SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		4 / 8 LYS A 288
ALA A 254
LEU A 256
LEU A 232
 None
 0.85A 1dvtA-2qyoA:
undetectable
1dvtB-2qyoA:
undetectable		 1dvtA-2qyoA:
14.33
1dvtB-2qyoA:
14.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		6 / 10 GLY A 201
ASP A 224
VAL A 228
ASP A 244
ALA A 259
TRP A 264
 SAH  A 601 (-3.7A)
SAH  A 601 (-2.9A)
SAH  A 601 ( 4.9A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.9A)
None
 0.25A 1fpqA-2qyoA:
22.8		 1fpqA-2qyoA:
30.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 GLY A 201
GLY A 202
GLY A 203
ASP A 244
TRP A 264
 SAH  A 601 (-3.7A)
SAH  A 601 ( 4.3A)
SAH  A 601 ( 3.8A)
SAH  A 601 (-3.5A)
None
 0.43A 1qzzA-2qyoA:
3.8		 1qzzA-2qyoA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 GLY A 201
GLY A 202
GLY A 203
ASP A 244
TRP A 264
 SAH  A 601 (-3.7A)
SAH  A 601 ( 4.3A)
SAH  A 601 ( 3.8A)
SAH  A 601 (-3.5A)
None
 0.37A 1xdsA-2qyoA:
12.4		 1xdsA-2qyoA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 GLY A 201
GLY A 202
GLY A 203
ASP A 244
TRP A 264
 SAH  A 601 (-3.7A)
SAH  A 601 ( 4.3A)
SAH  A 601 ( 3.8A)
SAH  A 601 (-3.5A)
None
 0.30A 1xdsB-2qyoA:
22.0		 1xdsB-2qyoA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 ILE A 292
ALA A 254
THR A 207
ASP A 199
PHE A 346
 None
None
SAH  A 601 (-4.0A)
SAH  A 601 ( 4.6A)
None
 1.24A 2qo4A-2qyoA:
undetectable		 2qo4A-2qyoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 ILE A 292
ALA A 254
THR A 207
ASP A 199
PHE A 346
 None
None
SAH  A 601 (-4.0A)
SAH  A 601 ( 4.6A)
None
 1.24A 2qo6A-2qyoA:
undetectable		 2qo6A-2qyoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 GLY A 203
ASP A 224
VAL A 228
ASP A 244
 SAH  A 601 ( 3.8A)
SAH  A 601 (-2.9A)
SAH  A 601 ( 4.9A)
SAH  A 601 (-3.5A)
 0.60A 2uyqA-2qyoA:
9.5		 2uyqA-2qyoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		4 / 8 LEU A 128
PHE A 132
PHE A 147
LEU A 155
 QSO  A 701 (-3.8A)
QSO  A 701 (-4.8A)
None
K  A 362 (-4.4A)
 0.97A 3asoC-2qyoA:
undetectable
3asoJ-2qyoA:
undetectable		 3asoC-2qyoA:
19.63
3asoJ-2qyoA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		3 / 3 PHE A 346
CYH A 187
PHE A 191
 None
 0.58A 3cr5X-2qyoA:
undetectable		 3cr5X-2qyoA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 GLY A 202
GLY A 203
ALA A 259
ASP A 263
TRP A 264
 SAH  A 601 ( 4.3A)
SAH  A 601 ( 3.8A)
SAH  A 601 (-3.9A)
QSO  A 701 (-3.9A)
None
 0.50A 3i5uA-2qyoA:
19.7		 3i5uA-2qyoA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 GLY A 202
GLY A 203
ALA A 259
ASP A 263
TRP A 264
 SAH  A 601 ( 4.3A)
SAH  A 601 ( 3.8A)
SAH  A 601 (-3.9A)
QSO  A 701 (-3.9A)
None
 0.46A 3i5uB-2qyoA:
24.1		 3i5uB-2qyoA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 GLY A 201
GLY A 203
GLY A 205
THR A 207
ASP A 244
 SAH  A 601 (-3.7A)
SAH  A 601 ( 3.8A)
None
SAH  A 601 (-4.0A)
SAH  A 601 (-3.5A)
 0.95A 3ihtA-2qyoA:
7.7		 3ihtA-2qyoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 LEU A 273
VAL A 280
GLY A 287
ILE A 197
LEU A 257
 None
 1.04A 3ijdA-2qyoA:
undetectable		 3ijdA-2qyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 LEU A 273
VAL A 280
GLY A 287
ILE A 197
LEU A 257
 None
 0.98A 3ijdB-2qyoA:
undetectable		 3ijdB-2qyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		3 / 3 GLY A 203
ASP A 224
ASP A 244
 SAH  A 601 ( 3.8A)
SAH  A 601 (-2.9A)
SAH  A 601 (-3.5A)
 0.46A 3ou7C-2qyoA:
14.4		 3ou7C-2qyoA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		3 / 3 GLY A 203
GLY A 205
THR A 207
 SAH  A 601 ( 3.8A)
None
SAH  A 601 (-4.0A)
 0.29A 3si7B-2qyoA:
undetectable		 3si7B-2qyoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 GLY A 201
GLY A 203
VAL A 228
ASP A 263
TRP A 264
 SAH  A 601 (-3.7A)
SAH  A 601 ( 3.8A)
SAH  A 601 ( 4.9A)
QSO  A 701 (-3.9A)
None
 0.62A 4a6eA-2qyoA:
23.7		 4a6eA-2qyoA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		3 / 3 LYS A   9
PRO A  10
SER A  11
 None
 0.35A 4k50I-2qyoA:
undetectable		 4k50I-2qyoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 ILE A 211
CYH A 220
GLY A 202
GLY A 205
PHE A 223
 None
None
SAH  A 601 ( 4.3A)
None
None
 1.13A 4kicB-2qyoA:
14.2		 4kicB-2qyoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		8 / 11 GLY A 201
GLY A 202
THR A 207
ASP A 224
VAL A 228
ASP A 244
MET A 245
LYS A 258
 SAH  A 601 (-3.7A)
SAH  A 601 ( 4.3A)
SAH  A 601 (-4.0A)
SAH  A 601 (-2.9A)
SAH  A 601 ( 4.9A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.9A)
SAH  A 601 (-2.6A)
 0.34A 4pghA-2qyoA:
35.3		 4pghA-2qyoA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		7 / 11 GLY A 201
GLY A 202
THR A 207
VAL A 229
ASP A 244
MET A 245
LYS A 258
 SAH  A 601 (-3.7A)
SAH  A 601 ( 4.3A)
SAH  A 601 (-4.0A)
None
SAH  A 601 (-3.5A)
SAH  A 601 (-3.9A)
SAH  A 601 (-2.6A)
 1.10A 4pghA-2qyoA:
35.3		 4pghA-2qyoA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		9 / 12 ASP A 199
GLY A 201
THR A 207
ASP A 224
ASP A 244
MET A 245
LYS A 258
ASP A 263
TRP A 264
 SAH  A 601 ( 4.6A)
SAH  A 601 (-3.7A)
SAH  A 601 (-4.0A)
SAH  A 601 (-2.9A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.9A)
SAH  A 601 (-2.6A)
QSO  A 701 (-3.9A)
None
 0.52A 4pghB-2qyoA:
28.7		 4pghB-2qyoA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		7 / 11 GLY A 201
ASP A 224
VAL A 228
ASP A 244
MET A 245
LYS A 258
TRP A 264
 SAH  A 601 (-3.7A)
SAH  A 601 (-2.9A)
SAH  A 601 ( 4.9A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.9A)
SAH  A 601 (-2.6A)
None
 0.29A 4pghC-2qyoA:
35.4		 4pghC-2qyoA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		5 / 11 GLY A 201
VAL A 229
ASP A 244
MET A 245
LYS A 258
 SAH  A 601 (-3.7A)
None
SAH  A 601 (-3.5A)
SAH  A 601 (-3.9A)
SAH  A 601 (-2.6A)
 1.09A 4pghC-2qyoA:
35.4		 4pghC-2qyoA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		7 / 12 GLY A 201
GLY A 202
THR A 207
ASP A 224
ASP A 244
PHE A 246
LYS A 258
 SAH  A 601 (-3.7A)
SAH  A 601 ( 4.3A)
SAH  A 601 (-4.0A)
SAH  A 601 (-2.9A)
SAH  A 601 (-3.5A)
SAH  A 601 (-4.7A)
SAH  A 601 (-2.6A)
 0.90A 4pghD-2qyoA:
34.4		 4pghD-2qyoA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		8 / 12 GLY A 201
GLY A 202
THR A 207
ASP A 224
MET A 245
PHE A 246
LYS A 258
TRP A 264
 SAH  A 601 (-3.7A)
SAH  A 601 ( 4.3A)
SAH  A 601 (-4.0A)
SAH  A 601 (-2.9A)
SAH  A 601 (-3.9A)
SAH  A 601 (-4.7A)
SAH  A 601 (-2.6A)
None
 0.78A 4pghD-2qyoA:
34.4		 4pghD-2qyoA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		6 / 12 GLY A 203
THR A 207
ASP A 224
MET A 245
PHE A 246
TRP A 264
 SAH  A 601 ( 3.8A)
SAH  A 601 (-4.0A)
SAH  A 601 (-2.9A)
SAH  A 601 (-3.9A)
SAH  A 601 (-4.7A)
None
 1.40A 4pghD-2qyoA:
34.4		 4pghD-2qyoA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		4 / 6 CYH A 220
GLY A 201
GLY A 202
ASP A 224
 None
SAH  A 601 (-3.7A)
SAH  A 601 ( 4.3A)
SAH  A 601 (-2.9A)
 0.89A 5a06D-2qyoA:
4.9		 5a06D-2qyoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		8 / 11 GLY A 201
GLY A 203
ASP A 224
VAL A 228
ASP A 244
MET A 245
LYS A 258
ASP A 263
 SAH  A 601 (-3.7A)
SAH  A 601 ( 3.8A)
SAH  A 601 (-2.9A)
SAH  A 601 ( 4.9A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.9A)
SAH  A 601 (-2.6A)
QSO  A 701 (-3.9A)
 0.51A 6i5zD-2qyoA:
32.0		 6i5zD-2qyoA:
29.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2qyo O-METHYLTRANSFERASE
(Medicago
truncatula) 		6 / 11 GLY A 202
ASP A 224
ASP A 244
MET A 245
LYS A 258
ASP A 263
 SAH  A 601 ( 4.3A)
SAH  A 601 (-2.9A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.9A)
SAH  A 601 (-2.6A)
QSO  A 701 (-3.9A)
 0.91A 6i5zD-2qyoA:
32.0		 6i5zD-2qyoA:
29.83