SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 7 THR A 641
LEU A 645
SER A 624
VAL A 620
 None
 0.82A 1ictD-2qv3A:
undetectable		 1ictD-2qv3A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 12 ILE A 518
VAL A 509
LEU A 500
LEU A 567
ILE A 542
 None
 1.29A 1kqwA-2qv3A:
undetectable		 1kqwA-2qv3A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 8 THR A 591
ASP A 570
PHE A 572
LEU A 613
 None
 0.95A 1lhvA-2qv3A:
undetectable		 1lhvA-2qv3A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 7 THR A 641
LEU A 645
SER A 624
VAL A 620
 None
 0.70A 1tyrB-2qv3A:
undetectable		 1tyrB-2qv3A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 7 ILE A 590
LEU A 615
THR A 630
LEU A 629
 None
 0.92A 1v55A-2qv3A:
undetectable
1v55J-2qv3A:
undetectable		 1v55A-2qv3A:
22.20
1v55J-2qv3A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 8 ILE A 590
LEU A 615
THR A 630
LEU A 629
 None
 0.91A 1v55N-2qv3A:
undetectable
1v55W-2qv3A:
undetectable		 1v55N-2qv3A:
22.20
1v55W-2qv3A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 6 LEU A 629
LEU A 608
ILE A 631
ARG A 583
 None
 0.97A 2rlfC-2qv3A:
undetectable
2rlfD-2qv3A:
undetectable		 2rlfC-2qv3A:
9.50
2rlfD-2qv3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 7 THR A 502
THR A 478
ILE A 476
THR A 505
 None
 0.82A 3deuA-2qv3A:
undetectable		 3deuA-2qv3A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 6 THR A 502
THR A 478
LEU A 486
THR A 505
 None
 0.77A 3deuB-2qv3A:
undetectable		 3deuB-2qv3A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 10 TYR A 703
ILE A 679
ILE A 787
GLY A 784
VAL A 656
 None
 1.37A 3elzB-2qv3A:
undetectable		 3elzB-2qv3A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 10 ILE A 514
PHE A 512
ILE A 476
THR A 502
VAL A 559
 None
 0.93A 3eqmA-2qv3A:
undetectable		 3eqmA-2qv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 12 ILE A 514
PHE A 512
ILE A 476
THR A 502
VAL A 559
 None
 0.91A 3s79A-2qv3A:
undetectable		 3s79A-2qv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 6 THR A 478
GLY A 481
ASN A 484
GLY A 557
 None
 0.90A 4fjpA-2qv3A:
undetectable		 4fjpA-2qv3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 5 TYR A 767
ILE A 769
ASN A 764
ILE A 746
 None
 1.04A 4jtpA-2qv3A:
undetectable		 4jtpA-2qv3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 10 ALA A 752
ILE A 746
PRO A 797
THR A 796
ILE A 753
 None
 0.94A 4njuB-2qv3A:
undetectable		 4njuB-2qv3A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 10 ALA A 752
ILE A 746
PRO A 797
THR A 796
ILE A 753
 None
 0.93A 4njuD-2qv3A:
undetectable		 4njuD-2qv3A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 12 GLY A 479
GLY A 481
GLY A 459
LEU A 458
LEU A 500
 None
 0.97A 5c0oF-2qv3A:
undetectable		 5c0oF-2qv3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 12 ILE A 514
PHE A 512
ILE A 476
THR A 502
VAL A 559
 None
 0.91A 5jkvA-2qv3A:
undetectable		 5jkvA-2qv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 11 ILE A 514
PHE A 512
ILE A 476
THR A 502
VAL A 559
 None
 0.93A 5jkwA-2qv3A:
undetectable		 5jkwA-2qv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 10 ILE A 514
PHE A 512
ILE A 476
THR A 502
VAL A 559
 None
 0.93A 5jl7A-2qv3A:
undetectable		 5jl7A-2qv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		3 / 3 LYS A 566
GLN A 617
ASN A 638
 None
 1.09A 5l2tA-2qv3A:
undetectable		 5l2tA-2qv3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		5 / 12 ARG A 541
PHE A 610
PHE A 580
ILE A 590
GLY A 564
 None
 1.06A 5veuH-2qv3A:
undetectable		 5veuH-2qv3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 2qv3 VACUOLATING
CYTOTOXIN
(Helicobacter
pylori) 		4 / 4 PHE A 488
ASP A 467
LEU A 486
LYS A 465
 None
 1.38A 6awvA-2qv3A:
undetectable		 6awvA-2qv3A:
16.85