SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qz9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 ASP A 104
ASP A 106
LYS A 224
 None
 1.06A 1lqtB-2qz9A:
5.7		 1lqtB-2qz9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 ASP A 104
ASP A 106
LYS A 224
 None
 1.05A 1lquB-2qz9A:
5.8		 1lquB-2qz9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 VAL A 149
GLY A 150
VAL A 252
ILE A 309
 None
 0.81A 2a1mB-2qz9A:
undetectable		 2a1mB-2qz9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ILE A 136
LEU A 139
ASN A 115
VAL A 114
 None
 0.78A 3dcjB-2qz9A:
5.4		 3dcjB-2qz9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 VAL A 327
ALA A 326
GLU A  23
VAL A   8
ILE A  10
 None
 1.07A 3dl9A-2qz9A:
undetectable		 3dl9A-2qz9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 ILE A 151
ARG A 300
ILE A 145
THR A 222
 None
 1.06A 3ia4C-2qz9A:
undetectable		 3ia4C-2qz9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 GLU A  34
VAL A  55
GLN A  58
ALA A   9
 None
 1.01A 3kp6B-2qz9A:
undetectable		 3kp6B-2qz9A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 ALA A 260
GLY A 297
VAL A 296
VAL A 252
ILE A 309
 None
 1.04A 3oxvD-2qz9A:
undetectable		 3oxvD-2qz9A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 TYR A  48
THR A  14
GLU A  23
 None
 0.79A 4df3B-2qz9A:
undetectable		 4df3B-2qz9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASN A 130
PRO A 131
GLN A 328
ILE A 119
 None
 1.08A 4iilA-2qz9A:
6.2		 4iilA-2qz9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ILE A 107
VAL A  93
ALA A   9
ALA A  71
GLY A  12
 None
 1.00A 5igjA-2qz9A:
undetectable		 5igjA-2qz9A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ILE A 107
VAL A  93
ALA A   9
ALA A  71
GLY A  12
 None
 1.01A 5igtA-2qz9A:
undetectable		 5igtA-2qz9A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 ASN A 234
TYR A 211
CYH A 237
 None
 0.82A 5lsuB-2qz9A:
undetectable		 5lsuB-2qz9A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 VAL A 240
TYR A 159
GLN A 160
 None
 0.59A 5qgkA-2qz9A:
undetectable		 5qgkA-2qz9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 VAL A 240
TYR A 159
GLN A 160
 None
 0.56A 5qgrA-2qz9A:
undetectable		 5qgrA-2qz9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 VAL A 240
TYR A 159
GLN A 160
 None
 0.55A 5qgtA-2qz9A:
undetectable		 5qgtA-2qz9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 PHE A   6
ASP A  33
LEU A  38
 None
 0.71A 5uhbC-2qz9A:
undetectable		 5uhbC-2qz9A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 PHE A   6
ASP A  33
LEU A  38
 None
 0.79A 5uhcC-2qz9A:
undetectable		 5uhcC-2qz9A:
14.63