quaA:
undetectable		 2nmyA-2quaA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 GLY A  44
GLY A  39
THR A  52
LEU A  51
VAL A 349
 None
 1.04A 2oxtC-2quaA:
undetectable		 2oxtC-2quaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		6 / 12 GLY A  44
GLY A  39
THR A  52
LEU A  51
GLU A  38
VAL A 349
 None
 1.09A 2oxtD-2quaA:
undetectable		 2oxtD-2quaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 ARG A 454
ALA A 447
ASP A 448
GLY A 392
ILE A 450
 None
None
None
CA  A 619 (-4.2A)
None
 1.03A 2qhcA-2quaA:
undetectable		 2qhcA-2quaA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 LEU A 586
VAL A 600
GLY A 599
ASP A 585
LEU A 588
 None
 0.90A 2v3kA-2quaA:
undetectable		 2v3kA-2quaA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 ALA A 188
VAL A 187
THR A 176
PHE A 140
ILE A 138
 None
 1.15A 2v95A-2quaA:
undetectable		 2v95A-2quaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 8 LEU A 497
LEU A 506
ALA A 487
HIS A 518
 None
 1.05A 2wekA-2quaA:
undetectable		 2wekA-2quaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 8 TYR A 436
VAL A 428
SER A 546
TYR A 485
 None
 1.32A 2y05A-2quaA:
undetectable
2y05B-2quaA:
undetectable		 2y05A-2quaA:
18.60
2y05B-2quaA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_G_CHDG1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.36A 2y69G-2quaA:
0.0
2y69N-2quaA:
0.0
2y69O-2quaA:
0.6		 2y69G-2quaA:
9.72
2y69N-2quaA:
21.91
2y69O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 THR A 118
GLY A 142
GLY A 145
LEU A 262
THR A 240
 CA  A 621 (-4.8A)
None
CA  A 621 ( 4.1A)
None
None
 1.07A 2y7hC-2quaA:
undetectable		 2y7hC-2quaA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.40A 3abkA-2quaA:
0.0
3abkB-2quaA:
0.5
3abkT-2quaA:
0.0		 3abkA-2quaA:
21.91
3abkB-2quaA:
15.42
3abkT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.41A 3abkG-2quaA:
0.0
3abkN-2quaA:
0.0
3abkO-2quaA:
0.5		 3abkG-2quaA:
9.09
3abkN-2quaA:
21.91
3abkO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.38A 3ablA-2quaA:
0.0
3ablB-2quaA:
0.5
3ablT-2quaA:
0.0		 3ablA-2quaA:
21.91
3ablB-2quaA:
15.42
3ablT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.38A 3ablG-2quaA:
0.0
3ablN-2quaA:
0.0
3ablO-2quaA:
0.5		 3ablG-2quaA:
9.09
3ablN-2quaA:
21.91
3ablO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.38A 3abmA-2quaA:
0.0
3abmB-2quaA:
0.5
3abmT-2quaA:
0.0		 3abmA-2quaA:
21.91
3abmB-2quaA:
15.42
3abmT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.35A 3abmG-2quaA:
0.0
3abmN-2quaA:
0.0
3abmO-2quaA:
0.5		 3abmG-2quaA:
9.09
3abmN-2quaA:
21.91
3abmO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 8 VAL A 123
LEU A 133
GLY A 125
TYR A 127
 None
 1.05A 3af0A-2quaA:
undetectable		 3af0A-2quaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.39A 3ag1G-2quaA:
0.0
3ag1N-2quaA:
0.0
3ag1O-2quaA:
0.4		 3ag1G-2quaA:
9.09
3ag1N-2quaA:
21.91
3ag1O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_G_CHDG86_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.40A 3ag2G-2quaA:
0.0
3ag2N-2quaA:
0.0
3ag2O-2quaA:
0.5		 3ag2G-2quaA:
9.09
3ag2N-2quaA:
21.91
3ag2O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.41A 3ag3G-2quaA:
0.0
3ag3N-2quaA:
0.0
3ag3O-2quaA:
0.0		 3ag3G-2quaA:
9.09
3ag3N-2quaA:
21.91
3ag3O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.41A 3ag4G-2quaA:
0.0
3ag4N-2quaA:
0.0
3ag4O-2quaA:
0.5		 3ag4G-2quaA:
9.09
3ag4N-2quaA:
21.91
3ag4O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 ILE A 308
PHE A 166
LEU A 162
ALA A 261
SER A 304
 None
 1.37A 3apwB-2quaA:
undetectable		 3apwB-2quaA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.38A 3asnA-2quaA:
0.0
3asnB-2quaA:
0.5
3asnT-2quaA:
0.0		 3asnA-2quaA:
21.91
3asnB-2quaA:
15.42
3asnT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.38A 3asoA-2quaA:
0.0
3asoB-2quaA:
0.5
3asoT-2quaA:
0.0		 3asoA-2quaA:
21.91
3asoB-2quaA:
15.42
3asoT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 8 LEU A 588
GLN A 594
PHE A 565
LEU A 563
PHE A 557
 None
 1.46A 3asoC-2quaA:
undetectable
3asoJ-2quaA:
undetectable		 3asoC-2quaA:
17.87
3asoJ-2quaA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.37A 3asoG-2quaA:
0.0
3asoN-2quaA:
0.0
3asoO-2quaA:
0.5		 3asoG-2quaA:
9.09
3asoN-2quaA:
21.91
3asoO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 GLY A 567
GLY A 547
THR A 434
LEU A 435
ILE A 408
 None
 1.02A 3eluA-2quaA:
undetectable		 3eluA-2quaA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 GLY A 567
GLY A 547
THR A 434
LEU A 435
ILE A 408
 None
 1.00A 3embA-2quaA:
undetectable		 3embA-2quaA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 GLY A 556
LEU A 597
LEU A 534
SER A 560
GLY A 540
 None
 1.04A 3g2oA-2quaA:
undetectable		 3g2oA-2quaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 GLY A 556
LEU A 597
LEU A 534
SER A 560
GLY A 540
 None
 1.03A 3g2oB-2quaA:
undetectable		 3g2oB-2quaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		3 / 3 ASP A 336
PHE A 371
SER A 367
 None
 0.92A 3i5uB-2quaA:
undetectable		 3i5uB-2quaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 ILE A 136
SER A  90
LYS A 126
GLY A 125
LEU A 196
 None
 1.15A 3ik6B-2quaA:
undetectable
3ik6E-2quaA:
undetectable		 3ik6B-2quaA:
17.91
3ik6E-2quaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 LEU A 196
ILE A 136
SER A  90
LYS A 126
GLY A 125
 None
 1.09A 3ik6B-2quaA:
undetectable
3ik6E-2quaA:
undetectable		 3ik6B-2quaA:
17.91
3ik6E-2quaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 ILE A 136
SER A  90
LYS A 126
GLY A 125
LEU A 196
 None
 1.13A 3iluB-2quaA:
undetectable
3iluE-2quaA:
undetectable		 3iluB-2quaA:
17.91
3iluE-2quaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		6 / 12 ARG A 454
ALA A 447
ASP A 448
GLY A 392
ILE A 381
ILE A 450
 None
None
None
CA  A 619 (-4.2A)
None
None
 1.45A 3ndtB-2quaA:
undetectable		 3ndtB-2quaA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		6 / 12 ARG A 454
ALA A 447
ASP A 448
GLY A 392
ILE A 416
ILE A 450
 None
None
None
CA  A 619 (-4.2A)
None
None
 1.46A 3s54A-2quaA:
undetectable		 3s54A-2quaA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.36A 3wg7A-2quaA:
0.0
3wg7B-2quaA:
0.5
3wg7T-2quaA:
0.0		 3wg7A-2quaA:
21.91
3wg7B-2quaA:
15.42
3wg7T-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.38A 3wg7G-2quaA:
0.0
3wg7N-2quaA:
0.0
3wg7O-2quaA:
0.0		 3wg7G-2quaA:
9.09
3wg7N-2quaA:
21.91
3wg7O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.43A 3x2qG-2quaA:
0.0
3x2qN-2quaA:
0.0
3x2qO-2quaA:
0.5		 3x2qG-2quaA:
9.09
3x2qN-2quaA:
21.91
3x2qO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 6 GLY A 111
ALA A 119
TYR A 110
GLU A 122
 None
 0.95A 4ae1A-2quaA:
undetectable		 4ae1A-2quaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 7 PRO A 257
SER A 313
TRP A 311
HIS A 292
 None
 1.05A 4k7gB-2quaA:
undetectable		 4k7gB-2quaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 9 ARG A 454
ALA A 447
ASP A 448
GLY A 392
ILE A 450
 None
None
None
CA  A 619 (-4.2A)
None
 1.14A 4ll3B-2quaA:
undetectable		 4ll3B-2quaA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 6 ILE A 286
ILE A 373
SER A 329
PHE A   4
 None
 0.95A 4m51A-2quaA:
undetectable		 4m51A-2quaA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 GLY A 205
ALA A  28
PHE A 140
GLU A 122
 None
 1.04A 4m93B-2quaA:
undetectable
4m93C-2quaA:
undetectable		 4m93B-2quaA:
15.28
4m93C-2quaA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		3 / 3 ASP A 276
ASN A 255
SER A 367
 CA  A 620 (-2.1A)
None
None
 0.81A 4obwA-2quaA:
3.2		 4obwA-2quaA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 THR A 283
SER A 281
ASP A 338
TYR A 253
GLY A 252
 None
 1.46A 4qb9C-2quaA:
1.4		 4qb9C-2quaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 THR A 283
SER A 281
ASP A 338
TYR A 253
GLY A 252
 None
 1.43A 4qb9E-2quaA:
0.1		 4qb9E-2quaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 8 THR A 240
GLY A 210
GLY A 209
ASP A 157
 None
None
None
CA  A 621 (-2.1A)
 0.67A 4qvvK-2quaA:
undetectable
4qvvL-2quaA:
undetectable		 4qvvK-2quaA:
17.91
4qvvL-2quaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 8 THR A 240
GLY A 210
GLY A 209
ASP A 157
 None
None
None
CA  A 621 (-2.1A)
 0.67A 4qvvY-2quaA:
undetectable
4qvvZ-2quaA:
undetectable		 4qvvY-2quaA:
17.91
4qvvZ-2quaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 PHE A  36
ALA A  56
THR A 350
LEU A  49
LEU A 312
 None
 1.22A 4qztC-2quaA:
undetectable		 4qztC-2quaA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 PHE A  36
ALA A  56
THR A 350
LEU A  49
LEU A 312
 None
 1.32A 4qzuA-2quaA:
undetectable		 4qzuA-2quaA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 4 ASN A 285
LEU A 323
PHE A 371
TYR A 332
 CA  A 620 (-3.3A)
None
None
None
 1.41A 4u14A-2quaA:
0.0		 4u14A-2quaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.38A 5b1aA-2quaA:
0.0
5b1aB-2quaA:
0.5
5b1aT-2quaA:
0.0		 5b1aA-2quaA:
21.91
5b1aB-2quaA:
15.42
5b1aT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.36A 5b1aG-2quaA:
0.0
5b1aN-2quaA:
0.0
5b1aO-2quaA:
0.4		 5b1aG-2quaA:
9.09
5b1aN-2quaA:
21.91
5b1aO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.43A 5b1bA-2quaA:
0.0
5b1bB-2quaA:
0.5
5b1bT-2quaA:
0.0		 5b1bA-2quaA:
21.91
5b1bB-2quaA:
15.42
5b1bT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.40A 5b1bG-2quaA:
0.0
5b1bN-2quaA:
0.0
5b1bO-2quaA:
0.0		 5b1bG-2quaA:
9.09
5b1bN-2quaA:
21.91
5b1bO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.40A 5b3sA-2quaA:
0.0
5b3sB-2quaA:
0.5
5b3sT-2quaA:
0.0		 5b3sA-2quaA:
21.91
5b3sB-2quaA:
15.42
5b3sT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.37A 5b3sG-2quaA:
0.0
5b3sN-2quaA:
0.0
5b3sO-2quaA:
0.5		 5b3sG-2quaA:
9.09
5b3sN-2quaA:
21.91
5b3sO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 6 SER A 231
GLU A 199
GLY A 181
GLY A 185
 None
 0.69A 5cdnA-2quaA:
undetectable
5cdnB-2quaA:
undetectable		 5cdnA-2quaA:
22.20
5cdnB-2quaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 6 SER A 231
GLU A 199
GLY A 181
GLY A 185
 None
 0.71A 5cdnR-2quaA:
undetectable
5cdnS-2quaA:
undetectable		 5cdnR-2quaA:
22.20
5cdnS-2quaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		6 / 12 ARG A 454
ALA A 447
ASP A 448
GLY A 392
ILE A 416
ILE A 450
 None
None
None
CA  A 619 (-4.2A)
None
None
 1.44A 5e5jB-2quaA:
undetectable		 5e5jB-2quaA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 9 VAL A 201
TYR A 228
ILE A 138
VAL A 123
LEU A  97
 None
 1.22A 5fxfA-2quaA:
0.0		 5fxfA-2quaA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 VAL A 201
TYR A 228
ILE A 138
VAL A 123
LEU A  97
 None
 1.23A 5fxfB-2quaA:
0.0		 5fxfB-2quaA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 0.93A 5hm8A-2quaA:
3.5		 5hm8A-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 0.93A 5hm8B-2quaA:
3.4		 5hm8B-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 0.93A 5hm8C-2quaA:
3.5		 5hm8C-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 0.93A 5hm8D-2quaA:
3.5		 5hm8D-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 0.93A 5hm8E-2quaA:
undetectable		 5hm8E-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 0.93A 5hm8F-2quaA:
undetectable		 5hm8F-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 1.02A 5hm8G-2quaA:
undetectable		 5hm8G-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 0.93A 5hm8H-2quaA:
undetectable		 5hm8H-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 6 ASP A 379
GLY A 377
ASP A 376
ASP A 397
 CA  A 619 (-3.2A)
CA  A 619 (-4.4A)
None
CA  A 619 ( 2.2A)
 1.34A 5hp1A-2quaA:
undetectable		 5hp1A-2quaA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 LEU A  97
GLN A  96
PHE A 190
LEU A 196
GLY A 137
 None
 1.43A 5i8fA-2quaA:
undetectable		 5i8fA-2quaA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 GLY A 210
TYR A 175
ASP A 153
ALA A 179
TYR A  29
 None
None
CA  A 621 (-2.9A)
None
None
 1.21A 5igvA-2quaA:
undetectable		 5igvA-2quaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_T_CHDT103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.38A 5iy5A-2quaA:
0.0
5iy5B-2quaA:
0.5
5iy5T-2quaA:
0.0		 5iy5A-2quaA:
21.91
5iy5B-2quaA:
15.42
5iy5T-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 THR A 524
GLU A 427
THR A 426
LEU A 435
 None
 0.84A 5utuH-2quaA:
3.2		 5utuH-2quaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 ALA A  16
SER A  19
ILE A  24
VAL A 234
PHE A 236
 None
 1.25A 5vlmB-2quaA:
undetectable		 5vlmB-2quaA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.40A 5w97G-2quaA:
0.0
5w97a-2quaA:
0.0
5w97b-2quaA:
0.0		 5w97G-2quaA:
9.09
5w97a-2quaA:
21.91
5w97b-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.41A 5w97A-2quaA:
0.0
5w97B-2quaA:
0.0
5w97g-2quaA:
0.0		 5w97A-2quaA:
21.91
5w97B-2quaA:
15.42
5w97g-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.37A 5wauA-2quaA:
0.0
5wauB-2quaA:
0.5
5waug-2quaA:
0.0		 5wauA-2quaA:
21.91
5wauB-2quaA:
15.42
5waug-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.35A 5x19A-2quaA:
0.0
5x19B-2quaA:
0.4
5x19T-2quaA:
0.0		 5x19A-2quaA:
21.91
5x19B-2quaA:
15.42
5x19T-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.40A 5x19G-2quaA:
0.0
5x19N-2quaA:
0.0
5x19O-2quaA:
0.5		 5x19G-2quaA:
9.09
5x19N-2quaA:
21.91
5x19O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.38A 5xdqA-2quaA:
0.0
5xdqB-2quaA:
0.5
5xdqT-2quaA:
0.0		 5xdqA-2quaA:
21.91
5xdqB-2quaA:
15.42
5xdqT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.38A 5xdqG-2quaA:
0.0
5xdqN-2quaA:
0.0
5xdqO-2quaA:
0.5		 5xdqG-2quaA:
9.09
5xdqN-2quaA:
21.91
5xdqO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.36A 5xdxA-2quaA:
0.0
5xdxB-2quaA:
0.0
5xdxT-2quaA:
0.0		 5xdxA-2quaA:
21.91
5xdxB-2quaA:
15.42
5xdxT-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_O_CHDO301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.37A 5xdxG-2quaA:
0.0
5xdxN-2quaA:
0.0
5xdxO-2quaA:
0.5		 5xdxG-2quaA:
9.09
5xdxN-2quaA:
21.91
5xdxO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.44A 5z84A-2quaA:
0.0
5z84B-2quaA:
0.5
5z84T-2quaA:
0.0		 5z84A-2quaA:
21.91
5z84B-2quaA:
15.42
5z84T-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_G_CHDG101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.42A 5z84G-2quaA:
0.0
5z84N-2quaA:
0.0
5z84O-2quaA:
0.5		 5z84G-2quaA:
9.09
5z84N-2quaA:
21.91
5z84O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.44A 5z85G-2quaA:
0.0
5z85N-2quaA:
0.0
5z85O-2quaA:
0.5		 5z85G-2quaA:
9.09
5z85N-2quaA:
21.91
5z85O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 11 GLY A 181
GLU A 112
THR A 117
THR A 113
GLY A 174
 None
 1.44A 5z86A-2quaA:
0.0
5z86B-2quaA:
0.5
5z86T-2quaA:
0.0		 5z86A-2quaA:
21.91
5z86B-2quaA:
15.42
5z86T-2quaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.44A 5z86G-2quaA:
0.0
5z86N-2quaA:
0.0
5z86O-2quaA:
0.5		 5z86G-2quaA:
9.09
5z86N-2quaA:
21.91
5z86O-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 7 LEU A 588
GLN A 594
PHE A 565
LEU A 563
PHE A 557
 None
 1.49A 5zcoC-2quaA:
undetectable
5zcoJ-2quaA:
undetectable		 5zcoC-2quaA:
17.87
5zcoJ-2quaA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.36A 5zcoG-2quaA:
0.0
5zcoN-2quaA:
0.0
5zcoO-2quaA:
0.5		 5zcoG-2quaA:
9.09
5zcoN-2quaA:
21.91
5zcoO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 7 GLY A 493
GLY A 491
GLY A 508
GLY A 527
GLY A 528
 CA  A 614 (-4.3A)
CA  A 614 (-4.3A)
CA  A 614 (-4.3A)
CA  A 616 (-4.4A)
CA  A 616 (-4.3A)
 1.06A 6ag0A-2quaA:
undetectable		 6ag0A-2quaA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 GLY A 392
ASP A 397
ASP A 396
ASP A 449
ALA A 409
 CA  A 619 (-4.2A)
CA  A 619 ( 2.2A)
None
None
None
 1.05A 6bq4B-2quaA:
undetectable		 6bq4B-2quaA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 ARG A 454
ALA A 447
ASP A 448
ILE A 381
ILE A 450
 None
 1.06A 6difA-2quaA:
undetectable		 6difA-2quaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 6 TYR A 293
ASP A 276
VAL A 274
GLU A 254
 None
CA  A 620 (-2.1A)
None
CA  A 620 (-3.3A)
 1.23A 6djzB-2quaA:
undetectable		 6djzB-2quaA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		3 / 3 ARG A 147
HIS A  30
ARG A 141
 None
 1.17A 6dwdD-2quaA:
undetectable		 6dwdD-2quaA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 LEU A 390
GLY A 410
ASP A 376
ILE A 372
ILE A 381
 None
CA  A 618 (-4.6A)
None
None
None
 0.97A 6emuA-2quaA:
undetectable		 6emuA-2quaA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 TYR A 253
VAL A 248
MET A 324
GLY A 322
 None
 1.23A 6hd4A-2quaA:
undetectable		 6hd4A-2quaA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 5 GLY A 567
THR A 568
HIS A   0
SER A 572
 None
 0.89A 6jmjA-2quaA:
undetectable		 6jmjA-2quaA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 7 GLY A 567
THR A 568
HIS A   0
SER A 572
 None
 0.93A 6jnhA-2quaA:
undetectable		 6jnhA-2quaA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		4 / 6 GLY A 567
THR A 568
HIS A   0
SER A 572
 None
 0.90A 6jogA-2quaA:
undetectable		 6jogA-2quaA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 9 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.41A 6nknG-2quaA:
0.0
6nknN-2quaA:
0.0
6nknO-2quaA:
0.5		 6nknG-2quaA:
9.09
6nknN-2quaA:
21.91
6nknO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 10 GLY A 174
GLY A 181
GLU A 112
THR A 117
THR A 113
 None
 1.46A 6nmpG-2quaA:
0.0
6nmpN-2quaA:
0.0
6nmpO-2quaA:
0.4		 6nmpG-2quaA:
9.09
6nmpN-2quaA:
21.91
6nmpO-2quaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 ILE A 138
GLY A 205
PHE A 140
ILE A  24
ALA A  23
 None
 1.29A 6qyaB-2quaA:
undetectable		 6qyaB-2quaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 ILE A 138
LEU A  17
GLY A 205
PHE A 140
ILE A  24
 None
 1.38A 6qyaB-2quaA:
undetectable		 6qyaB-2quaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2qua EXTRACELLULAR LIPASE
(Serratia
marcescens) 		5 / 12 ILE A 138
GLY A 205
PHE A 140
ILE A  24
ALA A  23
 None
 1.32A 6qyaD-2quaA:
undetectable		 6qyaD-2quaA:
19.39