SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		5 / 12 LEU A 302
LEU A  15
LEU A  17
GLY A  18
PHE A 298
 None
 1.44A 1d4fA-2r14A:
undetectable		 1d4fA-2r14A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 8 ILE A 164
ARG A 154
LEU A 156
GLU A 160
 None
 0.72A 2cdqA-2r14A:
undetectable		 2cdqA-2r14A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		3 / 3 THR A  68
PRO A 123
PRO A 118
 None
 0.72A 2d55C-2r14A:
undetectable		 2d55C-2r14A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 6 PRO A 338
LEU A  11
ARG A 340
GLY A 344
 None
 0.99A 2hs2B-2r14A:
undetectable		 2hs2B-2r14A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 5 ARG A 169
ALA A 225
ASP A 224
GLU A 228
 None
 1.05A 2xrzA-2r14A:
undetectable		 2xrzA-2r14A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 5 TYR A 271
ILE A 303
LEU A  15
LEU A  22
 None
 1.00A 2zb7A-2r14A:
undetectable		 2zb7A-2r14A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		5 / 12 ALA A 257
ILE A 212
ALA A 188
ASP A 250
PHE A 242
 None
 1.21A 3axtA-2r14A:
undetectable		 3axtA-2r14A:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		5 / 9 THR A  32
ALA A  62
HIS A 186
PHE A 246
TYR A 356
 FMN  A 401 ( 3.8A)
FMN  A 401 (-3.2A)
FMN  A 401 ( 3.6A)
None
TXD  A 600 ( 3.4A)
 0.95A 3upwA-2r14A:
45.6		 3upwA-2r14A:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 5 ARG A 316
THR A 321
ASP A 319
GLU A 292
 None
 1.20A 3v5vC-2r14A:
0.0
3v5vD-2r14A:
0.3		 3v5vC-2r14A:
24.62
3v5vD-2r14A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 6 TYR A 356
ARG A  35
ASP A 351
TYR A 363
 TXD  A 600 ( 3.4A)
None
None
None
 1.21A 3wfaA-2r14A:
0.0
3wfaB-2r14A:
7.3		 3wfaA-2r14A:
19.78
3wfaB-2r14A:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		5 / 7 THR A  32
TRP A 106
HIS A 186
ASN A 189
TYR A 356
 FMN  A 401 ( 3.8A)
TXD  A 600 (-3.8A)
FMN  A 401 ( 3.6A)
TXD  A 600 ( 3.9A)
TXD  A 600 ( 3.4A)
 0.37A 4a3uA-2r14A:
53.8		 4a3uA-2r14A:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		5 / 7 THR A  32
TRP A 106
HIS A 186
ASN A 189
TYR A 356
 FMN  A 401 ( 3.8A)
TXD  A 600 (-3.8A)
FMN  A 401 ( 3.6A)
TXD  A 600 ( 3.9A)
TXD  A 600 ( 3.4A)
 0.31A 4a3uB-2r14A:
54.2		 4a3uB-2r14A:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		5 / 7 THR A  32
TRP A 106
HIS A 186
ASN A 189
LEU A 245
 FMN  A 401 ( 3.8A)
TXD  A 600 (-3.8A)
FMN  A 401 ( 3.6A)
TXD  A 600 ( 3.9A)
TXD  A 600 ( 4.8A)
 0.89A 4awuA-2r14A:
56.4		 4awuA-2r14A:
49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		6 / 12 LEU A 103
ALA A 102
LEU A  17
LEU A  57
GLY A 301
LEU A 269
 None
 1.32A 4dm8B-2r14A:
undetectable		 4dm8B-2r14A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 7 ALA A 313
PHE A 327
ALA A 324
LEU A  11
 None
 0.83A 4du2A-2r14A:
undetectable		 4du2A-2r14A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 7 ALA A 313
PHE A 327
ALA A 324
LEU A  11
 None
 0.88A 4du2B-2r14A:
undetectable		 4du2B-2r14A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 5 GLU A 292
ARG A 316
THR A 321
ASP A 319
 None
 1.25A 4e7cA-2r14A:
0.0
4e7cB-2r14A:
0.0		 4e7cA-2r14A:
24.62
4e7cB-2r14A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		3 / 3 ASP A 318
LEU A  11
GLY A  10
 None
 0.41A 4xmfA-2r14A:
undetectable		 4xmfA-2r14A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		3 / 3 THR A  80
ASP A  81
ALA A  82
 None
 0.10A 5g5gB-2r14A:
undetectable		 5g5gB-2r14A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		5 / 12 VAL A 222
ALA A 187
VAL A 185
LEU A 269
ILE A 212
 None
 1.22A 5hv1A-2r14A:
undetectable		 5hv1A-2r14A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 7 GLY A 300
GLY A  18
SER A  19
LEU A  22
 None
 0.72A 5izfA-2r14A:
undetectable		 5izfA-2r14A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		4 / 5 ARG A 174
TRP A  79
ALA A  82
PRO A  41
 None
 1.48A 5syiA-2r14A:
undetectable		 5syiA-2r14A:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		6 / 8 THR A  32
TRP A 106
HIS A 186
ASN A 189
PHE A 246
TYR A 356
 FMN  A 401 ( 3.8A)
TXD  A 600 (-3.8A)
FMN  A 401 ( 3.6A)
TXD  A 600 ( 3.9A)
None
TXD  A 600 ( 3.4A)
 1.07A 5v4vA-2r14A:
47.5		 5v4vA-2r14A:
40.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		6 / 8 THR A  32
TRP A 106
HIS A 186
ASN A 189
PHE A 246
TYR A 356
 FMN  A 401 ( 3.8A)
TXD  A 600 (-3.8A)
FMN  A 401 ( 3.6A)
TXD  A 600 ( 3.9A)
None
TXD  A 600 ( 3.4A)
 1.08A 5v4vB-2r14A:
47.6		 5v4vB-2r14A:
40.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 2r14 MORPHINONE REDUCTASE
(Pseudomonas
putida) 		3 / 3 GLU A 244
LEU A 248
ARG A 110
 None
 0.82A 6d8fA-2r14A:
2.2		 6d8fA-2r14A:
19.85