SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2qvg TWO COMPONENT
RESPONSE REGULATOR
(Legionella
pneumophila) 		4 / 8 LYS A  40
ILE A  38
GLU A  17
ILE A  20
 None
 0.93A 2j9dJ-2qvgA:
undetectable
2j9dK-2qvgA:
undetectable
2j9dL-2qvgA:
undetectable		 2j9dJ-2qvgA:
21.53
2j9dK-2qvgA:
21.53
2j9dL-2qvgA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2qvg TWO COMPONENT
RESPONSE REGULATOR
(Legionella
pneumophila) 		4 / 5 ILE A  10
LEU A  64
GLU A  24
VAL A  18
 None
 1.07A 4nkxB-2qvgA:
undetectable		 4nkxB-2qvgA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2qvg TWO COMPONENT
RESPONSE REGULATOR
(Legionella
pneumophila) 		4 / 4 ILE A  63
ILE A  90
ARG A  82
LEU A  64
 None
 1.27A 5dzkh-2qvgA:
undetectable
5dzkn-2qvgA:
undetectable
5dzkv-2qvgA:
undetectable		 5dzkh-2qvgA:
20.98
5dzkn-2qvgA:
20.98
5dzkv-2qvgA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2qvg TWO COMPONENT
RESPONSE REGULATOR
(Legionella
pneumophila) 		4 / 6 LEU A 132
LEU A  62
LEU A  13
GLU A  37
 None
 0.89A 5tudD-2qvgA:
undetectable		 5tudD-2qvgA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2qvg TWO COMPONENT
RESPONSE REGULATOR
(Legionella
pneumophila) 		5 / 11 ILE A 117
GLY A 114
LEU A 120
THR A  96
LEU A  95
 None
 0.77A 5twjD-2qvgA:
undetectable		 5twjD-2qvgA:
27.17