SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E7C_A_HLTA4007_1 (SERUM ALBUMIN)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	4 / 8	ASN B 240 ASP B 140 LEU B 144 LEU B 139	ASN B 240 ( 0.6A) ASP B 140 ( 0.5A) LEU B 144 ( 0.6A) LEU B 139 ( 0.6A)	1.00A	1e7cA-2qvsB: undetectable	1e7cA-2qvsB: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EIZ_A_SAMA301_1 (FTSJ)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	3 / 3	ASP B 181 ASP B 197 ASP B 159	ASP B 181 ( 0.5A) ASP B 197 ( 0.6A) ASP B 159 ( 0.5A)	0.71A	1eizA-2qvsB: undetectable	1eizA-2qvsB: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EJ0_A_SAMA301_1 (FTSJ)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	3 / 3	ASP B 181 ASP B 197 ASP B 159	ASP B 181 ( 0.5A) ASP B 197 ( 0.6A) ASP B 159 ( 0.5A)	0.70A	1ej0A-2qvsB: undetectable	1ej0A-2qvsB: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P2Y_A_NCTA440_1 (CYTOCHROME P450-CAM)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	4 / 7	LEU B 225 VAL B 156 GLY B 223 ILE B 218	LEU B 225 ( 0.6A) VAL B 156 ( 0.6A) GLY B 223 ( 0.0A) ILE B 218 ( 0.7A)	0.81A	1p2yA-2qvsB: undetectable	1p2yA-2qvsB: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PK7_B_ADNB1246_1 (PURINE NUCLEOSIDE PHOSPHORYLASE)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	4 / 8	GLY B 349 VAL B 302 GLU B 301 ILE B 284	GLY B 349 ( 0.0A) VAL B 302 ( 0.6A) GLU B 301 ( 0.6A) ILE B 284 ( 0.7A)	0.76A	1pk7B-2qvsB: undetectable	1pk7B-2qvsB: 22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGN_A_ACTA1181_0 (WNT INHIBITORY FACTOR 1)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	3 / 3	TYR B 180 VAL B 156 THR B 179	TYR B 180 ( 1.3A) VAL B 156 ( 0.6A) THR B 179 ( 0.8A)	0.80A	2ygnA-2qvsB: undetectable	2ygnA-2qvsB: 18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_1 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	3 / 3	ASP B 181 ASP B 197 ASP B 159	ASP B 181 ( 0.5A) ASP B 197 ( 0.6A) ASP B 159 ( 0.5A)	0.70A	3douA-2qvsB: undetectable	3douA-2qvsB: 21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N0H_A_TOPA187_1 (DIHYDROFOLATE REDUCTASE)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	5 / 11	ILE B 163 ALA B 215 PHE B 202 LEU B 225 VAL B 162	ILE B 163 ( 0.7A) ALA B 215 ( 0.0A) PHE B 202 ( 1.3A) LEU B 225 ( 0.6A) VAL B 162 ( 0.6A)	1.15A	3n0hA-2qvsB: undetectable	3n0hA-2qvsB: 18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3V_A_TOPA187_1 (DIHYDROFOLATE REDUCTASE)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	5 / 12	ILE B 163 ALA B 215 PHE B 202 LEU B 225 VAL B 162	ILE B 163 ( 0.7A) ALA B 215 ( 0.0A) PHE B 202 ( 1.3A) LEU B 225 ( 0.6A) VAL B 162 ( 0.6A)	1.14A	3s3vA-2qvsB: undetectable	3s3vA-2qvsB: 18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TKA_A_SAMA400_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE H)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	5 / 12	GLY B 349 GLY B 300 ARG B 283 SER B 303 GLU B 289	GLY B 349 ( 0.0A) GLY B 300 ( 0.0A) ARG B 283 ( 0.6A) SER B 303 ( 0.0A) GLU B 289 ( 0.6A)	1.38A	3tkaA-2qvsB: undetectable	3tkaA-2qvsB: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6M_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2qvs	CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT (Mus musculus)	5 / 11	ASP B 229 LEU B 228 PHE B 233 LEU B 139 ILE B 237	ASP B 229 ( 0.5A) LEU B 228 ( 0.6A) PHE B 233 ( 1.3A) LEU B 139 ( 0.6A) ILE B 237 ( 0.6A)	1.07A	5z6mA-2qvsB: undetectable	5z6mA-2qvsB: 18.06

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E7C_A_HLTA4007_1","SERUM ALBUMIN","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",4,"ASN B 240;ASP B 140;LEU B 144;LEU B 139","ASN B 240 ( 0.6A);ASP B 140 ( 0.5A);LEU B 144 ( 0.6A);LEU B 139 ( 0.6A)","1.00A","1e7cA-2qvsB:undetectable","1e7cA-2qvsB:18.57"],["1EIZ_A_SAMA301_1","FTSJ","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",3,"ASP B 181;ASP B 197;ASP B 159","ASP B 181 ( 0.5A);ASP B 197 ( 0.6A);ASP B 159 ( 0.5A)","0.71A","1eizA-2qvsB:undetectable","1eizA-2qvsB:22.22"],["1EJ0_A_SAMA301_1","FTSJ","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",3,"ASP B 181;ASP B 197;ASP B 159","ASP B 181 ( 0.5A);ASP B 197 ( 0.6A);ASP B 159 ( 0.5A)","0.70A","1ej0A-2qvsB:undetectable","1ej0A-2qvsB:22.22"],["1P2Y_A_NCTA440_1","CYTOCHROME P450-CAM","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",4,"LEU B 225;VAL B 156;GLY B 223;ILE B 218","LEU B 225 ( 0.6A);VAL B 156 ( 0.6A);GLY B 223 ( 0.0A);ILE B 218 ( 0.7A)","0.81A","1p2yA-2qvsB:undetectable","1p2yA-2qvsB:19.73"],["1PK7_B_ADNB1246_1","PURINE NUCLEOSIDE PHOSPHORYLASE","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",4,"GLY B 349;VAL B 302;GLU B 301;ILE B 284","GLY B 349 ( 0.0A);VAL B 302 ( 0.6A);GLU B 301 ( 0.6A);ILE B 284 ( 0.7A)","0.76A","1pk7B-2qvsB:undetectable","1pk7B-2qvsB:22.70"],["2YGN_A_ACTA1181_0","WNT INHIBITORY FACTOR 1","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",3,"TYR B 180;VAL B 156;THR B 179","TYR B 180 ( 1.3A);VAL B 156 ( 0.6A);THR B 179 ( 0.8A)","0.80A","2ygnA-2qvsB:undetectable","2ygnA-2qvsB:18.21"],["3DOU_A_SAMA1_1","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",3,"ASP B 181;ASP B 197;ASP B 159","ASP B 181 ( 0.5A);ASP B 197 ( 0.6A);ASP B 159 ( 0.5A)","0.70A","3douA-2qvsB:undetectable","3douA-2qvsB:21.50"],["3N0H_A_TOPA187_1","DIHYDROFOLATE REDUCTASE","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",5,"ILE B 163;ALA B 215;PHE B 202;LEU B 225;VAL B 162","ILE B 163 ( 0.7A);ALA B 215 ( 0.0A);PHE B 202 ( 1.3A);LEU B 225 ( 0.6A);VAL B 162 ( 0.6A)","1.15A","3n0hA-2qvsB:undetectable","3n0hA-2qvsB:18.50"],["3S3V_A_TOPA187_1","DIHYDROFOLATE REDUCTASE","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",5,"ILE B 163;ALA B 215;PHE B 202;LEU B 225;VAL B 162","ILE B 163 ( 0.7A);ALA B 215 ( 0.0A);PHE B 202 ( 1.3A);LEU B 225 ( 0.6A);VAL B 162 ( 0.6A)","1.14A","3s3vA-2qvsB:undetectable","3s3vA-2qvsB:18.50"],["3TKA_A_SAMA400_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE H","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",5,"GLY B 349;GLY B 300;ARG B 283;SER B 303;GLU B 289","GLY B 349 ( 0.0A);GLY B 300 ( 0.0A);ARG B 283 ( 0.6A);SER B 303 ( 0.0A);GLU B 289 ( 0.6A)","1.38A","3tkaA-2qvsB:undetectable","3tkaA-2qvsB:21.95"],["5Z6M_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2qvs","CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT","Mus musculus",5,"ASP B 229;LEU B 228;PHE B 233;LEU B 139;ILE B 237","ASP B 229 ( 0.5A);LEU B 228 ( 0.6A);PHE B 233 ( 1.3A);LEU B 139 ( 0.6A);ILE B 237 ( 0.6A)","1.07A","5z6mA-2qvsB:undetectable","5z6mA-2qvsB:18.06"]]