SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ROX_B_T44B128_1 (TRANSTHYRETIN)	2r16	NEUREXIN-1-ALPHA (Bos taurus)	4 / 6	LEU A 785 GLU A 803 LEU A 776 THR A 765	None	0.96A	2roxB-2r16A: undetectable	2roxB-2r16A: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FAK_A_SAMA201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	2r16	NEUREXIN-1-ALPHA (Bos taurus)	5 / 10	LEU A 889 ILE A 887 GLY A 893 SER A 878 THR A 724	None	1.02A	4fakA-2r16A: undetectable	4fakA-2r16A: 19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_C_SUEC1203_1 (NS3 PROTEASE)	2r16	NEUREXIN-1-ALPHA (Bos taurus)	5 / 9	PHE A 753 VAL A 819 ILE A 854 ARG A 820 ASP A 748	None	1.45A	6c2mC-2r16A: undetectable	6c2mC-2r16A: 16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWD_A_GLYA715_0 (DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1)	2r16	NEUREXIN-1-ALPHA (Bos taurus)	4 / 6	GLY A 790 ASN A 788 ASP A 772 SER A 770	None None CA A1000 (-2.8A) None	1.08A	6dwdA-2r16A: undetectable 6dwdC-2r16A: undetectable	6dwdA-2r16A: 17.19 6dwdC-2r16A: 17.19

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ROX_B_T44B128_1","TRANSTHYRETIN","2r16","NEUREXIN-1-ALPHA","Bos taurus",4,"LEU A 785;GLU A 803;LEU A 776;THR A 765","None","0.96A","2roxB-2r16A:undetectable","2roxB-2r16A:21.02"],["4FAK_A_SAMA201_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H","2r16","NEUREXIN-1-ALPHA","Bos taurus",5,"LEU A 889;ILE A 887;GLY A 893;SER A 878;THR A 724","None","1.02A","4fakA-2r16A:undetectable","4fakA-2r16A:19.15"],["6C2M_C_SUEC1203_1","NS3 PROTEASE","2r16","NEUREXIN-1-ALPHA","Bos taurus",5,"PHE A 753;VAL A 819;ILE A 854;ARG A 820;ASP A 748","None","1.45A","6c2mC-2r16A:undetectable","6c2mC-2r16A:16.11"],["6DWD_A_GLYA715_0","DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1","2r16","NEUREXIN-1-ALPHA","Bos taurus",4,"GLY A 790;ASN A 788;ASP A 772;SER A 770","None;None; CA A1000 (-2.8A);None","1.08A","6dwdA-2r16A:undetectable;6dwdC-2r16A:undetectable","6dwdA-2r16A:17.19;6dwdC-2r16A:17.19"]]