SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 5 THR A  85
LEU A  87
GLY A  90
TYR A 116
 THR  A  85 ( 0.8A)
LEU  A  87 ( 0.6A)
GLY  A  90 ( 0.0A)
TYR  A 116 ( 1.3A)
 1.19A 1gtiF-2qv2A:
undetectable		 1gtiF-2qv2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 7 GLU A 147
LEU A 146
GLU A 148
GLU A 153
 GLU  A 147 ( 0.6A)
LEU  A 146 ( 0.6A)
GLU  A 148 ( 0.6A)
GLU  A 153 ( 0.5A)
 0.89A 1linA-2qv2A:
undetectable		 1linA-2qv2A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 11 VAL A 296
LEU A 336
LEU A 288
LEU A 309
LEU A 332
 VAL  A 296 ( 0.6A)
LEU  A 336 ( 0.6A)
LEU  A 288 ( 0.6A)
LEU  A 309 ( 0.6A)
LEU  A 332 ( 0.6A)
 1.40A 1mx1B-2qv2A:
undetectable		 1mx1B-2qv2A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		3 / 3 LEU A 310
PHE A 331
ARG A 274
 LEU  A 310 ( 0.6A)
PHE  A 331 ( 1.3A)
ARG  A 274 ( 0.6A)
 0.72A 1xdkB-2qv2A:
undetectable		 1xdkB-2qv2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		3 / 3 LEU A 310
PHE A 331
ARG A 274
 LEU  A 310 ( 0.6A)
PHE  A 331 ( 1.3A)
ARG  A 274 ( 0.6A)
 0.72A 1xdkF-2qv2A:
undetectable		 1xdkF-2qv2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 6 ARG A 274
PHE A 277
ILE A 244
PHE A 331
 ARG  A 274 ( 0.6A)
PHE  A 277 ( 1.3A)
ILE  A 244 ( 0.7A)
PHE  A 331 ( 1.3A)
 1.28A 2qeiA-2qv2A:
undetectable		 2qeiA-2qv2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 6 ILE A 301
ILE A 244
LEU A 288
MET A 281
 ILE  A 301 ( 0.7A)
ILE  A 244 ( 0.7A)
LEU  A 288 ( 0.6A)
MET  A 281 ( 0.0A)
 1.01A 3adsA-2qv2A:
undetectable		 3adsA-2qv2A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 11 LEU A 310
VAL A 265
TYR A 257
LEU A 253
TYR A 249
 LEU  A 310 ( 0.6A)
VAL  A 265 ( 0.6A)
TYR  A 257 ( 1.3A)
LEU  A 253 ( 0.6A)
TYR  A 249 ( 1.3A)
 1.49A 3bgrA-2qv2A:
undetectable
3bgrB-2qv2A:
undetectable		 3bgrA-2qv2A:
20.63
3bgrB-2qv2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 8 PHE A  13
PHE A  15
PHE A  28
ALA A  58
 PHE  A  13 ( 1.3A)
PHE  A  15 ( 1.3A)
PHE  A  28 ( 1.3A)
ALA  A  58 ( 0.0A)
 0.95A 3t3sF-2qv2A:
undetectable		 3t3sF-2qv2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		3 / 3 LYS A 188
ASN A 294
ASP A 184
 LYS  A 188 ( 0.0A)
ASN  A 294 ( 0.6A)
ASP  A 184 ( 0.5A)
 0.79A 4o1eA-2qv2A:
undetectable		 4o1eA-2qv2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 11 LEU A 280
LEU A 236
GLU A 230
ALA A 229
LEU A 232
 LEU  A 280 ( 0.6A)
LEU  A 236 ( 0.6A)
GLU  A 230 ( 0.6A)
ALA  A 229 ( 0.0A)
LEU  A 232 ( 0.6A)
 0.75A 4wg0J-2qv2A:
undetectable
4wg0K-2qv2A:
undetectable
4wg0L-2qv2A:
undetectable		 4wg0J-2qv2A:
3.69
4wg0K-2qv2A:
3.69
4wg0L-2qv2A:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		5 / 9 LEU A 173
LEU A 213
GLU A 178
VAL A 183
PHE A 235
 LEU  A 173 ( 0.6A)
LEU  A 213 ( 0.6A)
GLU  A 178 ( 0.5A)
VAL  A 183 ( 0.6A)
PHE  A 235 ( 1.3A)
 1.44A 4wnvB-2qv2A:
undetectable		 4wnvB-2qv2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens) 		4 / 7 ILE A 221
LEU A 186
ALA A 231
ILE A 209
 ILE  A 221 ( 0.7A)
LEU  A 186 ( 0.6A)
ALA  A 231 ( 0.0A)
ILE  A 209 ( 0.7A)
 0.86A 4y03A-2qv2A:
undetectable		 4y03A-2qv2A:
16.37