SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 6 ALA A 358
TRP A 538
ARG A 350
LEU A 363
 MN  A 765 ( 4.8A)
None
None
None
 1.21A 1gahA-2qvwA:
undetectable		 1gahA-2qvwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 6 PRO A 542
ASP A 500
ASP A 503
TRP A 504
 None
 1.43A 1hpkA-2qvwA:
undetectable		 1hpkA-2qvwA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		3 / 3 LEU A 539
LEU A 537
MET A 432
 None
 0.80A 1ya3B-2qvwA:
undetectable		 1ya3B-2qvwA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		3 / 3 ARG A 569
VAL A 588
GLY A 508
 None
 0.64A 2avvE-2qvwA:
undetectable		 2avvE-2qvwA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 6 LEU A 517
ALA A 428
HIS A 532
ASP A 528
 None
 1.23A 2dpzA-2qvwA:
undetectable		 2dpzA-2qvwA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		3 / 3 THR A 161
PRO A 243
TYR A 197
 None
 0.92A 2dxrA-2qvwA:
undetectable		 2dxrA-2qvwA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 12 GLY A 422
ILE A 566
VAL A 571
PRO A 574
VAL A 575
 None
 0.88A 2f8gB-2qvwA:
undetectable		 2f8gB-2qvwA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 5 ILE A 629
PRO A 630
PHE A 631
ILE A 729
 None
 0.95A 2hjhA-2qvwA:
undetectable		 2hjhA-2qvwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 4 LEU A 640
THR A 641
ILE A 611
HIS A 610
 None
 1.03A 2jfaB-2qvwA:
undetectable		 2jfaB-2qvwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 8 LEU A 363
ARG A 350
VAL A 563
GLY A 543
 None
 0.94A 2qd5A-2qvwA:
undetectable		 2qd5A-2qvwA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 12 ILE A 272
PHE A  48
SER A  17
LEU A 262
ILE A 268
 None
 1.29A 2xkwB-2qvwA:
undetectable		 2xkwB-2qvwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 5 TYR A 406
ILE A 409
LEU A 385
LEU A 383
 None
 1.07A 2zb7A-2qvwA:
undetectable		 2zb7A-2qvwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		3 / 3 GLY A 309
ASP A 307
SER A 392
 None
 0.68A 3brfA-2qvwA:
undetectable		 3brfA-2qvwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 12 TYR A 577
GLY A 508
GLY A 536
ASP A 528
SER A 512
 None
 1.19A 3dlcA-2qvwA:
undetectable		 3dlcA-2qvwA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 12 ILE A 725
ALA A 727
LEU A 648
VAL A 700
LEU A 620
 None
 0.96A 3dzuA-2qvwA:
undetectable		 3dzuA-2qvwA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 8 PHE A 480
SER A 482
LEU A 370
PHE A 355
LEU A 351
 None
 1.43A 3i45A-2qvwA:
undetectable		 3i45A-2qvwA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 6 CYH A   8
GLU A  49
PHE A  33
PHE A 321
 None
 1.28A 3m0wB-2qvwA:
undetectable
3m0wJ-2qvwA:
undetectable		 3m0wB-2qvwA:
8.65
3m0wJ-2qvwA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 6 PHE A 112
ILE A 268
ALA A 269
ALA A 108
 None
 0.90A 3mdrB-2qvwA:
undetectable		 3mdrB-2qvwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 12 SER A 707
ALA A 612
ILE A 725
ALA A 724
GLY A 690
 None
 1.06A 3nxuA-2qvwA:
undetectable		 3nxuA-2qvwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 8 ALA A 613
VAL A 616
LEU A 620
LEU A 635
 None
 0.81A 3roxA-2qvwA:
undetectable		 3roxA-2qvwA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 5 PHE A 264
ALA A 261
THR A  12
LEU A 218
 None
 1.18A 3t3zC-2qvwA:
undetectable		 3t3zC-2qvwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 7 ILE A 346
GLU A 424
PHE A 414
HIS A 568
 None
 0.86A 4a97D-2qvwA:
undetectable		 4a97D-2qvwA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 8 ILE A 529
ASP A 528
SER A 541
GLY A 536
 None
 0.81A 4ac9C-2qvwA:
2.5		 4ac9C-2qvwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 8 ILE A 529
ASP A 528
SER A 541
GLY A 536
 None
 0.83A 4acbC-2qvwA:
undetectable		 4acbC-2qvwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 5 HIS A 568
GLY A 734
TYR A 567
TYR A 565
 None
 1.47A 4ae1B-2qvwA:
undetectable		 4ae1B-2qvwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 12 ILE A 413
ALA A 428
PHE A 426
LEU A 383
ILE A 409
 None
 0.94A 4kjjA-2qvwA:
undetectable		 4kjjA-2qvwA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 7 ALA A 111
LEU A 115
ASP A  60
LEU A  56
 None
 0.83A 4l9iA-2qvwA:
undetectable		 4l9iA-2qvwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		3 / 3 LEU A 427
ARG A 535
MET A 530
 None
 0.97A 4m11C-2qvwA:
3.1		 4m11C-2qvwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 12 LEU A 620
LEU A 632
ILE A 633
ILE A 611
PRO A 697
 None
 0.95A 4odrA-2qvwA:
2.3
4odrB-2qvwA:
2.3		 4odrA-2qvwA:
10.20
4odrB-2qvwA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 12 VAL A 159
CYH A 247
VAL A 171
LEU A 154
ARG A 157
 None
 1.26A 4po0A-2qvwA:
3.7		 4po0A-2qvwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 8 ILE A 729
LEU A 662
LEU A 656
PHE A 741
 None
None
MN  A 757 ( 4.7A)
None
 0.97A 4r38B-2qvwA:
undetectable		 4r38B-2qvwA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 8 MET A 530
LEU A 533
LEU A 354
LEU A 490
 None
 1.24A 5dxeA-2qvwA:
undetectable		 5dxeA-2qvwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 12 ALA A 341
LEU A 337
ALA A 661
LEU A 664
ALA A 654
 None
 1.11A 5jglB-2qvwA:
undetectable		 5jglB-2qvwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 6 PHE A 298
LEU A  30
ARG A 296
GLY A 293
 None
 1.04A 5o4yF-2qvwA:
undetectable		 5o4yF-2qvwA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 6 GLY A 586
ASP A 503
GLY A 578
PRO A 574
 None
 0.61A 6ag0C-2qvwA:
undetectable		 6ag0C-2qvwA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 10 ALA A 315
ASP A 274
PHE A  33
VAL A  35
THR A  96
 None
 1.44A 6aogA-2qvwA:
undetectable		 6aogA-2qvwA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		5 / 10 ALA A 315
ASP A 274
PHE A  33
VAL A  35
THR A  96
 None
 1.47A 6aogB-2qvwA:
undetectable		 6aogB-2qvwA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2qvw GLP_546_48378_50642
(Giardia
intestinalis) 		4 / 8 MET A 530
LEU A 533
LEU A 354
LEU A 490
 None
 1.25A 6cbzA-2qvwA:
undetectable		 6cbzA-2qvwA:
7.57