SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		4 / 7 PHE A  89
MET A  93
VAL A  94
SER A  96
 None
 0.57A 1wrlA-2qwtA:
undetectable
1wrlB-2qwtA:
undetectable		 1wrlA-2qwtA:
16.41
1wrlB-2qwtA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		4 / 7 VAL A  47
ILE A  36
ALA A  40
VAL A  42
 None
 0.64A 2xrzB-2qwtA:
undetectable		 2xrzB-2qwtA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		5 / 12 LEU A 129
GLY A 130
LEU A 132
ALA A 136
LEU A 180
 None
 0.93A 3gwvA-2qwtA:
undetectable		 3gwvA-2qwtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		5 / 12 VAL A  47
LEU A  57
ALA A  10
GLY A  41
ALA A  40
 None
 0.91A 3ln1A-2qwtA:
undetectable		 3ln1A-2qwtA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		5 / 12 VAL A  47
LEU A  57
ALA A  10
GLY A  41
ALA A  40
 None
 0.91A 3ln1B-2qwtA:
undetectable		 3ln1B-2qwtA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		5 / 12 VAL A  47
LEU A  57
ALA A  10
GLY A  41
ALA A  40
 None
 0.91A 3ln1C-2qwtA:
2.0		 3ln1C-2qwtA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		5 / 12 VAL A  47
LEU A  57
ALA A  10
GLY A  41
ALA A  40
 None
 0.91A 3ln1D-2qwtA:
undetectable		 3ln1D-2qwtA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		4 / 6 THR A 128
GLY A 130
ILE A 151
LEU A 126
 None
 1.06A 4acbC-2qwtA:
undetectable		 4acbC-2qwtA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		5 / 8 MET A  93
LEU A 154
LEU A 129
ILE A 176
VAL A 142
 None
 1.47A 4klaA-2qwtA:
undetectable		 4klaA-2qwtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
vanbaalenii) 		5 / 12 VAL A  47
LEU A  57
ALA A  10
GLY A  41
ALA A  40
 None
 0.90A 5jw1A-2qwtA:
undetectable		 5jw1A-2qwtA:
17.29