SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 7 GLY A 123
PRO A  40
SER A 127
HIS A 119
ALA A  44
 SO4  A   1 (-3.8A)
None
SO4  A   1 (-2.7A)
None
None
 1.36A 1gxsA-2r0bA:
2.5
1gxsB-2r0bA:
undetectable		 1gxsA-2r0bA:
18.68
1gxsB-2r0bA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  85
ILE A  95
PHE A  99
GLY A 120
LEU A  38
 None
None
None
SO4  A   1 (-3.5A)
None
 1.07A 2lbdA-2r0bA:
undetectable		 2lbdA-2r0bA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 102
PHE A 130
ILE A  95
ASN A  94
PHE A  99
 None
 1.28A 2vdyA-2r0bA:
undetectable		 2vdyA-2r0bA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 102
PHE A 130
ILE A  95
ASN A  94
PHE A  99
 None
 1.15A 2vdyB-2r0bA:
undetectable		 2vdyB-2r0bA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 110
GLY A  56
GLY A  35
LEU A  36
HIS A  59
 None
 1.17A 3e23A-2r0bA:
undetectable		 3e23A-2r0bA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 102
PHE A 130
ILE A  95
ASN A  94
PHE A  99
 None
 1.27A 4c49A-2r0bA:
undetectable		 4c49A-2r0bA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 102
PHE A 130
ILE A  95
ASN A  94
PHE A  99
 None
 1.29A 4c49B-2r0bA:
undetectable		 4c49B-2r0bA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 102
PHE A 130
ILE A  95
ASN A  94
PHE A  99
 None
 1.24A 4c49C-2r0bA:
undetectable		 4c49C-2r0bA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EUM_B_ACTB603_0
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 ALA A 122
ASN A 121
ARG A  26
ILE A 124
 SO4  A   1 (-3.6A)
None
None
SO4  A   1 (-4.1A)
 1.21A 5eumB-2r0bA:
0.0		 5eumB-2r0bA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 7 SER A  43
LEU A 117
ILE A  32
LEU A  36
 None
 0.78A 5te8C-2r0bA:
undetectable		 5te8C-2r0bA:
16.59