SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 2r15 MYOMESIN-1
(Homo
sapiens) 		5 / 10 LEU A1477
ALA A1554
GLY A1548
VAL A1544
ILE A1468
 None
 0.97A 1hsgA-2r15A:
undetectable		 1hsgA-2r15A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r15 MYOMESIN-1
(Homo
sapiens) 		5 / 12 ILE A1633
ILE A1584
VAL A1582
LEU A1578
PHE A1631
 None
 1.07A 1uduB-2r15A:
undetectable		 1uduB-2r15A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r15 MYOMESIN-1
(Homo
sapiens) 		4 / 7 GLY A1508
THR A1507
GLN A1476
PHE A1480
 None
 1.23A 2qx4A-2r15A:
undetectable
2qx4B-2r15A:
undetectable		 2qx4A-2r15A:
25.00
2qx4B-2r15A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 2r15 MYOMESIN-1
(Homo
sapiens) 		5 / 10 LEU A1477
ALA A1554
GLY A1548
VAL A1544
ILE A1468
 None
 0.99A 3em3B-2r15A:
undetectable		 3em3B-2r15A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2r15 MYOMESIN-1
(Homo
sapiens) 		4 / 5 TYR A1555
GLN A1559
ILE A1566
PHE A1558
 None
 1.17A 3ls4L-2r15A:
11.0		 3ls4L-2r15A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 2r15 MYOMESIN-1
(Homo
sapiens) 		5 / 10 LEU A1477
ALA A1554
GLY A1548
VAL A1544
ILE A1468
 None
 0.99A 3oxwD-2r15A:
undetectable		 3oxwD-2r15A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2r15 MYOMESIN-1
(Homo
sapiens) 		5 / 11 LEU A1477
ALA A1554
GLY A1548
VAL A1544
ILE A1468
 None
 1.01A 3oxxD-2r15A:
undetectable		 3oxxD-2r15A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2r15 MYOMESIN-1
(Homo
sapiens) 		4 / 6 ASN A1495
ARG A1500
TYR A1529
LEU A1546
 None
 1.47A 4f8yA-2r15A:
undetectable
4f8yB-2r15A:
undetectable		 4f8yA-2r15A:
19.30
4f8yB-2r15A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2r15 MYOMESIN-1
(Homo
sapiens) 		4 / 6 THR A1593
ALA A1629
THR A1628
VAL A1596
 None
 1.02A 5ecoA-2r15A:
undetectable		 5ecoA-2r15A:
16.32