SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 125
ALA A 129
SER A 105
LEU A  88
ALA A  84
 None
 1.06A 3dzyA-2qz8A:
undetectable		 3dzyA-2qz8A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 6 MET A 108
VAL A  94
LEU A  66
ILE A  73
ILE A  91
 None
 1.43A 3gcsA-2qz8A:
undetectable		 3gcsA-2qz8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 SER A 105
ALA A  72
VAL A  71
 None
 0.56A 4o2bA-2qz8A:
undetectable		 4o2bA-2qz8A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 SER A 105
ALA A  72
VAL A  71
 None
 0.55A 4o2bC-2qz8A:
undetectable		 4o2bC-2qz8A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 SER A 105
ALA A  72
VAL A  71
 None
 0.54A 4x1iA-2qz8A:
undetectable		 4x1iA-2qz8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 SER A 105
ALA A  72
VAL A  71
 None
 0.53A 5eypA-2qz8A:
undetectable		 5eypA-2qz8A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  90
ARG A 124
ILE A  91
 None
 0.83A 6fgdA-2qz8A:
undetectable		 6fgdA-2qz8A:
18.57