SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 TRP A  13
LEU A  12
LEU A 112
GLY A 113
VAL A 105
 None
 1.09A 1axwA-2qyvA:
undetectable		 1axwA-2qyvA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 8 LEU A 325
ASN A 225
LEU A 230
LEU A 231
 None
 1.02A 1e7cA-2qyvA:
undetectable		 1e7cA-2qyvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 8 GLU A 175
LYS A 427
GLU A 425
GLU A 172
 None
 1.03A 1knyA-2qyvA:
undetectable
1knyB-2qyvA:
undetectable		 1knyA-2qyvA:
20.98
1knyB-2qyvA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 6 LEU A  56
ASP A  50
ILE A 441
GLU A 138
 None
 0.98A 1mt1A-2qyvA:
undetectable
1mt1F-2qyvA:
undetectable		 1mt1A-2qyvA:
7.22
1mt1F-2qyvA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 TRP A  13
LEU A  12
LEU A 112
GLY A 113
VAL A 105
 None
 1.10A 1tlsB-2qyvA:
undetectable		 1tlsB-2qyvA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 TRP A  13
LEU A  12
LEU A 112
GLY A 113
VAL A 105
 None
 1.05A 1tsnA-2qyvA:
undetectable		 1tsnA-2qyvA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		3 / 3 SER A 122
ASP A 169
CYH A 435
 None
ZN  A 501 (-1.9A)
None
 1.16A 2br4E-2qyvA:
undetectable		 2br4E-2qyvA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 8 LEU A 480
ILE A 166
ILE A 483
ILE A 408
 None
 0.84A 2bu8A-2qyvA:
undetectable		 2bu8A-2qyvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 7 SER A  26
ASP A  78
ARG A  49
GLU A  30
 None
 0.96A 2cdqB-2qyvA:
undetectable		 2cdqB-2qyvA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 ARG A  68
PRO A 135
VAL A  71
LEU A 411
ILE A 408
 SO4  A 505 (-4.8A)
None
None
None
None
 1.29A 2fj1A-2qyvA:
undetectable		 2fj1A-2qyvA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 TRP A  13
LEU A  12
LEU A 112
GLY A 113
VAL A 105
 None
 1.11A 2kceB-2qyvA:
undetectable		 2kceB-2qyvA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 6 TYR A 472
TYR A 416
GLN A 418
ILE A 415
 None
 1.33A 2pgzD-2qyvA:
undetectable
2pgzE-2qyvA:
undetectable		 2pgzD-2qyvA:
19.02
2pgzE-2qyvA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 GLY A 151
LEU A 165
VAL A  72
TRP A 159
ASP A  50
 None
 0.85A 2vqyA-2qyvA:
undetectable		 2vqyA-2qyvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 GLY A 154
LEU A 165
VAL A  72
TRP A 159
ASP A  50
 None
 1.22A 2vqyA-2qyvA:
undetectable		 2vqyA-2qyvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 11 THR A  62
VAL A 126
VAL A  71
ILE A 166
ALA A 481
 None
 1.22A 2zbzA-2qyvA:
undetectable		 2zbzA-2qyvA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 6 ALA A 186
LEU A 188
SER A 361
VAL A 365
 None
 0.65A 3d2tB-2qyvA:
undetectable		 3d2tB-2qyvA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 9 ALA A 123
LEU A 137
LEU A 480
SER A 162
ILE A 164
 None
 1.28A 3freX-2qyvA:
undetectable		 3freX-2qyvA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 ALA A 186
LEU A 347
SER A 348
SER A 394
GLY A 395
 None
None
None
SO4  A 508 (-4.7A)
SO4  A 508 (-3.5A)
 1.09A 3g2oA-2qyvA:
undetectable		 3g2oA-2qyvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		3 / 3 ARG A 366
ASP A 115
GLN A  74
 SO4  A 503 (-3.0A)
ZN  A 501 ( 2.6A)
None
 0.84A 3lcvB-2qyvA:
undetectable		 3lcvB-2qyvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 ILE A  96
LEU A 112
VAL A 464
HIS A  76
TRP A  13
 None
None
None
ZN  A 501 (-3.4A)
None
 1.20A 3ozuA-2qyvA:
undetectable		 3ozuA-2qyvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 9 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.28A 3p4wA-2qyvA:
undetectable		 3p4wA-2qyvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 8 ILE A 219
ASP A 218
SER A 361
GLY A 350
 None
 0.79A 4acaC-2qyvA:
2.5		 4acaC-2qyvA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 8 ILE A 219
ASP A 218
SER A 361
GLY A 350
 None
 0.80A 4acbC-2qyvA:
2.5		 4acbC-2qyvA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 12 LEU A 234
CYH A 317
ALA A 387
SER A 361
THR A 354
 None
GOL  A 514 ( 4.2A)
None
None
None
 1.12A 4iarA-2qyvA:
undetectable		 4iarA-2qyvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 4 LEU A 127
SER A 122
LEU A 141
LEU A 137
 None
 1.11A 4n09A-2qyvA:
2.4		 4n09A-2qyvA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 11 HIS A  76
ASP A 115
GLU A 145
GLU A 146
GLY A 216
 ZN  A 501 (-3.4A)
ZN  A 501 ( 2.6A)
ZN  A 501 ( 4.2A)
ZN  A 502 (-2.3A)
None
 0.79A 4pqaA-2qyvA:
26.5		 4pqaA-2qyvA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 11 HIS A  76
ASP A 115
GLU A 145
GLU A 146
HIS A 458
 ZN  A 501 (-3.4A)
ZN  A 501 ( 2.6A)
ZN  A 501 ( 4.2A)
ZN  A 502 (-2.3A)
ZN  A 502 ( 3.5A)
 0.32A 4pqaA-2qyvA:
26.5		 4pqaA-2qyvA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 4 THR A 345
GLY A 183
ASP A 396
SER A 367
 None
 1.34A 4rfqA-2qyvA:
undetectable		 4rfqA-2qyvA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		3 / 3 VAL A 217
GLU A 425
GLU A 175
 None
 0.93A 5jsdB-2qyvA:
undetectable
5jsdC-2qyvA:
undetectable		 5jsdB-2qyvA:
20.82
5jsdC-2qyvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 9 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.36A 5mvnB-2qyvA:
1.6		 5mvnB-2qyvA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 10 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.34A 5mvnD-2qyvA:
undetectable		 5mvnD-2qyvA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 10 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.32A 5mzrA-2qyvA:
undetectable		 5mzrA-2qyvA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 10 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.33A 5mzrC-2qyvA:
undetectable		 5mzrC-2qyvA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		5 / 9 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.31A 5mzrD-2qyvA:
undetectable		 5mzrD-2qyvA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 6 GLN A 282
PHE A 233
LEU A 237
PHE A 244
 IPA  A 519 (-4.0A)
None
None
None
 1.09A 5z86C-2qyvA:
undetectable
5z86J-2qyvA:
undetectable		 5z86C-2qyvA:
18.70
5z86J-2qyvA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 6 GLN A 282
PHE A 233
LEU A 237
PHE A 244
 IPA  A 519 (-4.0A)
None
None
None
 1.10A 5z86P-2qyvA:
undetectable
5z86W-2qyvA:
undetectable		 5z86P-2qyvA:
18.70
5z86W-2qyvA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 6 GLN A 282
PHE A 233
LEU A 237
PHE A 244
 IPA  A 519 (-4.0A)
None
None
None
 1.07A 5zcoP-2qyvA:
undetectable
5zcoW-2qyvA:
undetectable		 5zcoP-2qyvA:
18.70
5zcoW-2qyvA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 6 GLN A 282
PHE A 233
LEU A 237
PHE A 244
 IPA  A 519 (-4.0A)
None
None
None
 1.05A 5zcpC-2qyvA:
undetectable
5zcpJ-2qyvA:
undetectable		 5zcpC-2qyvA:
18.70
5zcpJ-2qyvA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 6 GLN A 282
PHE A 233
LEU A 237
PHE A 244
 IPA  A 519 (-4.0A)
None
None
None
 1.10A 5zcpP-2qyvA:
undetectable
5zcpW-2qyvA:
undetectable		 5zcpP-2qyvA:
18.70
5zcpW-2qyvA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2qyv XAA-HIS DIPEPTIDASE
(Histophilus
somni) 		4 / 7 SER A 449
GLY A 432
ALA A 431
LEU A 368
 None
SO4  A 503 (-3.3A)
SO4  A 503 (-3.6A)
None
 0.80A 6dwnB-2qyvA:
undetectable		 6dwnB-2qyvA:
10.33