SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A   2
LEU A   3
ILE A  12
SER A  14
 None
 0.97A 2hc4A-2qxxA:
undetectable		 2hc4A-2qxxA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		5 / 10 GLU A  86
ILE A  32
LEU A  17
GLY A  18
PHE A  88
 None
 1.36A 2tsrC-2qxxA:
undetectable		 2tsrC-2qxxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 188
ASP A  52
ILE A  51
LEU A  60
 None
 0.96A 2ya7A-2qxxA:
undetectable		 2ya7A-2qxxA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 188
ASP A  52
ILE A  51
LEU A  60
 None
 0.97A 2ya7B-2qxxA:
undetectable		 2ya7B-2qxxA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 188
ASP A  52
ILE A  51
LEU A  60
 None
 0.95A 2ya7D-2qxxA:
undetectable		 2ya7D-2qxxA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  36
GLY A 176
GLY A  82
LEU A  39
LEU A 130
 None
 1.15A 3e23A-2qxxA:
undetectable		 3e23A-2qxxA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 125
SER A  83
THR A 127
ASP A  23
 None
None
TTP  A 201 (-4.1A)
None
 1.42A 3tm4B-2qxxA:
undetectable		 3tm4B-2qxxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 124
PHE A  88
PHE A 122
MET A 151
GLY A  18
 None
None
TTP  A 201 ( 3.7A)
None
None
 1.36A 4qa0A-2qxxA:
undetectable		 4qa0A-2qxxA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2qxx DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  36
ASP A  23
ILE A  32
 None
 0.65A 6dh0B-2qxxA:
undetectable		 6dh0B-2qxxA:
18.23