SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 136
SER A 138
ILE A 228
SER A 144
 None
 1.28A 2xz5A-2r0sA:
undetectable
2xz5B-2r0sA:
undetectable		 2xz5A-2r0sA:
22.07
2xz5B-2r0sA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 289
LEU A  48
GLU A  47
GLN A 290
PHE A 153
 None
 1.40A 3apwB-2r0sA:
undetectable		 3apwB-2r0sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  43
ASN A 286
GLU A  47
 None
 0.87A 3kpdC-2r0sA:
undetectable		 3kpdC-2r0sA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 256
LEU A 179
VAL A 171
 None
 0.50A 4jecB-2r0sA:
undetectable		 4jecB-2r0sA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 225
ALA A 264
ASN A 268
ILE A 274
 None
 0.50A 4y03A-2r0sA:
15.5		 4y03A-2r0sA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 225
ALA A 264
ASN A 268
ILE A 274
 None
 0.36A 4y03B-2r0sA:
15.6		 4y03B-2r0sA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 310
LEU A 258
GLU A  47
ILE A 289
ILE A 250
 None
 1.19A 5ifuA-2r0sA:
undetectable		 5ifuA-2r0sA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 7 PRO A  84
PHE A  80
SER A 138
ASN A 134
 None
 1.11A 5l1fC-2r0sA:
2.8		 5l1fC-2r0sA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 212
TYR A 225
ASN A 268
ILE A 274
 None
 0.78A 5pbeA-2r0sA:
14.0		 5pbeA-2r0sA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 8 CYH A 130
TYR A 133
ASN A 134
ILE A 140
 None
 0.41A 5y1yA-2r0sA:
12.5		 5y1yA-2r0sA:
18.86