SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C
(Francisella
tularensis) 		5 / 9 ALA A  67
ALA A  54
SER A  72
GLY A  92
ALA A  70
 None
 1.43A 2vh3A-2qwuA:
undetectable		 2vh3A-2qwuA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C
(Francisella
tularensis) 		4 / 6 ILE A  89
ILE A   7
LEU A  91
MET A  36
 None
 1.05A 3adsA-2qwuA:
undetectable		 3adsA-2qwuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C
(Francisella
tularensis) 		4 / 5 SER A 157
ILE A 120
GLY A 182
PRO A 150
 None
 0.86A 3uboB-2qwuA:
undetectable		 3uboB-2qwuA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C
(Francisella
tularensis) 		4 / 6 SER A  88
ASP A 181
THR A 184
ILE A  87
 None
 0.98A 4acbC-2qwuA:
undetectable		 4acbC-2qwuA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C
(Francisella
tularensis) 		4 / 7 VAL A 202
VAL A 192
MET A  76
VAL A  20
 None
 1.12A 4e1gB-2qwuA:
undetectable		 4e1gB-2qwuA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C
(Francisella
tularensis) 		3 / 3 SER A  40
ALA A  71
VAL A  93
 None
 0.68A 4o2bC-2qwuA:
undetectable		 4o2bC-2qwuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C
(Francisella
tularensis) 		5 / 10 ALA A 115
ILE A 120
ILE A 180
PHE A 156
ALA A 153
 None
 1.15A 5nukA-2qwuA:
undetectable		 5nukA-2qwuA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2qwu INTRACELLULAR GROWTH
LOCUS, SUBUNIT C
(Francisella
tularensis) 		5 / 12 LEU A 146
ILE A 120
ILE A  38
VAL A  73
LEU A 183
 None
 1.04A 6ajiA-2qwuA:
undetectable		 6ajiA-2qwuA:
12.59