SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		5 / 8 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.50A 1aq7A-2r0lA:
35.0		 1aq7A-2r0lA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		6 / 9 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.39A 1bcuH-2r0lA:
35.3		 1bcuH-2r0lA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.30A 1dwcH-2r0lA:
35.0		 1dwcH-2r0lA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		6 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.46A 1etrH-2r0lA:
34.7		 1etrH-2r0lA:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		5 / 8 ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
 0.56A 1f5lA-2r0lA:
37.3		 1f5lA-2r0lA:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 7 GLY A 216
ASP A 102
HIS A  57
ALA A  55
 None
 1.00A 1gxsA-2r0lA:
undetectable
1gxsB-2r0lA:
undetectable		 1gxsA-2r0lA:
19.93
1gxsB-2r0lA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 4 LEU A 199
GLY A 184
ASP A 189
TYR A 228
 None
 1.32A 1oxrA-2r0lA:
undetectable		 1oxrA-2r0lA:
20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.33A 1tnlA-2r0lA:
18.4		 1tnlA-2r0lA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 7 GLU A  86
PRO A  60
ARG A  61
GLY A  84
 None
 0.82A 2hs1B-2r0lA:
undetectable		 2hs1B-2r0lA:
12.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.34A 2otvA-2r0lA:
18.5		 2otvA-2r0lA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		7 / 12 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.45A 2p16A-2r0lA:
34.2		 2p16A-2r0lA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		5 / 8 ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
 0.51A 2vinA-2r0lA:
37.4		 2vinA-2r0lA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		8 / 12 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
 0.47A 2w26A-2r0lA:
34.3		 2w26A-2r0lA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.32A 3gy3A-2r0lA:
17.9		 3gy3A-2r0lA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		5 / 12 LYS A  16
GLY A 197
ILE A 212
ALA A  55
ASP A 194
 None
 1.04A 3nvkI-2r0lA:
undetectable		 3nvkI-2r0lA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 6 SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.21A 3rxfA-2r0lA:
18.0		 3rxfA-2r0lA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		5 / 11 SER A  54
GLY A 196
ALA A  55
PRO A  60
ILE A  35
 None
 1.00A 4dt8A-2r0lA:
undetectable		 4dt8A-2r0lA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 None
 0.50A 4fu8A-2r0lA:
37.0		 4fu8A-2r0lA:
38.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 189
ALA A 190
TRP A 215
GLY A 226
 None
 0.27A 4hfpD-2r0lA:
34.5		 4hfpD-2r0lA:
34.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 4 ILE A 213
SER A 214
ASP A 189
ASP A 186
 None
 1.41A 4krhB-2r0lA:
undetectable		 4krhB-2r0lA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		5 / 12 ALA A 183
LEU A 162
ALA A 139
ILE A 138
ILE A 121
 None
 0.96A 4r3aB-2r0lA:
undetectable		 4r3aB-2r0lA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		3 / 3 THR A 229
HIS A  48
LEU A 123
 None
 0.80A 5axdA-2r0lA:
undetectable		 5axdA-2r0lA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		3 / 3 THR A 229
HIS A  48
LEU A 123
 None
 0.79A 5axdC-2r0lA:
undetectable		 5axdC-2r0lA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 7 SER A 195
ASP A 217
ARG A 221
GLY A 221
 None
 0.94A 5btfA-2r0lA:
undetectable
5btfC-2r0lA:
undetectable
5btfD-2r0lA:
undetectable		 5btfA-2r0lA:
18.29
5btfC-2r0lA:
18.29
5btfD-2r0lA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 4 ILE A 106
LEU A  68
HIS A  48
ALA A 112
 None
 0.90A 6ck2C-2r0lA:
undetectable
6ck2D-2r0lA:
undetectable		 6ck2C-2r0lA:
7.23
6ck2D-2r0lA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 5 LEU A 123
THR A  49
ARG B 395
ARG B 390
 None
 1.07A 6ew0B-2r0lA:
undetectable		 6ew0B-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 5 LEU A 123
THR A  49
ARG B 395
ARG B 390
 None
 1.07A 6ew0D-2r0lA:
undetectable		 6ew0D-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 5 LEU A 105
LEU A 123
THR A  49
PRO B 388
 None
 1.02A 6ew0F-2r0lA:
undetectable		 6ew0F-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 6 LEU A 105
LEU A 123
THR A  49
PRO B 388
 None
 1.02A 6ew0G-2r0lA:
undetectable		 6ew0G-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 6 LEU A 123
THR A  49
ARG B 395
ARG B 390
 None
 1.08A 6ew0G-2r0lA:
undetectable		 6ew0G-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 5 LEU A 123
THR A  49
ARG B 395
ARG B 390
 None
 1.07A 6ew0H-2r0lA:
undetectable		 6ew0H-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens) 		4 / 5 LEU A 123
THR A  49
ARG B 395
ARG B 390
 None
 1.07A 6ew0I-2r0lA:
undetectable		 6ew0I-2r0lA:
13.33