SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		5 / 9 GLY A 127
TYR A 133
ILE A 184
GLU A 188
ARG A 252
 XLS  A 401 ( 4.7A)
XLS  A 401 ( 3.8A)
XLS  A 401 ( 4.3A)
XLS  A 401 (-3.2A)
XLS  A 401 ( 4.0A)
 1.01A 1mrgA-2qw5A:
undetectable		 1mrgA-2qw5A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		5 / 12 ILE A 184
GLU A 280
LEU A 292
PHE A 288
GLU A 188
 XLS  A 401 ( 4.3A)
ZN  A 400 (-2.5A)
None
None
XLS  A 401 (-3.2A)
 1.33A 2no0A-2qw5A:
undetectable		 2no0A-2qw5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		5 / 12 ILE A 184
GLU A 280
LEU A 292
PHE A 288
GLU A 188
 XLS  A 401 ( 4.3A)
ZN  A 400 (-2.5A)
None
None
XLS  A 401 (-3.2A)
 1.32A 2no0B-2qw5A:
undetectable		 2no0B-2qw5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 8 LEU A  39
ILE A  31
TYR A  28
PHE A  17
 None
 0.88A 2weyB-2qw5A:
undetectable		 2weyB-2qw5A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		5 / 12 PHE A  93
GLY A  88
ILE A 184
ASP A 215
PHE A 282
 None
XLS  A 401 ( 4.7A)
XLS  A 401 ( 4.3A)
ZN  A 400 (-3.3A)
XLS  A 401 (-4.6A)
 1.45A 2zznB-2qw5A:
undetectable		 2zznB-2qw5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		3 / 3 PRO A 261
LEU A 260
ARG A 252
 None
None
XLS  A 401 ( 4.0A)
 0.83A 3aqiB-2qw5A:
undetectable		 3aqiB-2qw5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 5 PRO A 192
ILE A 131
PRO A 190
TYR A 133
 None
None
None
XLS  A 401 ( 3.8A)
 1.29A 3d9lA-2qw5A:
undetectable
3d9lY-2qw5A:
undetectable		 3d9lA-2qw5A:
16.27
3d9lY-2qw5A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		3 / 3 SER A 248
ASP A 215
ASP A 251
 None
ZN  A 400 (-3.3A)
None
 0.88A 3iv6A-2qw5A:
undetectable		 3iv6A-2qw5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 8 TYR A 244
PRO A  50
SER A  13
ASP A 215
 None
None
None
ZN  A 400 (-3.3A)
 1.12A 3lsfH-2qw5A:
undetectable		 3lsfH-2qw5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 5 LEU A 294
PHE A 288
PRO A 286
ALA A 287
 None
None
CL  A 402 ( 3.9A)
CL  A 402 (-3.5A)
 1.41A 3vm4A-2qw5A:
undetectable		 3vm4A-2qw5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 7 GLU A 105
GLU A 108
TYR A 109
ARG A 113
 None
 0.82A 4fgzA-2qw5A:
undetectable		 4fgzA-2qw5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 8 GLU A 105
GLU A 108
TYR A 109
ARG A 113
 None
 0.89A 4fgzA-2qw5A:
undetectable
4fgzB-2qw5A:
undetectable		 4fgzA-2qw5A:
22.12
4fgzB-2qw5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 7 TYR A 109
ILE A 131
LEU A 168
LEU A 165
 None
 1.03A 4l1wA-2qw5A:
9.1		 4l1wA-2qw5A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		3 / 3 HIS A 218
VAL A 233
LEU A 195
 XLS  A 401 (-4.3A)
None
None
 0.68A 4m2vA-2qw5A:
undetectable		 4m2vA-2qw5A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		3 / 3 SER A  84
MET A 126
ASP A 274
 None
 0.96A 4mm4B-2qw5A:
undetectable		 4mm4B-2qw5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 8 THR A  85
GLY A 122
GLY A 121
ASP A  74
 None
 0.84A 4qvvK-2qw5A:
undetectable
4qvvL-2qw5A:
undetectable		 4qvvK-2qw5A:
20.06
4qvvL-2qw5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 7 TYR A 109
ILE A 131
LEU A 168
LEU A 165
 None
 0.97A 4xo7A-2qw5A:
9.1		 4xo7A-2qw5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		5 / 9 GLY A 127
TYR A 133
ILE A 184
GLU A 188
ARG A 252
 XLS  A 401 ( 4.7A)
XLS  A 401 ( 3.8A)
XLS  A 401 ( 4.3A)
XLS  A 401 (-3.2A)
XLS  A 401 ( 4.0A)
 1.01A 4yp2B-2qw5A:
undetectable		 4yp2B-2qw5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		5 / 12 LEU A 328
VAL A 270
ILE A 269
LEU A 255
LEU A 260
 None
 1.31A 4yvpB-2qw5A:
8.8		 4yvpB-2qw5A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		5 / 9 GLY A 127
TYR A 133
ILE A 184
GLU A 188
ARG A 252
 XLS  A 401 ( 4.7A)
XLS  A 401 ( 3.8A)
XLS  A 401 ( 4.3A)
XLS  A 401 (-3.2A)
XLS  A 401 ( 4.0A)
 1.01A 5cf9B-2qw5A:
undetectable		 5cf9B-2qw5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 5 ALA A 278
GLU A  48
ASN A  86
GLU A 182
 None
None
XLS  A 401 (-3.2A)
ZN  A 400 ( 2.7A)
 1.48A 5dwkC-2qw5A:
undetectable		 5dwkC-2qw5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		5 / 12 PHE A 265
GLU A 219
PRO A 268
SER A   8
GLY A 275
 None
 1.35A 5xioA-2qw5A:
undetectable		 5xioA-2qw5A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		4 / 8 GLU A 280
HIS A 218
PHE A 136
LEU A 150
 ZN  A 400 (-2.5A)
XLS  A 401 (-4.3A)
None
None
 0.97A 5y2tB-2qw5A:
undetectable		 5y2tB-2qw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL
(Trichormus
variabilis) 		3 / 3 LEU A 266
SER A 264
PHE A 265
 None
 0.63A 6fgcA-2qw5A:
undetectable		 6fgcA-2qw5A:
22.10