SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2qzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 10 ARG A  71
LEU A  54
LEU A   8
ALA A  40
GLY A  42
 None
 1.12A 1cmcA-2qzjA:
undetectable
1cmcB-2qzjA:
undetectable		 1cmcA-2qzjA:
20.74
1cmcB-2qzjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		3 / 3 ASP A 100
PHE A  53
VAL A 115
 None
 0.73A 1kijB-2qzjA:
undetectable		 1kijB-2qzjA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 12 ALA A  40
GLY A  42
ARG A  71
LEU A  54
LEU A   8
 None
 1.07A 1mj2A-2qzjA:
undetectable
1mj2B-2qzjA:
undetectable		 1mj2A-2qzjA:
20.74
1mj2B-2qzjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 12 ALA A  40
GLY A  42
ARG A  71
LEU A  54
LEU A   8
 None
 1.08A 1mj2C-2qzjA:
undetectable
1mj2D-2qzjA:
undetectable		 1mj2C-2qzjA:
20.74
1mj2D-2qzjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 12 ALA A  40
GLY A  42
ARG A  71
LEU A  54
LEU A   8
 None
 1.11A 1mjoC-2qzjA:
undetectable
1mjoD-2qzjA:
undetectable		 1mjoC-2qzjA:
20.74
1mjoD-2qzjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 12 GLU A  38
ASN A  36
ILE A  70
GLY A  42
ILE A  41
 None
 1.34A 1q8jA-2qzjA:
4.1		 1q8jA-2qzjA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 9 GLY A  63
GLU A  55
MET A  81
LEU A  66
ILE A  70
 None
 1.43A 3nbqA-2qzjA:
3.3		 3nbqA-2qzjA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		4 / 5 LEU A  58
GLY A  12
MET A  81
ASN A  16
 None
 1.33A 3uq6B-2qzjA:
undetectable		 3uq6B-2qzjA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		4 / 8 VAL A  79
CYH A  67
TYR A  80
ILE A  52
 None
 1.19A 4bqtC-2qzjA:
undetectable
4bqtD-2qzjA:
undetectable		 4bqtC-2qzjA:
19.72
4bqtD-2qzjA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 11 LEU A 108
LEU A 111
LEU A  20
GLU A  25
LEU A  24
 None
 1.00A 4wg0B-2qzjA:
undetectable
4wg0C-2qzjA:
undetectable
4wg0D-2qzjA:
undetectable		 4wg0B-2qzjA:
5.88
4wg0C-2qzjA:
5.88
4wg0D-2qzjA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 11 LEU A 108
LEU A 111
LEU A  20
GLU A  25
LEU A  24
 None
 1.01A 4wg0D-2qzjA:
undetectable
4wg0E-2qzjA:
undetectable
4wg0F-2qzjA:
undetectable		 4wg0D-2qzjA:
5.88
4wg0E-2qzjA:
5.88
4wg0F-2qzjA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 11 GLU A  25
LEU A  24
LEU A  20
LEU A 108
LEU A 111
 None
 0.99A 4wg0C-2qzjA:
undetectable
4wg0D-2qzjA:
undetectable
4wg0E-2qzjA:
undetectable		 4wg0C-2qzjA:
5.88
4wg0D-2qzjA:
5.88
4wg0E-2qzjA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 11 LEU A 108
LEU A 111
LEU A  20
GLU A  25
LEU A  24
 None
 1.00A 4wg0F-2qzjA:
undetectable
4wg0G-2qzjA:
undetectable
4wg0H-2qzjA:
undetectable		 4wg0F-2qzjA:
5.88
4wg0G-2qzjA:
5.88
4wg0H-2qzjA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2qzj TWO-COMPONENT
RESPONSE REGULATOR
(Clostridioides
difficile) 		5 / 11 GLU A  25
LEU A  24
LEU A  20
LEU A 108
LEU A 111
 None
 0.99A 4wg0G-2qzjA:
undetectable
4wg0H-2qzjA:
undetectable
4wg0I-2qzjA:
undetectable		 4wg0G-2qzjA:
5.88
4wg0H-2qzjA:
5.88
4wg0I-2qzjA:
5.88