SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qw8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 8 LEU A 265
ALA A 180
ILE A 216
PHE A 158
 None
None
None
NAP  A 401 (-4.4A)
 0.78A 1d4sB-2qw8A:
undetectable		 1d4sB-2qw8A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1870_0
(FPRA)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 4 HIS A  32
PRO A  33
LYS A   9
ILE A  10
 None
 1.34A 1lqtA-2qw8A:
6.6		 1lqtA-2qw8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 11 SER A 284
LEU A 286
THR A 285
THR A 147
VAL A 149
 None
 1.12A 1pkvA-2qw8A:
undetectable
1pkvB-2qw8A:
undetectable		 1pkvA-2qw8A:
17.26
1pkvB-2qw8A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 11 VAL A 149
SER A 284
LEU A 286
THR A 285
THR A 147
 None
 1.12A 1pkvA-2qw8A:
undetectable
1pkvB-2qw8A:
undetectable		 1pkvA-2qw8A:
17.26
1pkvB-2qw8A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 5 PHE A 125
LEU A 265
PHE A  85
SER A 311
 NO3  A 902 (-4.9A)
None
NAP  A 401 ( 3.5A)
None
 1.37A 1wrkB-2qw8A:
undetectable		 1wrkB-2qw8A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 PHE A 112
TYR A 210
ASN A 152
VAL A 208
 None
 0.93A 1wu8A-2qw8A:
1.9
1wu8C-2qw8A:
1.3		 1wu8A-2qw8A:
22.05
1wu8C-2qw8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		3 / 3 PHE A 314
TYR A 157
TYR A 161
 PEG  A 901 (-4.8A)
NAP  A 401 (-4.5A)
None
 0.91A 1x70B-2qw8A:
3.7		 1x70B-2qw8A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 8 GLY A  14
GLY A  15
GLY A  20
ALA A  82
ILE A  10
 NAP  A 401 ( 3.7A)
None
None
NAP  A 401 (-4.8A)
None
 0.93A 1yajC-2qw8A:
undetectable		 1yajC-2qw8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 11 SER A  81
VAL A  79
ILE A  98
LEU A  63
LEU A  69
 None
 1.24A 2a15A-2qw8A:
undetectable		 2a15A-2qw8A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 12 GLU A 130
SER A  81
GLN A  91
TYR A 148
GLU A 140
 None
 1.38A 2aouB-2qw8A:
2.5		 2aouB-2qw8A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 12 TYR A 210
SER A 150
ALA A 121
ALA A 270
ASP A 268
 None
 1.25A 2avdA-2qw8A:
7.3		 2avdA-2qw8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		3 / 3 ARG A 136
VAL A 197
GLY A 191
 None
 0.59A 2avvE-2qw8A:
undetectable		 2avvE-2qw8A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 5 PRO A  86
ILE A  88
ARG A 131
ASP A  90
 None
 1.27A 2rhmB-2qw8A:
undetectable		 2rhmB-2qw8A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 12 LEU A  54
THR A  16
GLY A  15
GLY A  20
LEU A  28
 None
NAP  A 401 (-2.8A)
None
None
None
 1.21A 2uvnA-2qw8A:
undetectable		 2uvnA-2qw8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 10 THR A 147
ILE A  80
LEU A  11
VAL A  76
ARG A 106
 None
 1.14A 2wd9C-2qw8A:
2.3		 2wd9C-2qw8A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 9 ARG A 106
LEU A 108
GLY A  26
VAL A  78
ILE A  80
 None
 1.16A 3d1yB-2qw8A:
undetectable		 3d1yB-2qw8A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 PHE A 276
GLU A 115
SER A 150
VAL A 207
 None
 1.39A 3dqtA-2qw8A:
undetectable
3dqtB-2qw8A:
undetectable		 3dqtA-2qw8A:
22.38
3dqtB-2qw8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 8 ILE A  19
TYR A 210
ASN A 215
GLY A 113
 NAP  A 401 (-4.4A)
None
None
NO3  A 902 ( 3.3A)
 0.77A 3em0B-2qw8A:
undetectable		 3em0B-2qw8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		6 / 12 ARG A 106
LEU A 108
GLY A  26
LEU A  30
VAL A  78
ILE A  80
 None
 1.41A 3em6B-2qw8A:
undetectable		 3em6B-2qw8A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 SER A 150
VAL A 207
PHE A 276
GLU A 115
 None
 1.37A 3n5tA-2qw8A:
undetectable
3n5tB-2qw8A:
undetectable		 3n5tA-2qw8A:
21.66
3n5tB-2qw8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		3 / 3 ASN A 103
ALA A 101
LYS A  74
 None
 1.03A 3runA-2qw8A:
undetectable		 3runA-2qw8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 8 VAL A 174
TYR A 175
ILE A 172
ILE A 237
 None
 1.03A 4afgD-2qw8A:
undetectable
4afgE-2qw8A:
undetectable		 4afgD-2qw8A:
18.57
4afgE-2qw8A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 PHE A 276
GLU A 115
SER A 150
VAL A 207
 None
 1.38A 4k5jA-2qw8A:
undetectable
4k5jB-2qw8A:
undetectable		 4k5jA-2qw8A:
21.71
4k5jB-2qw8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		6 / 12 ARG A 106
LEU A 108
ILE A  12
GLY A  26
VAL A  78
ILE A  80
 None
 1.16A 4q1xB-2qw8A:
undetectable		 4q1xB-2qw8A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 11 GLY A  15
GLY A  14
GLY A  26
ILE A  80
PHE A 112
 None
NAP  A 401 ( 3.7A)
None
None
None
 0.97A 4qoiA-2qw8A:
7.5
4qoiB-2qw8A:
8.0		 4qoiA-2qw8A:
22.53
4qoiB-2qw8A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		3 / 3 ARG A 137
TYR A 146
GLU A 140
 None
 0.59A 4zzbE-2qw8A:
undetectable		 4zzbE-2qw8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 PHE A 276
GLU A 115
SER A 150
VAL A 207
 None
 1.39A 5adlA-2qw8A:
undetectable
5adlB-2qw8A:
undetectable		 5adlA-2qw8A:
21.71
5adlB-2qw8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		3 / 3 PHE A 276
ILE A 209
ASP A 117
 None
 0.75A 5cswA-2qw8A:
undetectable		 5cswA-2qw8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 PHE A 276
GLU A 115
SER A 150
VAL A 207
 None
 1.39A 5fj3A-2qw8A:
undetectable
5fj3B-2qw8A:
undetectable		 5fj3A-2qw8A:
21.71
5fj3B-2qw8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 6 ILE A  58
VAL A  24
TYR A  35
VAL A  36
 None
 0.95A 5jwaH-2qw8A:
6.2		 5jwaH-2qw8A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 8 ILE A  98
ILE A 135
ALA A 138
ILE A 139
 None
 0.71A 5mvmA-2qw8A:
undetectable
5mvmB-2qw8A:
undetectable		 5mvmA-2qw8A:
15.03
5mvmB-2qw8A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 8 ILE A 129
ILE A 257
ALA A 260
ILE A 261
 None
None
None
PEG  A 901 (-3.8A)
 0.50A 5mvmA-2qw8A:
undetectable
5mvmB-2qw8A:
undetectable		 5mvmA-2qw8A:
15.03
5mvmB-2qw8A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 12 PHE A 158
PHE A 314
ALA A 313
ALA A 310
GLU A 187
 NAP  A 401 (-4.4A)
PEG  A 901 (-4.8A)
NAP  A 401 ( 4.1A)
None
None
 1.20A 5vcgA-2qw8A:
undetectable		 5vcgA-2qw8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		5 / 12 PHE A 266
PHE A 125
PHE A 314
ALA A 313
ALA A 310
 None
NO3  A 902 (-4.9A)
PEG  A 901 (-4.8A)
NAP  A 401 ( 4.1A)
None
 1.03A 5veuA-2qw8A:
undetectable		 5veuA-2qw8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 PHE A 276
GLU A 115
SER A 150
VAL A 207
 None
 1.38A 5vv7A-2qw8A:
undetectable
5vv7B-2qw8A:
undetectable		 5vv7A-2qw8A:
21.71
5vv7B-2qw8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 SER A 150
VAL A 207
PHE A 276
GLU A 115
 None
 1.36A 6av6A-2qw8A:
undetectable
6av6B-2qw8A:
undetectable		 6av6A-2qw8A:
11.90
6av6B-2qw8A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 PHE A 276
GLU A 115
SER A 150
VAL A 207
 None
 1.37A 6av6C-2qw8A:
undetectable
6av6D-2qw8A:
undetectable		 6av6C-2qw8A:
11.90
6av6D-2qw8A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 7 SER A 150
VAL A 207
PHE A 276
GLU A 115
 None
 1.39A 6av7A-2qw8A:
undetectable
6av7B-2qw8A:
undetectable		 6av7A-2qw8A:
11.90
6av7B-2qw8A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		4 / 4 PHE A  13
ASP A  90
LEU A  69
LYS A  93
 None
 1.41A 6awvA-2qw8A:
undetectable		 6awvA-2qw8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2qw8 EUGENOL SYNTHASE 1
(Ocimum
basilicum) 		3 / 3 ILE A 301
ASN A 215
CYH A 153
 None
 0.89A 6bp4A-2qw8A:
undetectable		 6bp4A-2qw8A:
21.05