SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		3 / 3 ALA A  41
VAL A  10
TRP A  39
 SO4  A 316 (-3.6A)
None
None
 0.92A 1bdwA-2qytA:
undetectable
1bdwB-2qytA:
undetectable		 1bdwA-2qytA:
5.83
1bdwB-2qytA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 10 THR A 179
ALA A 185
PHE A 158
ALA A 180
LEU A  35
 None
 1.18A 1claA-2qytA:
undetectable		 1claA-2qytA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 TYR A 286
LEU A 253
VAL A 204
SER A 203
VAL A 249
 None
 1.36A 1db1A-2qytA:
undetectable		 1db1A-2qytA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 5 TYR A  20
LEU A  55
THR A  59
ARG A  62
 None
None
None
EDO  A 323 (-3.9A)
 1.33A 1i2wA-2qytA:
undetectable		 1i2wA-2qytA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 LEU A 308
ILE A 216
THR A 209
GLN A 257
 None
 1.25A 1kglA-2qytA:
undetectable		 1kglA-2qytA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 GLY A  17
GLY A  18
VAL A  57
LEU A  55
LEU A  24
 EDO  A 320 (-3.6A)
None
None
None
None
 0.88A 1mx1D-2qytA:
undetectable		 1mx1D-2qytA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 5 GLU A 233
LEU A 227
LEU A 230
LEU A 228
 None
 1.16A 1np1A-2qytA:
undetectable		 1np1A-2qytA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 THR A 150
LEU A 151
ILE A 149
PHE A  64
TYR A  20
 None
 1.35A 1wsvB-2qytA:
undetectable		 1wsvB-2qytA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 10 ILE A  40
ALA A  41
ARG A  42
PRO A 102
ILE A 100
 None
SO4  A 316 (-3.6A)
None
None
None
 1.39A 2dm6A-2qytA:
5.8
2dm6B-2qytA:
6.0		 2dm6A-2qytA:
21.21
2dm6B-2qytA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 11 ALA A 141
ILE A 139
VAL A  57
PHE A  64
LEU A  26
 None
 1.25A 2h42A-2qytA:
undetectable		 2h42A-2qytA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 GLY A  21
ALA A  22
MET A  23
LEU A  26
 None
 0.61A 2wekB-2qytA:
5.6		 2wekB-2qytA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 10 GLU A  99
ILE A  40
GLY A  12
ILE A  84
MET A 103
 None
None
SO4  A 318 ( 3.3A)
None
None
 1.06A 3adsA-2qytA:
undetectable		 3adsA-2qytA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A  55
GLY A  14
GLY A  17
LEU A 114
ALA A  41
 None
EDO  A 320 ( 3.3A)
EDO  A 320 (-3.6A)
None
SO4  A 316 (-3.6A)
 1.20A 3i5uA-2qytA:
5.5		 3i5uA-2qytA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A  55
GLY A  14
GLY A  17
LEU A 114
ALA A  41
 None
EDO  A 320 ( 3.3A)
EDO  A 320 (-3.6A)
None
SO4  A 316 (-3.6A)
 1.19A 3i5uB-2qytA:
6.7		 3i5uB-2qytA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 PHE A 238
GLU A 236
VAL A 296
VAL A 287
 None
 1.28A 3jx4A-2qytA:
undetectable
3jx4B-2qytA:
undetectable		 3jx4A-2qytA:
22.89
3jx4B-2qytA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 PHE A 238
GLU A 236
VAL A 296
VAL A 287
 None
 1.28A 3jx5A-2qytA:
undetectable
3jx5B-2qytA:
undetectable		 3jx5A-2qytA:
22.89
3jx5B-2qytA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 6 VAL A 296
VAL A 287
PHE A 238
GLU A 236
 None
 1.31A 3n61A-2qytA:
undetectable
3n61B-2qytA:
undetectable		 3n61A-2qytA:
22.89
3n61B-2qytA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 PHE A 238
GLU A 236
VAL A 296
VAL A 287
 None
 1.26A 3n61A-2qytA:
undetectable
3n61B-2qytA:
undetectable		 3n61A-2qytA:
22.89
3n61B-2qytA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 VAL A 296
VAL A 287
PHE A 238
GLU A 236
 None
 1.24A 3nljA-2qytA:
undetectable
3nljB-2qytA:
undetectable		 3nljA-2qytA:
23.13
3nljB-2qytA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 PHE A 238
GLU A 236
VAL A 296
VAL A 287
 None
 1.29A 3nljA-2qytA:
undetectable
3nljB-2qytA:
undetectable		 3nljA-2qytA:
23.13
3nljB-2qytA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 PHE A 238
GLU A 236
VAL A 296
VAL A 287
 None
 1.23A 3nlqA-2qytA:
undetectable
3nlqB-2qytA:
undetectable		 3nlqA-2qytA:
22.89
3nlqB-2qytA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A  65
GLU A  47
ALA A  48
GLY A  53
ALA A  44
 None
 1.30A 3ou6C-2qytA:
4.7		 3ou6C-2qytA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		3 / 3 THR A  59
SER A  61
ARG A  62
 None
None
EDO  A 323 (-3.9A)
 0.70A 3phnA-2qytA:
undetectable		 3phnA-2qytA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 8 PHE A 238
ALA A 291
PHE A 199
THR A 282
 None
None
None
SO4  A 317 (-3.4A)
 0.91A 3t3sF-2qytA:
undetectable		 3t3sF-2qytA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 5 ASP A  92
GLU A  99
GLY A  96
GLU A  94
 None
 1.39A 3w9tA-2qytA:
undetectable		 3w9tA-2qytA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 5 ASP A  92
GLU A  99
GLY A  96
GLU A  94
 None
 1.39A 3w9tC-2qytA:
undetectable		 3w9tC-2qytA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 5 ASP A  92
GLU A  99
GLY A  96
GLU A  94
 None
 1.39A 3w9tD-2qytA:
undetectable		 3w9tD-2qytA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 5 ASP A  92
GLU A  99
GLY A  96
GLU A  94
 None
 1.39A 3w9tG-2qytA:
undetectable		 3w9tG-2qytA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 5 ASP A  73
THR A  72
LEU A  46
GLU A  47
 None
 1.36A 4a3pA-2qytA:
undetectable		 4a3pA-2qytA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 GLY A  12
ALA A  98
GLY A  96
PHE A  11
TYR A  91
 SO4  A 318 ( 3.3A)
None
None
None
None
 1.27A 4r29A-2qytA:
undetectable		 4r29A-2qytA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 GLY A  12
ALA A  98
GLY A  96
PHE A  11
TYR A  91
 SO4  A 318 ( 3.3A)
None
None
None
None
 1.26A 4r29B-2qytA:
undetectable		 4r29B-2qytA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 GLY A  12
ALA A  98
GLY A  96
PHE A  11
TYR A  91
 SO4  A 318 ( 3.3A)
None
None
None
None
 1.27A 4r29C-2qytA:
undetectable		 4r29C-2qytA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 5 ALA A 141
TYR A  19
PRO A  60
PHE A  64
 None
 1.39A 4ze2A-2qytA:
undetectable		 4ze2A-2qytA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 PHE A 238
GLU A 236
VAL A 296
VAL A 287
 None
 1.24A 5adeA-2qytA:
undetectable
5adeB-2qytA:
undetectable		 5adeA-2qytA:
22.89
5adeB-2qytA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		4 / 7 PHE A 238
GLU A 236
VAL A 296
VAL A 287
 None
 1.28A 5g0pA-2qytA:
undetectable
5g0pB-2qytA:
undetectable		 5g0pA-2qytA:
22.89
5g0pB-2qytA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 LEU A  24
LEU A  85
PHE A 160
THR A 179
ALA A 175
 None
 1.34A 5ieoA-2qytA:
undetectable		 5ieoA-2qytA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 ASP A 118
ASN A 115
ALA A 206
VAL A 287
TYR A 286
 None
 1.28A 5kbwB-2qytA:
1.5		 5kbwB-2qytA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 GLY A 116
ASN A 115
ALA A 206
VAL A 287
TYR A 286
 None
 1.30A 5kbwB-2qytA:
1.5		 5kbwB-2qytA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 2qyt 2-DEHYDROPANTOATE
2-REDUCTASE
(Porphyromonas
gingivalis) 		5 / 12 PHE A 199
ALA A 117
LEU A 298
MET A 300
MET A 304
 None
 1.04A 5tl8A-2qytA:
undetectable		 5tl8A-2qytA:
22.03