SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qzc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		5 / 12 VAL A  14
GLY A  15
ASN A  19
PHE A 191
GLU A 198
 None
None
None
None
IMD  A 214 (-2.7A)
 1.17A 1a27A-2qzcA:
undetectable		 1a27A-2qzcA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K1Y_A_ACRA660_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		5 / 12 HIS A  88
TYR A 114
ASP A  47
TYR A 140
GLU A 198
 None
IMD  A 214 ( 4.9A)
GOL  A 215 ( 3.1A)
GOL  A 215 ( 3.5A)
IMD  A 214 (-2.7A)
 1.48A 1k1yA-2qzcA:
0.5		 1k1yA-2qzcA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		5 / 12 GLU A  52
ILE A 102
ILE A  45
GLN A  46
ARG A  99
 None
 1.49A 1ki7A-2qzcA:
undetectable		 1ki7A-2qzcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		5 / 12 GLU A  52
ILE A 102
GLN A  46
TYR A 107
ARG A  99
 None
 1.46A 1ki7B-2qzcA:
undetectable		 1ki7B-2qzcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		5 / 12 GLU A  52
ILE A 102
ILE A  45
GLN A  46
ARG A  99
 None
 1.25A 1ki7B-2qzcA:
undetectable		 1ki7B-2qzcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		4 / 6 TYR A 140
TYR A 162
HIS A  88
GLU A 198
 GOL  A 215 ( 3.5A)
GOL  A 215 (-4.7A)
None
IMD  A 214 (-2.7A)
 1.24A 1q13A-2qzcA:
undetectable		 1q13A-2qzcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		4 / 8 TYR A  50
ASP A  47
TYR A 140
HIS A  24
 IMD  A 214 (-3.7A)
GOL  A 215 ( 3.1A)
GOL  A 215 ( 3.5A)
None
 1.48A 2ha2B-2qzcA:
undetectable		 2ha2B-2qzcA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		4 / 8 HIS A  88
GLY A  84
TRP A 158
TYR A 167
 None
None
None
GOL  A 215 (-4.8A)
 1.25A 3ccfA-2qzcA:
undetectable		 3ccfA-2qzcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		4 / 8 ILE A 174
TRP A 126
TRP A 133
PHE A 129
 None
 1.43A 3ccfB-2qzcA:
undetectable		 3ccfB-2qzcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		4 / 5 HIS A  88
LEU A  37
LEU A  35
ASP A  38
 None
 1.18A 4aqlA-2qzcA:
undetectable		 4aqlA-2qzcA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		4 / 6 ILE A  39
GLU A 198
HIS A  24
VAL A 143
 None
IMD  A 214 (-2.7A)
None
None
 1.12A 4ejwB-2qzcA:
undetectable		 4ejwB-2qzcA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		4 / 9 HIS A  88
PHE A  40
ILE A  27
MET A  30
 None
 1.35A 4jvlA-2qzcA:
undetectable		 4jvlA-2qzcA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1
(Sulfolobus
solfataricus) 		3 / 3 HIS A  88
LYS A  83
PHE A 161
 None
 0.64A 5klaA-2qzcA:
undetectable		 5klaA-2qzcA:
20.00