SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 232
GLU A 227
TYR A 225
 None
 0.77A 2zmbA-2r0vA:
undetectable		 2zmbA-2r0vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 232
GLU A 227
TYR A 226
 None
 0.77A 2zmbA-2r0vA:
undetectable		 2zmbA-2r0vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 212
LEU A 222
ASN A 268
ILE A 274
 None
 0.86A 3u5jA-2r0vA:
12.7		 3u5jA-2r0vA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 212
VAL A 217
ASN A 268
ILE A 274
 None
 0.65A 3u5kB-2r0vA:
12.8		 3u5kB-2r0vA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 212
VAL A 217
ASN A 268
ILE A 274
 None
 0.71A 3u5kC-2r0vA:
12.9		 3u5kC-2r0vA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 5 SER A  46
LYS A  45
LEU A  48
ASP A  51
 None
 1.25A 4ifxA-2r0vA:
undetectable		 4ifxA-2r0vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 5 SER A  46
LYS A  45
LEU A  48
ASP A  51
 None
 1.25A 4ig1A-2r0vA:
undetectable		 4ig1A-2r0vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 256
LEU A 179
VAL A 171
 None
 0.44A 4jecB-2r0vA:
undetectable		 4jecB-2r0vA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 217
LEU A 222
ASN A 268
ILE A 274
 None
 0.88A 4lzrA-2r0vA:
12.9		 4lzrA-2r0vA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 167
MET A 257
LYS A 174
ILE A 289
ILE A 250
 None
None
None
SO4  A 343 (-3.8A)
None
 0.97A 4p3qA-2r0vA:
undetectable		 4p3qA-2r0vA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 5 SER A  46
LYS A  45
LEU A  48
ASP A  51
 None
 1.25A 4xdtA-2r0vA:
undetectable		 4xdtA-2r0vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 225
ALA A 264
ASN A 268
ILE A 274
 None
 0.55A 4y03A-2r0vA:
15.9		 4y03A-2r0vA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 225
ALA A 264
ASN A 268
ILE A 274
 None
 0.40A 4y03B-2r0vA:
15.9		 4y03B-2r0vA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 7 PRO A  84
PHE A  80
SER A 138
ASN A 134
 ALY  A  25 ( 4.2A)
None
None
ALY  A  25 ( 3.3A)
 1.06A 5l1fC-2r0vA:
undetectable		 5l1fC-2r0vA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		5 / 6 PRO A 212
VAL A 217
TYR A 225
ASN A 268
ILE A 274
 None
 0.87A 5pbeA-2r0vA:
14.6		 5pbeA-2r0vA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3H_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		5 / 10 LYS A 157
ARG A 163
GLU A  47
ASN A 286
PHE A 153
 None
SO4  A 343 ( 4.8A)
SO4  A 343 (-3.3A)
SO4  A 343 (-3.7A)
None
 1.14A 5v3hA-2r0vA:
1.9		 5v3hA-2r0vA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4
(Saccharomyces
cerevisiae) 		4 / 8 CYH A 130
TYR A 133
ASN A 134
ILE A 140
 ALY  A  25 ( 3.9A)
ALY  A  25 ( 4.7A)
ALY  A  25 ( 3.3A)
ALY  A  25 ( 4.3A)
 0.42A 5y1yA-2r0vA:
12.9		 5y1yA-2r0vA:
14.86