SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 2r0x POSSIBLE FLAVIN
REDUCTASE
(Histophilus
somni) 		4 / 8 LEU A  72
SER A  97
GLN A  29
THR A  99
 None
 1.02A 1ig3A-2r0xA:
undetectable
1ig3B-2r0xA:
undetectable		 1ig3A-2r0xA:
23.21
1ig3B-2r0xA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2r0x POSSIBLE FLAVIN
REDUCTASE
(Histophilus
somni) 		4 / 7 SER A 105
ARG A  65
PHE A  61
PHE A  32
 None
EDO  A 167 (-4.1A)
None
None
 1.11A 2q6hA-2r0xA:
undetectable		 2q6hA-2r0xA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2r0x POSSIBLE FLAVIN
REDUCTASE
(Histophilus
somni) 		4 / 7 VAL A  37
ALA A  34
PHE A  32
TYR A  58
 None
 1.06A 4lb2A-2r0xA:
undetectable		 4lb2A-2r0xA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_E_FOLE201_0
(FOLATE ECF
TRANSPORTER)		 2r0x POSSIBLE FLAVIN
REDUCTASE
(Histophilus
somni) 		5 / 9 ALA A  55
TYR A  58
PHE A  61
ASN A  70
THR A  22
 SO4  A 164 (-3.5A)
None
None
None
None
 1.47A 4z7fE-2r0xA:
undetectable		 4z7fE-2r0xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2r0x POSSIBLE FLAVIN
REDUCTASE
(Histophilus
somni) 		4 / 5 LEU A 108
PHE A  83
LEU A  72
TRP A  98
 None
 1.35A 5m10A-2r0xA:
undetectable		 5m10A-2r0xA:
12.75