SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 391
LEU A 396
VAL A 395
GLN A 622
ARG A 566
 None
 1.05A 1kt4A-2r05A:
undetectable		 1kt4A-2r05A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 391
LEU A 396
VAL A 395
GLN A 622
ARG A 566
 None
 1.07A 1kt6A-2r05A:
undetectable		 1kt6A-2r05A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 391
LEU A 396
VAL A 395
GLN A 622
ARG A 566
 None
 1.05A 1kt7A-2r05A:
undetectable		 1kt7A-2r05A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 530
PRO A 414
VAL A 413
ILE A 534
 None
 0.98A 2aoiB-2r05A:
undetectable		 2aoiB-2r05A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 ALA A 463
ASP A 467
GLU A 462
ARG A 489
 None
 1.11A 2ouzA-2r05A:
undetectable		 2ouzA-2r05A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 TYR A 608
LEU A 604
ARG A 380
LEU A 573
 None
 0.85A 3f33A-2r05A:
4.2		 3f33A-2r05A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 6 VAL A 343
SER A 188
ILE A 190
ALA A 128
LEU A 124
 None
 1.34A 3kk6B-2r05A:
undetectable		 3kk6B-2r05A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  65
LEU A 124
ILE A 347
THR A 341
ALA A 128
 None
 0.93A 3mdvB-2r05A:
undetectable		 3mdvB-2r05A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 455
ARG A 456
GLY A 492
CYH A 691
LEU A 457
 None
 1.35A 3okxA-2r05A:
undetectable		 3okxA-2r05A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		3 / 3 PHE A 663
SER A 423
GLN A 427
 None
 0.99A 3smtA-2r05A:
undetectable		 3smtA-2r05A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 SER A 132
LEU A 237
VAL A 241
PHE A 125
ALA A  98
 None
 1.42A 3u9fD-2r05A:
undetectable
3u9fE-2r05A:
undetectable		 3u9fD-2r05A:
14.59
3u9fE-2r05A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 SER A 132
LEU A 237
VAL A 241
PHE A 125
ALA A  98
 None
 1.37A 3u9fG-2r05A:
undetectable
3u9fH-2r05A:
undetectable		 3u9fG-2r05A:
14.59
3u9fH-2r05A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		3 / 3 THR A 674
ASN A 678
GLU A 439
 None
 0.68A 3v4tA-2r05A:
undetectable
3v4tC-2r05A:
undetectable		 3v4tA-2r05A:
21.32
3v4tC-2r05A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 8 SER A 416
ARG A 649
ILE A 417
GLU A 406
 None
 1.00A 4cx7A-2r05A:
undetectable
4cx7B-2r05A:
undetectable		 4cx7A-2r05A:
20.55
4cx7B-2r05A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 8 SER A 416
ARG A 649
ILE A 417
GLU A 406
 None
 0.95A 4cx7C-2r05A:
0.0
4cx7D-2r05A:
undetectable		 4cx7C-2r05A:
20.55
4cx7D-2r05A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 8 ALA A 490
THR A 493
LEU A 455
LEU A 458
 None
 0.91A 4ejgB-2r05A:
undetectable		 4ejgB-2r05A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 7 GLU A  62
LYS A 151
TYR A 153
HIS A 152
 None
 1.39A 4uciB-2r05A:
undetectable		 4uciB-2r05A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_A_ACTA404_0
(PROTON-GATED ION
CHANNEL)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 484
ILE A 694
ARG A 478
TYR A 485
 None
 1.39A 4zzbA-2r05A:
4.3		 4zzbA-2r05A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 484
ILE A 694
ARG A 478
TYR A 485
 None
 1.47A 4zzcA-2r05A:
4.6		 4zzcA-2r05A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 666
ARG A 517
ILE A 520
ILE A 430
 None
 1.25A 5dzk2-2r05A:
undetectable
5dzkM-2r05A:
undetectable
5dzkN-2r05A:
undetectable		 5dzk2-2r05A:
2.94
5dzkM-2r05A:
14.98
5dzkN-2r05A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A  50
TYR A  71
GLU A 119
LEU A  21
 None
 1.18A 5umwB-2r05A:
undetectable
5umwE-2r05A:
undetectable		 5umwB-2r05A:
6.98
5umwE-2r05A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 534
PRO A 414
ALA A 659
THR A 658
 None
 0.95A 6cduC-2r05A:
2.9
6cduD-2r05A:
2.6		 6cduC-2r05A:
19.25
6cduD-2r05A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 271
ASN A 315
ASP A 321
ARG A 322
 None
 1.37A 6dwdB-2r05A:
undetectable
6dwdD-2r05A:
undetectable		 6dwdB-2r05A:
22.28
6dwdD-2r05A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 ALA A 128
ALA A 131
ALA A 156
ALA A 159
 None
 0.76A 6gtqA-2r05A:
undetectable
6gtqB-2r05A:
undetectable		 6gtqA-2r05A:
12.55
6gtqB-2r05A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 ALA A 156
ALA A 159
ALA A 128
ALA A 131
 None
 0.76A 6gtqA-2r05A:
undetectable
6gtqB-2r05A:
undetectable		 6gtqA-2r05A:
12.55
6gtqB-2r05A:
12.55