SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 LEU A 231
LEU A 235
GLN A 147
CYH A 190
THR A 189
 None
None
SO4  A 400 (-3.8A)
None
None
 1.38A 1a28B-2r09A:
undetectable		 1a28B-2r09A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ILE A 197
ILE A 198
MET A 169
ALA A 173
LEU A 388
 None
None
None
None
PE5  A 407 (-3.6A)
 1.13A 1bsxA-2r09A:
undetectable		 1bsxA-2r09A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ILE A 197
ILE A 198
MET A 169
ALA A 173
PHE A 262
 None
 0.99A 1bsxA-2r09A:
undetectable		 1bsxA-2r09A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ILE A 197
ILE A 198
MET A 169
ALA A 173
LEU A 388
 None
None
None
None
PE5  A 407 (-3.6A)
 1.13A 1bsxB-2r09A:
undetectable		 1bsxB-2r09A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ILE A 197
ILE A 198
MET A 169
ALA A 173
PHE A 262
 None
 0.99A 1bsxB-2r09A:
undetectable		 1bsxB-2r09A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2r09 CYTOHESIN-3
(Mus
musculus) 		4 / 5 TYR A 295
GLU A 297
PRO A 304
ASP A 301
 4IP  A 405 (-4.5A)
None
None
SO4  A 404 (-4.2A)
 1.47A 1i7zB-2r09A:
0.0		 1i7zB-2r09A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2r09 CYTOHESIN-3
(Mus
musculus) 		4 / 7 ARG A 157
ASN A 256
ASP A 254
GLY A 160
 None
PGE  A 406 ( 4.6A)
None
None
 1.05A 2f6dA-2r09A:
undetectable		 2f6dA-2r09A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 10 ILE A 225
PHE A 218
LEU A 145
VAL A 146
LEU A 239
 PE5  A 407 ( 4.4A)
None
None
None
None
 1.35A 2w98A-2r09A:
undetectable		 2w98A-2r09A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 2r09 CYTOHESIN-3
(Mus
musculus) 		4 / 6 TYR A 294
LEU A 310
ASN A 291
ASP A 382
 None
 1.42A 2w98A-2r09A:
undetectable
2w98B-2r09A:
undetectable		 2w98A-2r09A:
20.31
2w98B-2r09A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 PHE A 134
PHE A 140
ALA A 148
THR A 259
LEU A 158
 None
 1.39A 2x2nD-2r09A:
undetectable		 2x2nD-2r09A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ILE A 197
ILE A 198
MET A 169
ALA A 173
PHE A 262
 None
 1.09A 3gwsX-2r09A:
undetectable		 3gwsX-2r09A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 GLU A 122
GLY A 121
VAL A 130
GLY A 117
PHE A 156
 None
 0.99A 3sglA-2r09A:
undetectable		 3sglA-2r09A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ASN A 112
GLY A 108
GLY A  84
GLU A  90
ASN A  91
 None
 1.29A 3v3oB-2r09A:
undetectable		 3v3oB-2r09A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2r09 CYTOHESIN-3
(Mus
musculus) 		4 / 5 LEU A  88
GLY A  84
ILE A 116
VAL A 115
 None
 0.78A 3wriA-2r09A:
undetectable		 3wriA-2r09A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2r09 CYTOHESIN-3
(Mus
musculus) 		4 / 5 LEU A  88
GLY A  84
ILE A 116
VAL A 115
 None
 0.77A 3wriB-2r09A:
undetectable		 3wriB-2r09A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2r09 CYTOHESIN-3
(Mus
musculus) 		4 / 5 LEU A  88
GLY A  84
ILE A 116
VAL A 115
 None
 0.84A 3wrkA-2r09A:
undetectable		 3wrkA-2r09A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2r09 CYTOHESIN-3
(Mus
musculus) 		4 / 6 LYS A  82
ILE A  85
VAL A 101
LEU A 105
 None
 0.82A 4em2A-2r09A:
undetectable		 4em2A-2r09A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 TYR A 295
PHE A 286
LEU A 329
LEU A 293
HIS A 355
 4IP  A 405 (-4.5A)
None
None
None
4IP  A 405 (-3.9A)
 1.36A 4j03A-2r09A:
undetectable		 4j03A-2r09A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2r09 CYTOHESIN-3
(Mus
musculus) 		3 / 3 LEU A 158
PRO A 159
ARG A 391
 None
 0.58A 4klrB-2r09A:
undetectable		 4klrB-2r09A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2r09 CYTOHESIN-3
(Mus
musculus) 		3 / 3 MET A 199
MET A 169
TYR A 385
 PE5  A 407 ( 3.9A)
None
PE5  A 407 (-3.7A)
 1.17A 4p6xI-2r09A:
undetectable		 4p6xI-2r09A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 LEU A 105
LEU A 158
LEU A 153
PHE A 134
ALA A 171
 None
 1.31A 5ieoA-2r09A:
undetectable		 5ieoA-2r09A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 ILE A 225
ILE A 219
LEU A 193
LEU A 235
LEU A 239
 PE5  A 407 ( 4.4A)
None
None
None
None
 1.20A 5tiwA-2r09A:
undetectable		 5tiwA-2r09A:
20.68