SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r01'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2r01 NITROREDUCTASE
FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 4 ALA A  94
VAL A  33
ALA A  32
HIS A  30
 None
 1.19A 1q23A-2r01A:
undetectable		 1q23A-2r01A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2r01 NITROREDUCTASE
FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 4 ALA A  94
VAL A  33
ALA A  32
HIS A  30
 None
 1.19A 1q23K-2r01A:
undetectable		 1q23K-2r01A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2r01 NITROREDUCTASE
FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 ASP A  35
LEU A  38
HIS A  30
 None
 0.49A 1qknA-2r01A:
undetectable		 1qknA-2r01A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2r01 NITROREDUCTASE
FAMILY PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 GLY A 108
ALA A 109
ASP A 112
THR A 153
 None
 0.76A 4eyrB-2r01A:
undetectable		 4eyrB-2r01A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2r01 NITROREDUCTASE
FAMILY PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 GLY A 186
GLU A 165
THR A 166
 None
EDO  A 213 (-2.9A)
None
 0.58A 4kouA-2r01A:
undetectable		 4kouA-2r01A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2r01 NITROREDUCTASE
FAMILY PROTEIN
(Chlorobaculum
tepidum) 		5 / 12 TRP A  77
ALA A 117
GLY A 131
ARG A  25
PHE A  27
 None
None
None
FMN  A 212 (-3.8A)
None
 1.25A 6clxA-2r01A:
undetectable		 6clxA-2r01A:
23.26