SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 6 GLN A 120
TYR A 222
VAL A 212
GLY A 215
 None
 1.12A 1ekjC-2qz6A:
undetectable
1ekjD-2qz6A:
undetectable		 1ekjC-2qz6A:
21.47
1ekjD-2qz6A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 6 VAL A 212
GLY A 215
GLN A 120
TYR A 222
 None
 1.13A 1ekjC-2qz6A:
undetectable
1ekjD-2qz6A:
undetectable		 1ekjC-2qz6A:
21.47
1ekjD-2qz6A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 8 LEU A 357
TYR A 328
GLY A 333
LEU A 312
 None
 0.79A 1jlbA-2qz6A:
undetectable		 1jlbA-2qz6A:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 10 GLN A 120
ASN A 152
TYR A 222
LYS A 315
THR A 316
GLY A 317
 None
 0.78A 1kvlA-2qz6A:
55.3		 1kvlA-2qz6A:
49.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 10 GLN A 120
TYR A 150
ASN A 152
TYR A 222
THR A 316
GLY A 317
 None
 0.82A 1kvlA-2qz6A:
55.3		 1kvlA-2qz6A:
49.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 10 GLY A  63
GLN A 120
ASN A 152
TYR A 222
THR A 316
GLY A 317
 None
 1.29A 1kvlA-2qz6A:
55.3		 1kvlA-2qz6A:
49.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 10 GLY A  63
LEU A 119
ASN A 152
TYR A 222
THR A 316
GLY A 317
 None
 1.17A 1kvlA-2qz6A:
55.3		 1kvlA-2qz6A:
49.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 10 LEU A 119
ASN A 152
TYR A 222
LYS A 315
THR A 316
GLY A 317
 None
 0.43A 1kvlA-2qz6A:
55.3		 1kvlA-2qz6A:
49.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 10 LEU A 119
TYR A 150
ASN A 152
TYR A 222
THR A 316
GLY A 317
 None
 0.61A 1kvlA-2qz6A:
55.3		 1kvlA-2qz6A:
49.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 THR A  58
ASN A 341
ILE A  25
LEU A  19
VAL A  16
 None
 1.19A 1r30A-2qz6A:
undetectable		 1r30A-2qz6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 THR A  58
ASN A 341
ILE A  25
LEU A  19
VAL A  16
 None
 1.20A 1r30B-2qz6A:
undetectable		 1r30B-2qz6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 11 THR A 319
GLY A 321
GLY A 202
ILE A  62
LEU A 339
ALA A 324
 None
 1.44A 1x7pA-2qz6A:
undetectable
1x7pB-2qz6A:
undetectable		 1x7pA-2qz6A:
19.90
1x7pB-2qz6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 10 THR A 319
GLY A 321
GLY A 202
ILE A  62
LEU A 339
ALA A 324
 None
 1.47A 1x7pA-2qz6A:
undetectable
1x7pB-2qz6A:
undetectable		 1x7pA-2qz6A:
19.90
1x7pB-2qz6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A 162
ALA A 163
LEU A 173
ALA A  77
ILE A 224
 None
 1.00A 2aclA-2qz6A:
undetectable
2aclE-2qz6A:
undetectable		 2aclA-2qz6A:
20.89
2aclE-2qz6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 11 ALA A 162
ALA A 163
LEU A 173
ALA A  77
ILE A 224
 None
 1.08A 2aclE-2qz6A:
undetectable		 2aclE-2qz6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 11 LEU A 283
ASN A 314
VAL A 336
ALA A 353
LEU A 357
 None
 1.18A 2bxgA-2qz6A:
undetectable		 2bxgA-2qz6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 6 LEU A  96
TYR A 135
ILE A 132
GLY A 159
 None
 0.74A 2du8A-2qz6A:
undetectable		 2du8A-2qz6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 6 LEU A  96
TYR A 135
ILE A 132
GLY A 159
 None
 0.77A 2du8B-2qz6A:
undetectable		 2du8B-2qz6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A 221
GLY A 223
MET A 174
LEU A 179
LEU A 182
 None
 0.94A 2hw2A-2qz6A:
undetectable		 2hw2A-2qz6A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 6 GLY A 116
PHE A 142
PRO A 144
THR A 113
 None
 1.13A 2m2oB-2qz6A:
undetectable		 2m2oB-2qz6A:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 10 LEU A 157
GLY A 159
LEU A 161
LEU A 106
ALA A  89
 None
 0.99A 2v3kA-2qz6A:
undetectable		 2v3kA-2qz6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 LYS A  67
ASN A 152
LYS A 315
THR A 316
GLY A 317
 None
 0.56A 3huoA-2qz6A:
15.7		 3huoA-2qz6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 12 SER A  64
LYS A  67
ASN A 152
GLY A 317
THR A 319
ARG A 349
 None
 1.09A 3mzeA-2qz6A:
14.8		 3mzeA-2qz6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 12 SER A  64
LYS A  67
ASN A 152
THR A 316
GLY A 317
THR A 319
 None
 0.82A 3mzeA-2qz6A:
14.8		 3mzeA-2qz6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 4 GLY A 258
GLY A 268
THR A 111
LEU A 107
 None
 0.72A 3si7C-2qz6A:
undetectable
3si7D-2qz6A:
undetectable		 3si7C-2qz6A:
21.00
3si7D-2qz6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 9 LEU A  85
ALA A 162
GLY A 156
ILE A 155
LEU A 107
 None
 0.92A 3u7sA-2qz6A:
undetectable		 3u7sA-2qz6A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 224
THR A 187
THR A  72
LEU A 184
LEU A 182
 None
 0.90A 4c9lA-2qz6A:
undetectable		 4c9lA-2qz6A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 224
THR A 187
THR A  72
LEU A 184
LEU A 182
 None
 0.89A 4c9lB-2qz6A:
undetectable		 4c9lB-2qz6A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 224
THR A 187
THR A  72
LEU A 184
LEU A 182
 None
 0.92A 4c9oA-2qz6A:
undetectable		 4c9oA-2qz6A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 224
THR A 187
THR A  72
LEU A 184
LEU A 182
 None
 0.92A 4c9oB-2qz6A:
undetectable		 4c9oB-2qz6A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		3 / 3 LYS A  48
ARG A 211
VAL A 210
 None
 1.06A 4x3uA-2qz6A:
undetectable
4x3uB-2qz6A:
undetectable		 4x3uA-2qz6A:
11.21
4x3uB-2qz6A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 8 ASN A 346
ALA A 347
VAL A 350
GLU A 285
 None
 0.71A 4zbqA-2qz6A:
undetectable		 4zbqA-2qz6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 12 THR A 319
GLY A 321
GLY A 202
ILE A  62
LEU A 339
ALA A 324
 None
 1.41A 5l0zA-2qz6A:
undetectable		 5l0zA-2qz6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		6 / 10 THR A 319
GLY A 321
GLY A 202
ILE A  62
LEU A 339
ALA A 324
 None
 1.44A 5l0zB-2qz6A:
undetectable		 5l0zB-2qz6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 8 GLY A 156
GLU A 220
ALA A 219
PHE A 121
 None
 0.84A 5mvsB-2qz6A:
undetectable		 5mvsB-2qz6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A 162
ALA A 163
LEU A 173
ALA A  77
ILE A 224
 None
 0.91A 6a60D-2qz6A:
undetectable		 6a60D-2qz6A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2qz6 BETA-LACTAMASE
(Pseudomonas
fluorescens) 		4 / 6 GLN A 267
VAL A 313
LEU A 107
PRO A 304
 None
 1.27A 6brdB-2qz6A:
undetectable		 6brdB-2qz6A:
13.75