SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 198
ASP A 199
ILE A 137
THR A 247
ILE A 216
 None
 1.40A 1hzeA-2qv6A:
undetectable
1hzeB-2qv6A:
undetectable		 1hzeA-2qv6A:
17.36
1hzeB-2qv6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 9 THR A 247
ILE A 216
LEU A 198
ASP A 199
ILE A 137
 None
 1.40A 1hzeA-2qv6A:
undetectable
1hzeB-2qv6A:
undetectable		 1hzeA-2qv6A:
17.36
1hzeB-2qv6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 10 THR A 247
ILE A 216
LEU A 198
ASP A 199
ILE A 137
 None
 1.42A 1i18A-2qv6A:
undetectable
1i18B-2qv6A:
undetectable		 1i18A-2qv6A:
17.36
1i18B-2qv6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  64
ALA A  44
PHE A  42
SER A  75
ILE A  76
 None
 1.24A 1j3jA-2qv6A:
undetectable		 1j3jA-2qv6A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  18
THR A  16
PRO A  14
 None
 0.87A 1qfiB-2qv6A:
undetectable		 1qfiB-2qv6A:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A 210
ILE A 180
ILE A 142
LEU A 170
 None
GTP  A 300 (-3.8A)
GTP  A 300 (-4.1A)
None
 0.89A 1zgyA-2qv6A:
undetectable		 1zgyA-2qv6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  16
PRO A  14
THR A  18
 None
 0.77A 209dC-2qv6A:
undetectable		 209dC-2qv6A:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 4 ASP A  10
ASP A  55
ASP A 113
GLY A  13
 None
 1.41A 2igtC-2qv6A:
undetectable		 2igtC-2qv6A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A  35
LEU A  38
LEU A  57
ALA A  59
 None
 0.86A 2wekA-2qv6A:
undetectable		 2wekA-2qv6A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 166
ASP A 138
LEU A 233
HIS A 136
 None
CA  A 302 (-2.1A)
None
GTP  A 300 (-4.7A)
 1.21A 3bj8C-2qv6A:
undetectable
3bj8D-2qv6A:
undetectable		 3bj8C-2qv6A:
22.22
3bj8D-2qv6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 135
GLY A 217
SER A 226
SER A 189
LEU A 177
 None
 1.23A 3bxoA-2qv6A:
undetectable		 3bxoA-2qv6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 8 SER A  90
LEU A 126
LEU A  66
ASN A 124
VAL A 122
 None
 1.45A 3dcjB-2qv6A:
undetectable		 3dcjB-2qv6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  64
ALA A  44
PHE A  42
SER A  75
ILE A  76
 None
 1.28A 3qg2A-2qv6A:
undetectable		 3qg2A-2qv6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  64
ALA A  44
PHE A  42
SER A  75
ILE A  76
 None
 1.29A 3qgtA-2qv6A:
undetectable		 3qgtA-2qv6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 212
ILE A 142
GLY A 181
ILE A 180
ILE A 139
 None
GTP  A 300 (-4.1A)
GTP  A 300 ( 4.8A)
GTP  A 300 (-3.8A)
None
 1.00A 3s53B-2qv6A:
undetectable		 3s53B-2qv6A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 8 SER A 189
GLN A 133
ILE A 236
VAL A 241
 None
 1.00A 4dx7B-2qv6A:
5.4		 4dx7B-2qv6A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 228
ILE A 134
ILE A 231
GLY A 232
GLY A 215
 None
 0.95A 4fakA-2qv6A:
undetectable		 4fakA-2qv6A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 134
ALA A 225
GLY A 219
GLY A  63
LYS A   1
 None
 1.31A 4jdsC-2qv6A:
undetectable		 4jdsC-2qv6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 134
ALA A 225
GLY A 219
GLY A  63
LYS A   1
 None
 1.27A 4jlgA-2qv6A:
undetectable		 4jlgA-2qv6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A  85
GLU A 118
ASP A  10
ARG A  77
ILE A  76
 None
 1.26A 4uroD-2qv6A:
undetectable		 4uroD-2qv6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		3 / 3 ALA A  36
ASN A  39
LEU A  40
 None
 0.50A 5i1nC-2qv6A:
undetectable		 5i1nC-2qv6A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A  88
ILE A  76
LEU A  38
PHE A  42
 None
 0.93A 5vkqB-2qv6A:
undetectable
5vkqC-2qv6A:
undetectable		 5vkqB-2qv6A:
9.83
5vkqC-2qv6A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A  88
ILE A  76
LEU A  38
PHE A  42
 None
 0.93A 5vkqC-2qv6A:
undetectable
5vkqD-2qv6A:
undetectable		 5vkqC-2qv6A:
9.83
5vkqD-2qv6A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  58
GLN A  98
GLU A 103
VAL A   6
 None
 1.16A 6j20A-2qv6A:
undetectable		 6j20A-2qv6A:
20.09