SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		4 / 8 PRO A 480
PRO A 351
GLY A 352
CYH A 353
 None
ADP  A 700 (-4.8A)
ADP  A 700 (-3.6A)
None
 0.85A 1h4oG-2qz4A:
undetectable		 1h4oG-2qz4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		3 / 3 ASP A 441
PHE A 394
ASN A 434
 None
 0.75A 1sg9B-2qz4A:
3.4		 1sg9B-2qz4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 436
MET A 440
LEU A 328
TYR A 327
 None
 1.36A 1zgyA-2qz4A:
undetectable		 1zgyA-2qz4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 10 MET A 373
ALA A 453
LEU A 465
LEU A 346
LEU A 436
 None
 1.45A 3erdB-2qz4A:
undetectable		 3erdB-2qz4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 12 GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
 None
ADP  A 700 (-3.4A)
None
None
None
 0.88A 3keeA-2qz4A:
undetectable		 3keeA-2qz4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 12 GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
 None
ADP  A 700 (-3.4A)
None
None
None
 0.88A 3keeB-2qz4A:
undetectable		 3keeB-2qz4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 12 GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
 None
ADP  A 700 (-3.4A)
None
None
None
 0.80A 3keeC-2qz4A:
undetectable		 3keeC-2qz4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 12 GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
 None
ADP  A 700 (-3.4A)
None
None
None
 0.81A 3keeD-2qz4A:
undetectable		 3keeD-2qz4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 6 ALA A 548
ILE A 524
LEU A 509
GLU A 546
GLU A 550
 None
 1.36A 3r9sA-2qz4A:
undetectable		 3r9sA-2qz4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		3 / 3 GLY A 352
GLY A 354
THR A 356
 ADP  A 700 (-3.6A)
ADP  A 700 (-3.4A)
ADP  A 700 (-3.8A)
 0.45A 3si7B-2qz4A:
4.8		 3si7B-2qz4A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 12 GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
 None
ADP  A 700 (-3.4A)
None
None
None
 0.96A 3sudC-2qz4A:
undetectable		 3sudC-2qz4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 11 LEU A 437
LEU A 465
THR A 455
ALA A 453
VAL A 451
 None
 1.15A 4x20D-2qz4A:
undetectable		 4x20D-2qz4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 12 ALA A 522
GLY A 518
CYH A 353
GLY A 352
LEU A 496
 ADP  A 700 ( 4.0A)
ADP  A 700 (-3.4A)
None
ADP  A 700 (-3.6A)
None
 1.12A 5ybbA-2qz4A:
undetectable		 5ybbA-2qz4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2qz4 PARAPLEGIN
(Homo
sapiens) 		5 / 12 GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
 None
ADP  A 700 (-3.4A)
None
None
None
 0.86A 6c2mD-2qz4A:
undetectable		 6c2mD-2qz4A:
17.51