SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKW_B_P1BB1475_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2qx0	7,8-DIHYDRO-6-HYDROX YMETHYLPTERIN-PYROPH OSPHOKINASE (Yersinia pestis)	4 / 6	LEU A 71 ILE A 99 ILE A 132 LEU A 34	None APC A 171 (-4.1A) CSO A 37 ( 4.6A) CSO A 37 ( 4.3A)	0.95A	2xkwB-2qx0A: undetectable	2xkwB-2qx0A: 20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M5M_A_DX4A401_0 (2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE)	2qx0	7,8-DIHYDRO-6-HYDROX YMETHYLPTERIN-PYROPH OSPHOKINASE (Yersinia pestis)	4 / 8	GLY A 9 THR A 43 ASN A 56 PHE A 124	PH2 A 181 ( 4.3A) PH2 A 181 (-3.8A) PH2 A 181 (-2.9A) PH2 A 181 (-3.4A)	0.28A	4m5mA-2qx0A: 26.3	4m5mA-2qx0A: 62.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M5M_A_DX4A401_0 (2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE)	2qx0	7,8-DIHYDRO-6-HYDROX YMETHYLPTERIN-PYROPH OSPHOKINASE (Yersinia pestis)	4 / 8	GLY A 9 THR A 43 LEU A 46 PHE A 124	PH2 A 181 ( 4.3A) PH2 A 181 (-3.8A) PH2 A 181 (-3.7A) PH2 A 181 (-3.4A)	0.74A	4m5mA-2qx0A: 26.3	4m5mA-2qx0A: 62.26

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2XKW_B_P1BB1475_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","2qx0","7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE","Yersinia pestis",4,"LEU A  71;ILE A  99;ILE A 132;LEU A  34","None;APC A 171 (-4.1A);CSO A  37 ( 4.6A);CSO A  37 ( 4.3A)","0.95A","2xkwB-2qx0A:undetectable","2xkwB-2qx0A:20.86"],["4M5M_A_DX4A401_0","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","2qx0","7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE","Yersinia pestis",4,"GLY A   9;THR A  43;ASN A  56;PHE A 124","PH2 A 181 ( 4.3A);PH2 A 181 (-3.8A);PH2 A 181 (-2.9A);PH2 A 181 (-3.4A)","0.28A","4m5mA-2qx0A:26.3","4m5mA-2qx0A:62.26"],["4M5M_A_DX4A401_0","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","2qx0","7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE","Yersinia pestis",4,"GLY A   9;THR A  43;LEU A  46;PHE A 124","PH2 A 181 ( 4.3A);PH2 A 181 (-3.8A);PH2 A 181 (-3.7A);PH2 A 181 (-3.4A)","0.74A","4m5mA-2qx0A:26.3","4m5mA-2qx0A:62.26"]]