SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2qxt LIPASE
(Bacillus
subtilis) 		4 / 6 ILE A 135
VAL A 136
ILE A  73
ILE A  87
 None
 0.85A 1uwhB-2qxtA:
undetectable		 1uwhB-2qxtA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2qxt LIPASE
(Bacillus
subtilis) 		4 / 4 GLY A  11
SER A  77
ILE A 135
HIS A 156
 None
 1.32A 1yajJ-2qxtA:
9.9		 1yajJ-2qxtA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2qxt LIPASE
(Bacillus
subtilis) 		3 / 3 ASP A  43
ASN A  51
THR A 109
 None
 0.77A 2q63B-2qxtA:
undetectable		 2q63B-2qxtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 2qxt LIPASE
(Bacillus
subtilis) 		5 / 10 GLY A 176
GLY A 172
LEU A 173
VAL A 165
ILE A 128
 None
 1.07A 3em4V-2qxtA:
undetectable		 3em4V-2qxtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2qxt LIPASE
(Bacillus
subtilis) 		4 / 7 LEU A 140
ALA A  81
GLY A  11
ILE A  12
 None
 0.84A 3spkB-2qxtA:
undetectable		 3spkB-2qxtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2qxt LIPASE
(Bacillus
subtilis) 		5 / 12 VAL A 136
HIS A 156
ASP A 133
GLY A  11
SER A  77
 None
 0.82A 3sufB-2qxtA:
undetectable		 3sufB-2qxtA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2qxt LIPASE
(Bacillus
subtilis) 		4 / 6 THR A  66
SER A  32
TYR A  37
LEU A  36
 None
 1.05A 4wozA-2qxtA:
1.5
4wozB-2qxtA:
1.4		 4wozA-2qxtA:
22.41
4wozB-2qxtA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2qxt LIPASE
(Bacillus
subtilis) 		5 / 12 LEU A 124
GLY A 172
GLY A 175
VAL A 100
ILE A 128
 None
 0.97A 6ectA-2qxtA:
undetectable		 6ectA-2qxtA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 2qxt LIPASE
(Bacillus
subtilis) 		4 / 4 MET A  78
GLY A  11
HIS A  10
GLY A  79
 None
 1.30A 6fgdA-2qxtA:
5.4		 6fgdA-2qxtA:
19.00