SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qya UNCHARACTERIZED
CONSERVED PROTEIN
(Methanopyrus
kandleri) 		5 / 12 ALA A  74
LEU A  19
ALA A  86
VAL A  84
ALA A  89
 None
 1.15A 1sa1A-2qyaA:
undetectable
1sa1B-2qyaA:
undetectable		 1sa1A-2qyaA:
12.64
1sa1B-2qyaA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qya UNCHARACTERIZED
CONSERVED PROTEIN
(Methanopyrus
kandleri) 		5 / 12 VAL A  70
ALA A  74
LEU A  19
VAL A  84
ALA A  89
 None
 1.05A 1sa1A-2qyaA:
undetectable
1sa1B-2qyaA:
undetectable		 1sa1A-2qyaA:
12.64
1sa1B-2qyaA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qya UNCHARACTERIZED
CONSERVED PROTEIN
(Methanopyrus
kandleri) 		5 / 12 VAL A  70
ALA A  74
LEU A  19
VAL A  84
ALA A  89
 None
 1.07A 1sa1C-2qyaA:
undetectable
1sa1D-2qyaA:
undetectable		 1sa1C-2qyaA:
12.64
1sa1D-2qyaA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 2qya UNCHARACTERIZED
CONSERVED PROTEIN
(Methanopyrus
kandleri) 		4 / 6 ALA A  18
LEU A  17
ILE A  72
CYH A  80
 None
 0.87A 1sbrA-2qyaA:
undetectable
1sbrB-2qyaA:
undetectable		 1sbrA-2qyaA:
20.00
1sbrB-2qyaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2qya UNCHARACTERIZED
CONSERVED PROTEIN
(Methanopyrus
kandleri) 		5 / 12 LEU A  75
GLY A  76
SER A  81
VAL A  82
LEU A  24
 None
 1.00A 3cjtO-2qyaA:
undetectable		 3cjtO-2qyaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2qya UNCHARACTERIZED
CONSERVED PROTEIN
(Methanopyrus
kandleri) 		5 / 12 ILE A  38
GLY A  26
TYR A  43
GLU A  96
ALA A  18
 None
 1.17A 5igvA-2qyaA:
undetectable		 5igvA-2qyaA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2qya UNCHARACTERIZED
CONSERVED PROTEIN
(Methanopyrus
kandleri) 		3 / 3 ILE A   8
ASN A  73
CYH A  80
 None
 0.82A 6bp4A-2qyaA:
undetectable		 6bp4A-2qyaA:
17.43