SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qvk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2qvk SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 8 GLY A 544
THR A 545
ALA A 546
VAL A 514
 None
 0.79A 2a1hA-2qvkA:
undetectable
2a1hB-2qvkA:
undetectable		 2a1hA-2qvkA:
20.17
2a1hB-2qvkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2qvk SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 8 VAL A 514
GLY A 544
THR A 545
ALA A 546
 None
 0.79A 2a1hA-2qvkA:
undetectable
2a1hB-2qvkA:
undetectable		 2a1hA-2qvkA:
20.17
2a1hB-2qvkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 2qvk SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 8 VAL A 573
THR A 541
GLY A 544
THR A 586
ALA A 546
 None
 1.14A 2a1hA-2qvkA:
undetectable
2a1hB-2qvkA:
undetectable		 2a1hA-2qvkA:
20.17
2a1hB-2qvkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2qvk SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 10 THR A 541
GLY A 544
THR A 586
ALA A 546
VAL A 573
 None
 1.19A 2coiA-2qvkA:
undetectable
2coiB-2qvkA:
undetectable		 2coiA-2qvkA:
19.43
2coiB-2qvkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2qvk SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 10 VAL A 573
THR A 541
GLY A 544
THR A 586
ALA A 546
 None
 1.18A 2coiA-2qvkA:
undetectable
2coiB-2qvkA:
undetectable		 2coiA-2qvkA:
19.43
2coiB-2qvkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2qvk SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 11 THR A 541
GLY A 544
THR A 586
ALA A 546
VAL A 573
 None
 1.17A 2cojA-2qvkA:
undetectable
2cojB-2qvkA:
undetectable		 2cojA-2qvkA:
19.43
2cojB-2qvkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2qvk SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 9 VAL A 573
THR A 541
GLY A 544
THR A 586
ALA A 546
 None
 1.12A 2cojA-2qvkA:
undetectable
2cojB-2qvkA:
undetectable		 2cojA-2qvkA:
19.43
2cojB-2qvkA:
19.43