SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2quy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 10 ASP A  69
GLY A  70
ARG A  17
TYR A 278
GLY A  56
 None
 1.13A 1fohA-2quyA:
undetectable		 1fohA-2quyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 10 ASP A  69
GLY A  70
ARG A  17
TYR A 278
GLY A  56
 None
 1.17A 1fohB-2quyA:
undetectable		 1fohB-2quyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		3 / 3 PHE A 138
TYR A  82
PRO A 140
 None
 1.18A 1mcnA-2quyA:
undetectable
1mcnB-2quyA:
undetectable
1mcnP-2quyA:
undetectable		 1mcnA-2quyA:
20.47
1mcnB-2quyA:
20.47
1mcnP-2quyA:
0.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 9 THR A 279
THR A 174
LEU A 256
VAL A 232
ASP A  20
 None
 1.50A 1t86B-2quyA:
undetectable		 1t86B-2quyA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 12 CYH A   1
ARG A  17
MET A  19
ILE A  62
ILE A 134
 None
 0.92A 2bjfA-2quyA:
42.9		 2bjfA-2quyA:
36.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		4 / 8 LEU A 252
SER A 153
VAL A  71
GLY A  70
 None
 0.94A 2qd5A-2quyA:
undetectable		 2qd5A-2quyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		4 / 8 LEU A 252
SER A 153
VAL A  71
GLY A  70
 None
 0.97A 2qd5B-2quyA:
undetectable		 2qd5B-2quyA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		6 / 10 THR A  22
TYR A  82
PRO A 225
ARG A 228
ASN A 269
ASP A 274
 None
None
CL  A 336 ( 4.2A)
CL  A 336 (-3.2A)
None
None
 0.35A 2z71A-2quyA:
53.8
2z71C-2quyA:
54.5		 2z71A-2quyA:
99.40
2z71C-2quyA:
99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z71_C_PNVC904_1
(PENICILLIN ACYLASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 10 ARG A 228
THR A 268
ASN A 269
LYS A 272
ASP A 274
 CL  A 336 (-3.2A)
None
None
None
None
 0.86A 2z71A-2quyA:
53.8
2z71C-2quyA:
54.5		 2z71A-2quyA:
99.40
2z71C-2quyA:
99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z71_C_PNVC904_1
(PENICILLIN ACYLASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 10 TYR A  82
ARG A 228
THR A 268
ASN A 269
ASP A 274
 None
CL  A 336 (-3.2A)
None
None
None
 0.76A 2z71A-2quyA:
53.8
2z71C-2quyA:
54.5		 2z71A-2quyA:
99.40
2z71C-2quyA:
99.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		4 / 7 THR A 246
VAL A 249
THR A 250
ILE A 299
 None
 0.84A 3deuA-2quyA:
undetectable		 3deuA-2quyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		4 / 5 ASN A 288
ALA A  53
LEU A  67
GLY A  56
 None
 0.87A 3dl9A-2quyA:
undetectable		 3dl9A-2quyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		3 / 3 THR A  63
SER A  64
ARG A  39
 None
 0.69A 3phnA-2quyA:
undetectable		 3phnA-2quyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 11 LEU A   4
ALA A  16
THR A 276
ILE A 261
ASP A  20
 None
 1.19A 4uuuA-2quyA:
undetectable
4uuuB-2quyA:
undetectable		 4uuuA-2quyA:
18.61
4uuuB-2quyA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 11 LEU A   4
ALA A  16
THR A 276
ILE A 261
ASP A  20
 None
 1.20A 4uuuB-2quyA:
undetectable		 4uuuB-2quyA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 11 HIS A 182
VAL A 155
LEU A  81
THR A 174
ALA A 175
 None
None
None
None
CL  A 336 ( 4.3A)
 1.39A 4ygfD-2quyA:
undetectable		 4ygfD-2quyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 12 HIS A 182
VAL A 155
LEU A  81
THR A 174
ALA A 175
 None
None
None
None
CL  A 336 ( 4.3A)
 1.39A 4ygfG-2quyA:
undetectable		 4ygfG-2quyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 10 HIS A 182
VAL A 155
LEU A  81
THR A 174
ALA A 175
 None
None
None
None
CL  A 336 ( 4.3A)
 1.48A 4yhaB-2quyA:
undetectable		 4yhaB-2quyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		3 / 3 VAL A  47
GLU A 131
GLU A  42
 None
 0.91A 5jsdB-2quyA:
0.1
5jsdC-2quyA:
0.7		 5jsdB-2quyA:
18.19
5jsdC-2quyA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 12 SER A 280
GLY A  78
GLY A  70
ASP A 148
ALA A  16
 None
 1.07A 5kpcB-2quyA:
undetectable		 5kpcB-2quyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 9 HIS A 182
VAL A 155
LEU A  81
THR A 174
ALA A 175
 None
None
None
None
CL  A 336 ( 4.3A)
 1.39A 5tt3E-2quyA:
undetectable		 5tt3E-2quyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 8 HIS A 182
VAL A 155
LEU A  81
THR A 174
ALA A 175
 None
None
None
None
CL  A 336 ( 4.3A)
 1.43A 5tt3H-2quyA:
undetectable		 5tt3H-2quyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 11 ILE A  30
SER A  64
PRO A  33
LEU A  67
SER A 107
 None
 1.36A 6dlzA-2quyA:
undetectable
6dlzD-2quyA:
undetectable		 6dlzA-2quyA:
16.61
6dlzD-2quyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2quy PENICILLIN ACYLASE
(Lysinibacillus
sphaericus) 		5 / 11 ILE A  30
SER A  64
PRO A  33
LEU A  67
SER A 107
 None
 1.36A 6dm1A-2quyA:
undetectable
6dm1D-2quyA:
undetectable		 6dm1A-2quyA:
16.61
6dm1D-2quyA:
16.61