SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 6 LEU A 193
LEU A 170
PRO A 171
MET A 169
 None
 1.20A 1hz4A-2qvlA:
undetectable		 1hz4A-2qvlA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		5 / 12 PHE A 133
LEU A 268
ALA A 137
PHE A 194
LEU A 285
 None
 1.06A 1kglA-2qvlA:
undetectable		 1kglA-2qvlA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 7 ASP A 290
GLY A  88
ILE A  63
ILE A  78
 None
 0.77A 1n49A-2qvlA:
undetectable		 1n49A-2qvlA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 6 ASP A 290
GLY A  88
ILE A  63
ILE A  78
 None
 0.77A 1n49D-2qvlA:
undetectable		 1n49D-2qvlA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		5 / 12 THR A  41
GLY A  67
GLY A  69
VAL A  95
ASN A  10
 None
 1.07A 1nv8A-2qvlA:
2.3		 1nv8A-2qvlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		5 / 12 ALA A 280
LEU A 268
LEU A 266
ILE A 223
LEU A 196
 None
 0.92A 1qknA-2qvlA:
undetectable		 1qknA-2qvlA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		3 / 3 ASP A  60
TYR A  59
GLU A  35
 None
 0.84A 1vm1A-2qvlA:
undetectable		 1vm1A-2qvlA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		3 / 3 GLY A 275
ARG A 131
TYR A 274
 None
 0.85A 2opxA-2qvlA:
4.1		 2opxA-2qvlA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		3 / 3 ASN A 304
LEU A 302
HIS A 307
 None
 0.75A 2q6fB-2qvlA:
undetectable		 2q6fB-2qvlA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 6 LEU A 221
TYR A 182
ILE A 260
ILE A 223
 None
 0.82A 2q8hA-2qvlA:
undetectable		 2q8hA-2qvlA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 7 LEU A 178
SER A 262
THR A 264
VAL A 176
 None
 1.07A 2uz2A-2qvlA:
undetectable		 2uz2A-2qvlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		5 / 10 ASP A 290
GLY A  88
ILE A  63
ALA A  51
ILE A  78
 None
 0.99A 3ekwA-2qvlA:
undetectable		 3ekwA-2qvlA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		5 / 12 ALA A 280
LEU A 268
LEU A 266
ILE A 223
LEU A 196
 None
 1.09A 3olsB-2qvlA:
undetectable		 3olsB-2qvlA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 5 ASN A  96
PRO A  91
GLY A  67
ASP A  24
 None
 0.89A 4n48B-2qvlA:
undetectable		 4n48B-2qvlA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 8 TYR A 182
ILE A 251
LYS A 249
ILE A 223
 None
 0.96A 4ou1A-2qvlA:
undetectable		 4ou1A-2qvlA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 7 ILE A 125
LEU A  71
LEU A  87
ILE A  78
 None
 0.86A 4rmjA-2qvlA:
2.7		 4rmjA-2qvlA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 4 LEU A 193
ILE A 223
GLY A 139
ILE A 180
 None
 0.60A 5dzk3-2qvlA:
undetectable
5dzkm-2qvlA:
undetectable		 5dzk3-2qvlA:
0.93
5dzkm-2qvlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 5 ILE A 223
GLY A 139
ILE A 180
LEU A 193
 None
 0.58A 5dzkB-2qvlA:
undetectable
5dzkI-2qvlA:
undetectable
5dzkW-2qvlA:
undetectable		 5dzkB-2qvlA:
21.53
5dzkI-2qvlA:
21.41
5dzkW-2qvlA:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 5 ILE A 223
GLY A 139
ILE A 180
LEU A 193
 None
 0.65A 5dzki-2qvlA:
undetectable
5dzkj-2qvlA:
undetectable
5dzkx-2qvlA:
undetectable		 5dzki-2qvlA:
21.41
5dzkj-2qvlA:
21.41
5dzkx-2qvlA:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 5 ILE A 223
GLY A 139
ILE A 180
LEU A 193
 None
 0.65A 5dzkd-2qvlA:
undetectable
5dzkk-2qvlA:
undetectable
5dzky-2qvlA:
undetectable		 5dzkd-2qvlA:
21.53
5dzkk-2qvlA:
21.41
5dzky-2qvlA:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		4 / 4 ILE A 223
GLY A 139
ILE A 180
LEU A 193
 None
 0.65A 5dzkl-2qvlA:
undetectable
5dzkz-2qvlA:
undetectable		 5dzkl-2qvlA:
21.41
5dzkz-2qvlA:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		5 / 12 PHE A 133
LEU A 268
ALA A 137
PHE A 194
LEU A 285
 None
 0.97A 5ljbA-2qvlA:
undetectable		 5ljbA-2qvlA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		6 / 12 PHE A 133
LEU A 268
ALA A 137
LEU A 196
PHE A 194
LEU A 285
 None
 1.19A 5ljcA-2qvlA:
undetectable		 5ljcA-2qvlA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		5 / 12 PHE A 133
LEU A 268
ALA A 137
PHE A 194
LEU A 285
 None
 0.95A 5ljeA-2qvlA:
undetectable		 5ljeA-2qvlA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		3 / 3 TYR A 274
ALA A 280
LEU A 278
 None
 0.70A 6ag0C-2qvlA:
undetectable		 6ag0C-2qvlA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2qvl DIACYLGLYCEROL
KINASE DGKB
(Staphylococcus
aureus) 		3 / 3 ASP A 183
ASP A 124
ASN A 299
 None
 0.86A 6gngB-2qvlA:
4.5		 6gngB-2qvlA:
22.33